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These include addressing modifiable risk factors for disease progression and instituting interventions such as weight loss, nutrition, physical activity, and potentially regenerative medicine strategies. This review will focus on these nonoperative treatment strategies with a focus on when treatments are necessary, who will benefit from these approaches, why they are specifically appropriate, and, finally, how these treatments directly modify the structure of a patient's cartilage and resulting symptoms.<\/jats:p>","DOI":"10.1055\/s-0040-1713813","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T22:51:50Z","timestamp":1594767110000},"page":"1078-1087","source":"Crossref","is-referenced-by-count":7,"title":["Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?"],"prefix":"10.1055","volume":"33","author":[{"given":"Chad","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Fausett","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, Illinois"},{"name":"Department of Physical Medicine and Rehabilitation, McGaw Medical Center of Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Jayabalan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, Illinois"},{"name":"Department of Physical Medicine and Rehabilitation, Northwestern Feinberg School of Medicine, Chicago, 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