{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:12:08Z","timestamp":1790208728580,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n            Objective\u2003The optimal noninvasive ventilation (NIV) modality in the treatment of transient tachypnea of the newborn (TTN) is still unknown. The aim of this study was to compare nasal continuous positive airway pressure (NCPAP) versus bi-level CPAP in the treatment of TTN.<\/jats:p><jats:p>\n            Study Design\u2003This was a prospective randomized study that was conducted in a tertiary level neonatal intensive care unit of Zekai Tahir Burak Women's Health Education and Research Hospital during the 1-year period between April 2017 and March 2018. The study included infants at \u226534 gestational weeks and birth weight \u22652,000\u2009g who were diagnosed with TTN. The patients were randomized to either NCPAP or bi-level CPAP groups as initial respiratory support. The primary outcome was the rate of NIV failure.<\/jats:p><jats:p>\n            Results\u2003A total of 151 infants were incorporated into the study. The intubation rate was significantly higher in the NCPAP group (15\/75) compared with the bi-level CPAP group (6\/76) (p\u2009=\u20090.032). There was a significant decrease in the level of pCO2 at the 12 (60.7\u2009\u00b1\u20096.7 vs. 66.3\u2009\u00b1\u20098.8, p\u2009=\u20090.017) and 24 (50\u2009\u00b1\u20098 vs. 53\u2009\u00b1\u200910, p\u2009=\u20090.028) hours of NIV in the bi-level CPAP group compared with the NCPAP group. Duration of NIV, total respiratory support, hospital stay, and the incidence of pneumothorax were similar between the groups.<\/jats:p><jats:p>\n            Conclusion\u2003Bi-level CPAP reduced the rate of NIV failure and pCO2 levels at the 12 and 24\u2009hours in late preterm and term infants with a diagnosis of TTN.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1713815","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T22:51:36Z","timestamp":1593730296000},"page":"1483-1487","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Nasal CPAP versus Bi-level CPAP in Transient Tachypnea of the Newborn: A Randomized Trial"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-1369","authenticated-orcid":false,"given":"Buse","family":"\u00d6zer Bekmez","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim Alyama\u00e7","family":"Dizdar","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-4671","authenticated-orcid":false,"given":"Mehmet","family":"B\u00fcy\u00fcktiryaki","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatmanur","family":"Sari","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"Ura\u015f","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-3003","authenticated-orcid":false,"given":"Fuat Emre","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eerife Suna","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, The University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"issue":"S 03","key":"ref1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/14767058.2010.507971","article-title":"Transient tachypnea of the newborn: what is new?","volume":"23","author":"M 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