{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:21:24Z","timestamp":1793060484355,"version":"4.5.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"14","funder":[{"name":"Boston University Reproductive, Perinatal and Pediatric Epidemiology Training Program","award":["NIH T32 HD052458"],"award-info":[{"award-number":["NIH T32 HD052458"]}]},{"DOI":"10.13039\/100013861","name":"Charles Koch Foundation","doi-asserted-by":"crossref","award":["NIH T32 HD052458"],"award-info":[{"award-number":["NIH T32 HD052458"]}],"id":[{"id":"10.13039\/100013861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n            Objective\u2003The incidence of placenta accreta spectrum (PAS) has been increasing in the United States. In addition, there has also been an increase in the utilization of in vitro fertilization (IVF). The IVF pregnancies confer an increased risk of adverse obstetric and neonatal outcomes, but there is limited data on whether IVF is associated with PAS. The aim of this study is to assess the association between IVF and the risk of PAS.<\/jats:p><jats:p>\n            Study Design\u2003This was a retrospective cohort study of deliveries from January 1, 2013 to August 1, 2018 at a tertiary hospital in the Massachusetts. IVF pregnancies were compared with non-IVF pregnancies, and PAS diagnosis was confirmed by histopathology reports. Hospital administrative data and medical record review were used, and supplemented with data from birth certificates from the Massachusetts Department of Public Health.<\/jats:p><jats:p>\n            Results\u2003We identified 28,344 pregnancies that met inclusion criteria, of which 1,418 (5.0%) were IVF pregnancies. The overall incidence of PAS was 0.4% (2.2% in the IVF group and 0.3% in the non-IVF group). Women who underwent IVF had 5.5 times the risk of PAS (95% confidence interval [CI]: 3.4\u20138.7) compared with women in the non-IVF group, adjusted for maternal age, nulliparity, and year of delivery (Table 5). Compared with women in the non-IVF group, the IVF group had fewer prior cesarean deliveries (22.6 vs. 64.2%) and a lower prevalence of placenta previa (19.4 vs. 44.4%).<\/jats:p><jats:p>\n            Conclusion\u2003Women with an IVF pregnancy carry an increased risk of PAS compared with non-IVF. Among women who underwent IVF, there was a lower prevalence of prior cesarean deliveries and placenta previa. Future work is needed to identify the mechanism of association for this increased risk as well as a reliable tool for antenatal detection in this cohort of women.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1713887","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T22:39:37Z","timestamp":1593988777000},"page":"1533-1539","source":"Crossref","is-referenced-by-count":36,"title":["Placenta Accreta Spectrum: In Vitro Fertilization and Non-In Vitro Fertilization and Placenta Accreta Spectrum in a Massachusetts Cohort"],"prefix":"10.1055","volume":"38","author":[{"given":"Anna M.","family":"Modest","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"},{"name":"Boston IVF Inc, Waltham, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-6772","authenticated-orcid":false,"given":"Scott A.","family":"Shainker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.ajog.2004.12.074","article-title":"Abnormal placentation: twenty-year analysis","volume":"192","author":"S Wu","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"384.e1","DOI":"10.1016\/j.ajog.2015.05.002","article-title":"Morbidity associated with cesarean delivery in the United States: is placenta accreta an increasingly important contributor?","volume":"213","author":"A A Creanga","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/01.AOG.0000219750.79480.84","article-title":"Maternal morbidity associated with multiple repeat cesarean deliveries","volume":"107","author":"R M Silver","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"e52893","DOI":"10.1371\/journal.pone.0052893","article-title":"Incidence and risk factors for placenta accreta\/increta\/percreta in the UK: a national case-control study","volume":"7","author":"K E Fitzpatrick","year":"2012","journal-title":"PLoS ONE"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0002-9378(97)70463-0","article-title":"Clinical risk factors for placenta previa-placenta accreta","volume":"177","author":"D A Miller","year":"1997","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/AOG.0000000000002983","article-title":"Obstetric care consensus no. 7: placenta accreta spectrum","volume":"132","author":"American College of Obstetricians and Gynecologists and Society for the Maternal-Fetal Medicine","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/uog.20244","article-title":"Impact of placenta previa with placenta accreta spectrum disorder on fetal growth","volume":"54","author":"E Jauniaux","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00404-019-05338-y","article-title":"Hemorrhagic morbidity in placenta accreta spectrum with and without placenta previa","volume":"300","author":"B M Mulla","year":"2019","journal-title":"Arch Gynecol Obstet"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ajog.2020.01.034","article-title":"Characteristics and outcomes of placenta accreta spectrum in twins versus singletons: a study from the Pan American Society for Placenta Accreta Spectrum (PAS2)","volume":"222","author":"A A Shamshirsaz","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1055\/s-0038-1676488","article-title":"Prevalence of sonographic markers of placenta accreta spectrum in low-risk pregnancies","volume":"36","author":"J Philips","year":"2019","journal-title":"Am J Perinatol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12958-016-0225-2","article-title":"Systematic review of worldwide trends in assisted reproductive technology 2004-2013","volume":"15","author":"V A Kushnir","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.fertnstert.2015.01.021","article-title":"Cryopreserved embryo transfer is an independent risk factor for placenta accreta","volume":"103","author":"D J Kaser","year":"2015","journal-title":"Fertil Steril"},{"issue":"09","key":"ref13","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1471-0528.2011.02976.x","article-title":"Placenta accreta is associated with IVF pregnancies: a retrospective chart review","volume":"118","author":"E Esh-Broder","year":"2011","journal-title":"BJOG"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s10815-019-01545-3","article-title":"Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study","volume":"36","author":"A M Modest","year":"2019","journal-title":"J Assist Reprod Genet"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00404-015-4006-5","article-title":"Hysterectomy for placenta accreta; methods for gross and microscopic pathology examination","volume":"293","author":"K Dannheim","year":"2016","journal-title":"Arch Gynecol Obstet"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ajog.2017.05.067","article-title":"Placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging","volume":"218","author":"E Jauniaux","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"07","key":"ref17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.placenta.2008.04.008","article-title":"Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast","volume":"29","author":"P Tantbirojn","year":"2008","journal-title":"Placenta"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"38.e1","DOI":"10.1016\/j.ajog.2011.01.040","article-title":"Predictors of massive blood loss in women with placenta accreta","volume":"205","author":"J D Wright","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/14767058.2017.1289163","article-title":"Placenta previa and maternal hemorrhagic morbidity","volume":"31","author":"K J Gibbins","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1701-2163(16)32112-0","article-title":"Pregnancy outcomes after assisted reproductive technology","volume":"28","author":"V M Allen","year":"2006","journal-title":"J Obstet Gynaecol Can"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fertnstert.2012.08.060","article-title":"Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study","volume":"99","author":"A N Imudia","year":"2013","journal-title":"Fertil Steril"},{"issue":"06","key":"ref22","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.fertnstert.2012.03.028","article-title":"Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization","volume":"97","author":"A N Imudia","year":"2012","journal-title":"Fertil Steril"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.fertnstert.2011.02.044","article-title":"In vitro fertilization and adverse childhood outcomes: what we know, where we are going, and how we will get there. A glimpse into what lies behind and beckons ahead","volume":"95","author":"S K Kalra","year":"2011","journal-title":"Fertil Steril"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.rbmo.2013.03.018","article-title":"Ovarian stimulation leads to a severe implantation defect in mice","volume":"27","author":"S Deng","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.placenta.2005.04.005","article-title":"Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen during early baboon pregnancy","volume":"27","author":"E D Albrecht","year":"2006","journal-title":"Placenta"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1210\/en.2008-0116","article-title":"Suppression of extravillous trophoblast vascular endothelial growth factor expression and uterine spiral artery invasion by estrogen during early baboon pregnancy","volume":"149","author":"T W Bonagura","year":"2008","journal-title":"Endocrinology"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"337.e1","DOI":"10.1016\/j.ajog.2019.05.035","article-title":"Maternal outcomes in unexpected placenta accreta spectrum disorders: single-center experience with a multidisciplinary team","volume":"221","author":"H Erfani","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/AOG.0000000000002442","article-title":"Outcomes of planned compared with urgent deliveries using a multidisciplinary team approach for morbidly adherent placenta","volume":"131","author":"A A Shamshirsaz","year":"2018","journal-title":"Obstet Gynecol"},{"key":"ref29","first-page":"480","article-title":"Birth outcomes by infertility diagnosis analyses of the Massachusetts outcomes study of assisted reproductive technologies (MOSART)","volume":"60","author":"B Luke","year":"2015","journal-title":"J Reprod Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1713887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:52:51Z","timestamp":1637625171000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1713887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,5]]},"references-count":29,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,11,22]]},"published-print":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1713887","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,5]]}}}