{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:27:19Z","timestamp":1783002439250,"version":"3.54.5"},"reference-count":58,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review provides recommendations for the treatment of neurogenic orthostatic hypotension (nOH), postprandial hypotension, and supine hypertension. It focuses on novel treatment strategies and new insights into the mechanism underlying these conditions. Our goal is to provide practical advice for clinicians on how to screen, diagnose, and treat these conditions with nonpharmacological and pharmacological approaches. For each disorder, we offered a stepwise recommendation on how to apply these new concepts to successfully ameliorate the symptoms associated with OH to prevent syncope and falls. The management of OH in patients who also have supine hypertension requires special considerations and pharmacotherapy. It is noteworthy that there are few therapeutic options for OH and only two Food and Drug Administration\u2013approved drugs for the treatment of OH and nOH based on randomized clinical trials. We will use these studies to develop evidence-based guidelines for OH. The research is limited for postprandial hypotension and supine hypertension, and therefore the recommendations will be based on small studies, clinical expertise, and, above all, an understanding of the underlying pathophysiology.<\/jats:p>","DOI":"10.1055\/s-0040-1713886","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:27:54Z","timestamp":1602739674000},"page":"515-522","source":"Crossref","is-referenced-by-count":26,"title":["Management of Orthostatic Hypotension, Postprandial Hypotension, and Supine Hypertension"],"prefix":"10.1055","volume":"40","author":[{"given":"Cyndya A.","family":"Shibao","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Biaggioni","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00415-016-8375-x","article-title":"The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension","volume":"264","author":"C H Gibbons","year":"2017","journal-title":"J Neurol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10286-004-0188-9","article-title":"Segmental orthostatic fluid shifts","volume":"14","author":"A Diedrich","year":"2004","journal-title":"Clin Auton Res"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ana.25170","article-title":"Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies","volume":"83","author":"L Norcliffe-Kaufmann","year":"2018","journal-title":"Ann Neurol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1161\/01.STR.29.1.104","article-title":"Autoregulation of cerebral blood flow in orthostatic hypotension","volume":"29","author":"V Novak","year":"1998","journal-title":"Stroke"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/mds.26079","article-title":"Orthostatic hypotension in Parkinson disease: how much you fall or how low you go?","volume":"30","author":"J A Palma","year":"2015","journal-title":"Mov Disord"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/01.HYP.19.6.508","article-title":"Orthostatic hypotension in older adults. 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