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This review summarizes our current understanding of how the autonomic nervous system emerges from the organized spatial and temporal patterning of precursor cell migration, proliferation, communication, and differentiation, and discusses potential clinical implications for developmental disorders of the autonomic nervous system, including familial dysautonomia, Hirschsprung disease, Rett syndrome, and congenital central hypoventilation syndrome.<\/jats:p>","DOI":"10.1055\/s-0040-1713926","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T22:50:44Z","timestamp":1600123844000},"page":"473-484","source":"Crossref","is-referenced-by-count":10,"title":["Development of the Autonomic Nervous System: Clinical Implications"],"prefix":"10.1055","volume":"40","author":[{"given":"Frances","family":"Lefcort","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Montana State University, Bozeman, 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01","key":"ref4","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1016\/j.ydbio.2018.05.013","article-title":"Neurocristopathies: new insights 150 years after the neural crest discovery","volume":"444","author":"G A Vega-Lopez","year":"2018","journal-title":"Dev Biol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0012-1606(92)90231-5","article-title":"Descriptive and experimental analysis of the dispersion of neural crest cells along the dorsolateral path and their entry into ectoderm in the chick embryo","volume":"151","author":"C A Erickson","year":"1992","journal-title":"Dev Biol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4161\/cam.1.4.5447","article-title":"Neural crest cell fate: to be or not to be prespecified","volume":"1","author":"F Lefcort","year":"2007","journal-title":"Cell Adhes Migr"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/dev.108.4.605","article-title":"Pathways of trunk neural crest cell migration in the mouse embryo as revealed by vital dye labelling","volume":"108","author":"G N Serbedzija","year":"1990","journal-title":"Development"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1387\/ijdb.160408gv","article-title":"Trunk neural crest cells: formation, migration and beyond","volume":"61","author":"G A Vega-Lopez","year":"2017","journal-title":"Int J Dev Biol"},{"issue":"S 01","key":"ref9","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.ydbio.2018.03.024","article-title":"The issue of the multipotency of the neural crest cells","volume":"444","author":"E Dupin","year":"2018","journal-title":"Dev Biol"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1242\/dev.083725","article-title":"Evidence for dynamic rearrangements but lack of fate or position restrictions in premigratory avian trunk neural crest","volume":"140","author":"M C McKinney","year":"2013","journal-title":"Development"},{"issue":"39","key":"ref11","doi-asserted-by":"crossref","first-page":"13078","DOI":"10.1523\/JNEUROSCI.0892-10.2010","article-title":"CXCR4 controls ventral migration of sympathetic precursor cells","volume":"30","author":"J C Kasemeier-Kulesa","year":"2010","journal-title":"J Neurosci"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nn1962","article-title":"Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells","volume":"10","author":"L George","year":"2007","journal-title":"Nat Neurosci"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/cne.22248","article-title":"Patterned assembly and neurogenesis in the chick dorsal root ganglion","volume":"518","author":"L George","year":"2010","journal-title":"J Comp Neurol"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1242\/dev.093294","article-title":"A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells","volume":"140","author":"E Nitzan","year":"2013","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/bs.ctdb.2015.12.003","article-title":"The neural crest migrating into the twenty-first century","volume":"116","author":"M E Bronner","year":"2016","journal-title":"Curr Top Dev Biol"},{"issue":"S 01","key":"ref16","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.ydbio.2018.02.008","article-title":"Schwann cell precursor: a neural crest cell in disguise?","volume":"444","author":"A Furlan","year":"2018","journal-title":"Dev 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Parasympathetic neurons originate from nerve-associated peripheral glial progenitors","volume":"345","author":"V Dyachuk","year":"2014","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.1253286","article-title":"Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors","volume":"345","author":"I Espinosa-Medina","year":"2014","journal-title":"Science"},{"issue":"45","key":"ref21","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1073\/pnas.1710308114","article-title":"Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest","volume":"114","author":"I Espinosa-Medina","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.aal3753","article-title":"Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla","volume":"357","author":"A Furlan","year":"2017","journal-title":"Science"},{"issue":"09","key":"ref23","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.semcdb.2010.08.008","article-title":"Nrg1\/ErbB signaling networks in Schwann cell development and myelination","volume":"21","author":"J Newbern","year":"2010","journal-title":"Semin Cell Dev Biol"},{"issue":"22","key":"ref24","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1242\/dev.01429","article-title":"Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells","volume":"131","author":"N M Joseph","year":"2004","journal-title":"Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature13536","article-title":"Glial origin of mesenchymal stem cells in a tooth model system","volume":"513","author":"N Kaukua","year":"2014","journal-title":"Nature"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2009.07.049","article-title":"Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin","volume":"139","author":"I Adameyko","year":"2009","journal-title":"Cell"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/dvdy.21498","article-title":"A Histone2BCerulean BAC transgene identifies differential expression of Phox2b in migrating enteric neural crest derivatives and enteric glia","volume":"237","author":"J C Corpening","year":"2008","journal-title":"Dev Dyn"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.200301041","article-title":"Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells","volume":"162","author":"M E De Bellard","year":"2003","journal-title":"J Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2017.01.006","article-title":"Enteric nervous system development: a crest cell's journey from neural tube to colon","volume":"66","author":"N Nagy","year":"2017","journal-title":"Semin Cell Dev 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Burstyn-Cohen","year":"2004","journal-title":"Development"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1242\/dev.01857","article-title":"Essential role of non-canonical Wnt signalling in neural crest migration","volume":"132","author":"J De Calisto","year":"2005","journal-title":"Development"},{"issue":"08","key":"ref34","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1242\/dev.128.8.1467","article-title":"The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos","volume":"128","author":"R Kos","year":"2001","journal-title":"Development"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1101\/gad.186601","article-title":"The transcription factor Sox10 is a key regulator of peripheral glial development","volume":"15","author":"S Britsch","year":"2001","journal-title":"Genes 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Dev"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1460-9568.2011.07860.x","article-title":"Transcriptional control of differentiation and neurogenesis in autonomic ganglia","volume":"34","author":"H Rohrer","year":"2011","journal-title":"Eur J Neurosci"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00441-017-2693-x","article-title":"From proliferation to target innervation: signaling molecules that direct sympathetic nervous system development","volume":"372","author":"W H Chan","year":"2018","journal-title":"Cell Tissue Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.1222369","article-title":"The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification","volume":"336","author":"D Saito","year":"2012","journal-title":"Science"},{"issue":"03","key":"ref42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81112-5","article-title":"Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members","volume":"85","author":"N M Shah","year":"1996","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/20700","article-title":"The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives","volume":"399","author":"A Pattyn","year":"1999","journal-title":"Nature"},{"issue":"20","key":"ref44","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1242\/dev.129.20.4729","article-title":"Development of chromaffin cells depends on MASH1 function","volume":"129","author":"K Huber","year":"2002","journal-title":"Development"},{"issue":"26","key":"ref45","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1242\/dev.00866","article-title":"Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways","volume":"130","author":"S Dauger","year":"2003","journal-title":"Development"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ydbio.2005.01.007","article-title":"The role of Phox2B in chromaffin cell development","volume":"279","author":"K Huber","year":"2005","journal-title":"Dev Biol"},{"issue":"14","key":"ref47","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1242\/dev.127.14.3045","article-title":"Establishing neuronal identity in vertebrate neurogenic placodes","volume":"127","author":"C VH Baker","year":"2000","journal-title":"Development"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ydbio.2016.03.015","article-title":"A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons","volume":"415","author":"B A Karpinski","year":"2016","journal-title":"Dev Biol"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ydbio.2014.12.012","article-title":"Cranial placodes: models for exploring the multi-facets of cell adhesion in epithelial rearrangement, collective migration and neuronal movements","volume":"401","author":"M A Breau","year":"2015","journal-title":"Dev Biol"},{"issue":"S 01","key":"ref50","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2982.2008.01104.x","article-title":"Vagal and hormonal gut-brain communication: from satiation to satisfaction","volume":"20","author":"H R Berthoud","year":"2008","journal-title":"Neurogastroenterol Motil"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","article-title":"Transneuronal propagation of pathologic \u03b1-synuclein from the gut to the brain models Parkinson's disease","volume":"103","author":"S Kim","year":"2019","journal-title":"Neuron"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/368147a0","article-title":"Mice lacking brain-derived neurotrophic factor develop with sensory deficits","volume":"368","author":"P Ernfors","year":"1994","journal-title":"Nature"},{"issue":"17","key":"ref53","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1523\/JNEUROSCI.16-17-05361.1996","article-title":"Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing","volume":"16","author":"J T Erickson","year":"1996","journal-title":"J Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/375238a0","article-title":"Sensory but not motor neuron deficits in mice lacking NT4 and BDNF","volume":"375","author":"X Liu","year":"1995","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/375235a0","article-title":"Neuronal deficits, not involving motor neurons, in mice lacking BDNF and\/or NT4","volume":"375","author":"J C Conover","year":"1995","journal-title":"Nature"},{"issue":"06","key":"ref56","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0092-8674(94)90377-8","article-title":"Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development","volume":"76","author":"K R Jones","year":"1994","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/382076a0","article-title":"Renal and neuronal abnormalities in mice lacking GDNF","volume":"382","author":"M W Moore","year":"1996","journal-title":"Nature"},{"issue":"06","key":"ref58","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1523\/JNEUROSCI.19-06-02131.1999","article-title":"BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons","volume":"19","author":"R Brady","year":"1999","journal-title":"J Neurosci"},{"issue":"20","key":"ref59","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1523\/JNEUROSCI.23-20-07685.2003","article-title":"Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-B\u00f6tzinger complex of neonatal mice","volume":"23","author":"M Thoby-Brisson","year":"2003","journal-title":"J Neurosci"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/dvdy.23898","article-title":"Slit\/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut","volume":"242","author":"D Goldberg","year":"2013","journal-title":"Dev Dyn"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1365-2982.2011.01764.x","article-title":"Development of the vagal innervation of the gut: steering the wandering nerve","volume":"23","author":"E M Ratcliffe","year":"2011","journal-title":"Neurogastroenterol Motil"},{"issue":"08","key":"ref62","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"J Kupari","year":"2019","journal-title":"Cell Reports"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molmet.2018.03.016","article-title":"Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms","volume":"12","author":"K L Egerod","year":"2018","journal-title":"Mol Metab"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.03.022","article-title":"Vagal sensory neuron subtypes that differentially control breathing","volume":"161","author":"R B Chang","year":"2015","journal-title":"Cell"},{"issue":"20","key":"ref65","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1242\/dev.128.20.3963","article-title":"RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons","volume":"128","author":"H Enomoto","year":"2001","journal-title":"Development"},{"issue":"15","key":"ref66","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1073\/pnas.0811521106","article-title":"Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification","volume":"106","author":"Q Schwarz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"ref67","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1242\/dev.02662","article-title":"Eph\/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia","volume":"133","author":"J C Kasemeier-Kulesa","year":"2006","journal-title":"Development"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1523\/JNEUROSCI.07-11-03739.1987","article-title":"Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation","volume":"7","author":"H Rohrer","year":"1987","journal-title":"J Neurosci"},{"issue":"02","key":"ref69","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0012-1606(78)90030-1","article-title":"The relationship of cell division to the acquisition of adrenergic characteristics by developing sympathetic ganglion cell precursors","volume":"65","author":"T P Rothman","year":"1978","journal-title":"Dev Biol"},{"issue":"03","key":"ref70","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/(SICI)1097-4695(19990905)40:3<366::AID-NEU8>3.0.CO;2-B","article-title":"Mitotic sympathetic neuroblasts initiate axonal pathfinding in vivo","volume":"40","author":"E Wolf","year":"1999","journal-title":"J Neurobiol"},{"issue":"01","key":"ref71","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ydbio.2006.03.008","article-title":"Delays in neuronal differentiation in Mash1\/Ascl1 mutants","volume":"295","author":"A Pattyn","year":"2006","journal-title":"Dev Biol"},{"issue":"27","key":"ref72","doi-asserted-by":"crossref","first-page":"13414","DOI":"10.1073\/pnas.1903510116","article-title":"HIF-1\u03b1 is required for development of the sympathetic nervous system","volume":"116","author":"R Bohuslavova","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.46.3.384","article-title":"Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein","volume":"46","author":"R Levi-Montalcini","year":"1960","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"E J Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"issue":"07","key":"ref75","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1523\/JNEUROSCI.13-07-02739.1993","article-title":"The neurotrophic factor concept: a reexamination","volume":"13","author":"S Korsching","year":"1993","journal-title":"J Neurosci"},{"issue":"06","key":"ref76","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0092-8674(94)90378-6","article-title":"Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons","volume":"76","author":"C Crowley","year":"1994","journal-title":"Cell"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/368246a0","article-title":"Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk\/NGF receptor gene","volume":"368","author":"R J Smeyne","year":"1994","journal-title":"Nature"},{"issue":"03","key":"ref78","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.4523-03.2004","article-title":"Heterogeneous requirement of NGF for sympathetic target innervation in vivo","volume":"24","author":"N O Glebova","year":"2004","journal-title":"J Neurosci"},{"issue":"03","key":"ref79","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1523\/JNEUROSCI.17-03-01168.1997","article-title":"Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies","volume":"17","author":"A C Granholm","year":"1997","journal-title":"J Neurosci"},{"issue":"01","key":"ref80","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/dev.122.1.349","article-title":"Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts","volume":"122","author":"P L Durbec","year":"1996","journal-title":"Development"},{"issue":"04","key":"ref81","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0896-6273(01)80031-3","article-title":"GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion","volume":"23","author":"J Nishino","year":"1999","journal-title":"Neuron"},{"issue":"23","key":"ref82","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1523\/JNEUROSCI.1445-09.2009","article-title":"Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons","volume":"29","author":"D Bodmer","year":"2009","journal-title":"J Neurosci"},{"issue":"07","key":"ref83","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1523\/JNEUROSCI.4243-10.2011","article-title":"Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development","volume":"31","author":"A Armstrong","year":"2011","journal-title":"J Neurosci"},{"issue":"01","key":"ref84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2012.09.006","article-title":"Signal processing at mammalian carotid body chemoreceptors","volume":"24","author":"C A Nurse","year":"2013","journal-title":"Semin Cell Dev Biol"},{"issue":"16","key":"ref85","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1113\/jphysiol.2013.269829","article-title":"Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors","volume":"592","author":"C A Nurse","year":"2014","journal-title":"J Physiol"},{"issue":"01","key":"ref86","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00424-015-1734-0","article-title":"Carotid body oxygen sensing and adaptation to hypoxia","volume":"468","author":"J L\u00f3pez-Barneo","year":"2016","journal-title":"Pflugers Arch"},{"issue":"04","key":"ref87","first-page":"583","article-title":"[Experimental research on the embryologic origin of the carotid body in birds]","volume":"275","author":"N Le Douarin","year":"1972","journal-title":"C R Acad Hebd Seances Acad Sci D"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.autneu.2007.06.036","article-title":"Sympathetic ganglion origin of the carotid body glomus cells revealed by Mash1 and Frs2\u03b12F\/2F null mutant mice","volume":"135","author":"Y Kameda","year":"2007","journal-title":"Auton Neurosci"},{"issue":"02","key":"ref89","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"R Pardal","year":"2007","journal-title":"Cell"},{"issue":"03","key":"ref90","doi-asserted-by":"crossref","first-page":"e44598","DOI":"10.15252\/embr.201744598","article-title":"Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia","volume":"19","author":"V Sobrino","year":"2018","journal-title":"EMBO Rep"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"e34681","DOI":"10.7554\/eLife.34681","article-title":"HIF-2\u03b1 is essential for carotid body development and function","volume":"7","author":"D Macias","year":"2018","journal-title":"eLife"},{"issue":"01","key":"ref92","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2005.04.004","article-title":"Mash1 is required for glomus cell formation in the mouse carotid body","volume":"283","author":"Y Kameda","year":"2005","journal-title":"Dev Biol"},{"issue":"S 01","key":"ref93","doi-asserted-by":"crossref","first-page":"S308","DOI":"10.1016\/j.ydbio.2018.05.016","article-title":"Striking parallels between carotid body glomus cell and adrenal chromaffin cell development","volume":"444","author":"D Hockman","year":"2018","journal-title":"Dev Biol"},{"issue":"21","key":"ref94","doi-asserted-by":"crossref","first-page":"dev162552","DOI":"10.1242\/dev.162552","article-title":"Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla","volume":"145","author":"R Lumb","year":"2018","journal-title":"Development"},{"issue":"01","key":"ref95","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autneu.2009.07.020","article-title":"The development of the chromaffin cell lineage from the neural crest","volume":"151","author":"K Huber","year":"2009","journal-title":"Auton Neurosci"},{"issue":"01","key":"ref96","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1038\/s41598-019-40501-0","article-title":"RNA-seq of isolated chromaffin cells highlights the role of sex-linked and imprinted genes in adrenal medulla development","volume":"9","author":"W H Chan","year":"2019","journal-title":"Sci Rep"},{"issue":"03","key":"ref97","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-006-0213-5","article-title":"Development of adrenal chromaffin cells in Sf1 heterozygous mice","volume":"325","author":"J Lohr","year":"2006","journal-title":"Cell Tissue Res"},{"issue":"06","key":"ref98","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/stem.2002","article-title":"Multipotent glia-like stem cells mediate stress adaptation","volume":"33","author":"M F Rubin de Celis","year":"2015","journal-title":"Stem Cells"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1755-8794-5-48","article-title":"Integrative analysis of neuroblastoma and pheochromocytoma genomics data","volume":"5","author":"P M Szab\u00f3","year":"2012","journal-title":"BMC Med Genomics"},{"key":"ref100","volume-title":"The Enteric Nervous System","author":"J B Furness","year":"2006"},{"key":"ref101","volume-title":"The Second Brain","author":"M D Gershon","year":"1998"},{"issue":"04","key":"ref102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/cge.12054","article-title":"Building a brain in the gut: development of the enteric nervous system","volume":"83","author":"A M Goldstein","year":"2013","journal-title":"Clin Genet"},{"issue":"05","key":"ref103","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"J B Furness","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"S 04","key":"ref104","first-page":"iv33","article-title":"Sympathetic input into the enteric nervous system","volume":"47","author":"O Lundgren","year":"2000","journal-title":"Gut"},{"issue":"03","key":"ref105","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1053\/j.gastro.2011.06.002","article-title":"Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo","volume":"141","author":"X Wang","year":"2011","journal-title":"Gastroenterology"},{"issue":"01","key":"ref106","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/dbio.2000.9886","article-title":"Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model","volume":"227","author":"R P Kapur","year":"2000","journal-title":"Dev Biol"},{"issue":"41","key":"ref107","doi-asserted-by":"crossref","first-page":"16372","DOI":"10.1523\/JNEUROSCI.2079-13.2013","article-title":"GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors","volume":"33","author":"T Uesaka","year":"2013","journal-title":"J Neurosci"},{"issue":"01","key":"ref108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2000.9876","article-title":"Postmigratory enteric and sympathetic neural precursors share common, developmentally regulated, responses to BMP2","volume":"227","author":"J M Pisano","year":"2000","journal-title":"Dev Biol"},{"issue":"17","key":"ref109","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1523\/JNEUROSCI.3688-03.2004","article-title":"Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset","volume":"24","author":"A Chalazonitis","year":"2004","journal-title":"J Neurosci"},{"issue":"06","key":"ref110","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.mod.2005.03.003","article-title":"BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system","volume":"122","author":"A M Goldstein","year":"2005","journal-title":"Mech Dev"},{"issue":"01","key":"ref111","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ydbio.2006.07.016","article-title":"BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition","volume":"299","author":"M Fu","year":"2006","journal-title":"Dev Biol"},{"issue":"01","key":"ref112","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/dvdy.20943","article-title":"Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4","volume":"236","author":"C Faure","year":"2007","journal-title":"Dev Dyn"},{"issue":"05","key":"ref113","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/cne.21770","article-title":"Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit","volume":"509","author":"A Chalazonitis","year":"2008","journal-title":"J Comp Neurol"},{"issue":"15","key":"ref114","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1523\/JNEUROSCI.0202-16.2016","article-title":"Ascl1 is required for the development of specific neuronal subtypes in the enteric nervous system","volume":"36","author":"F Memic","year":"2016","journal-title":"J Neurosci"},{"issue":"02","key":"ref115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0012-1606(88)90217-5","article-title":"Accumulation of components of basal laminae: association with the failure of neural crest cells to colonize the presumptive aganglionic bowel of ls\/ls mutant mice","volume":"125","author":"R F Payette","year":"1988","journal-title":"Dev Biol"},{"issue":"04","key":"ref116","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000147776","article-title":"Extracellular matrix and adhesive molecules in the early development of the gut and its innervation in normal and spotting lethal rat embryos","volume":"154","author":"D F Newgreen","year":"1995","journal-title":"Acta Anat (Basel)"},{"issue":"08","key":"ref117","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0022-3468(92)90545-I","article-title":"Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschsprung's disease","volume":"27","author":"D H Parikh","year":"1992","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref118","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ydbio.2007.10.028","article-title":"The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells","volume":"313","author":"J-M Delalande","year":"2008","journal-title":"Dev Biol"},{"issue":"01","key":"ref119","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/dev.122.1.349","article-title":"Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts","volume":"122","author":"P L Durbec","year":"1996","journal-title":"Development"},{"issue":"05","key":"ref120","doi-asserted-by":"crossref","first-page":"e64077","DOI":"10.1371\/journal.pone.0064077","article-title":"Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut","volume":"8","author":"J E Simkin","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"ref121","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.00463","article-title":"The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system","volume":"130","author":"K Niederreither","year":"2003","journal-title":"Development"},{"issue":"12","key":"ref122","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1242\/dev.126.12.2785","article-title":"Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system","volume":"126","author":"S Taraviras","year":"1999","journal-title":"Development"},{"issue":"06","key":"ref123","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/dvdy.22630","article-title":"Gdnf is mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon","volume":"240","author":"O Mwizerwa","year":"2011","journal-title":"Dev Dyn"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"A Schuchardt","year":"1994","journal-title":"Nature"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/382073a0","article-title":"Defects in enteric innervation and kidney development in mice lacking GDNF","volume":"382","author":"J G Pichel","year":"1996","journal-title":"Nature"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/382070a0","article-title":"Renal agenesis and the absence of enteric neurons in mice lacking GDNF","volume":"382","author":"M P S\u00e1nchez","year":"1996","journal-title":"Nature"},{"issue":"02","key":"ref127","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80541-3","article-title":"GFR \u03b11-deficient mice have deficits in the enteric nervous system and kidneys","volume":"21","author":"H Enomoto","year":"1998","journal-title":"Neuron"},{"issue":"15","key":"ref128","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1523\/JNEUROSCI.6244-09.2010","article-title":"Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice","volume":"30","author":"T Uesaka","year":"2010","journal-title":"J Neurosci"},{"issue":"05","key":"ref129","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1172\/JCI34425","article-title":"Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice","volume":"118","author":"T Uesaka","year":"2008","journal-title":"J Clin Invest"},{"issue":"05","key":"ref130","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/dneu.20869","article-title":"Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut","volume":"71","author":"E M Ratcliffe","year":"2011","journal-title":"Dev Neurobiol"},{"issue":"05","key":"ref131","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/cne.21027","article-title":"Netrin\/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut","volume":"498","author":"E M Ratcliffe","year":"2006","journal-title":"J Comp Neurol"},{"issue":"05","key":"ref132","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0896-6273(03)00730-X","article-title":"Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET","volume":"40","author":"A Barlow","year":"2003","journal-title":"Neuron"},{"issue":"07","key":"ref133","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0092-8674(94)90018-3","article-title":"Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons","volume":"79","author":"A G Baynash","year":"1994","journal-title":"Cell"},{"issue":"07","key":"ref134","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(94)90017-5","article-title":"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice","volume":"79","author":"K Hosoda","year":"1994","journal-title":"Cell"},{"issue":"02","key":"ref135","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0012-1606(98)80010-9","article-title":"Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3","volume":"198","author":"A Chalazonitis","year":"1998","journal-title":"Dev Biol"},{"issue":"31","key":"ref136","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1145-09.2009","article-title":"5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice","volume":"29","author":"M-T Liu","year":"2009","journal-title":"J Neurosci"},{"issue":"09","key":"ref137","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1172\/JCI58186","article-title":"Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut","volume":"121","author":"N M Joseph","year":"2011","journal-title":"J Clin Invest"},{"issue":"09","key":"ref138","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1172\/JCI58200","article-title":"Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury","volume":"121","author":"C Laranjeira","year":"2011","journal-title":"J Clin Invest"},{"issue":"18","key":"ref139","doi-asserted-by":"crossref","first-page":"E3709","DOI":"10.1073\/pnas.1619406114","article-title":"Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis","volume":"114","author":"S Kulkarni","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"ref140","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1056\/NEJMoa1706594","article-title":"Molecular genetic anatomy and risk profile of Hirschsprung's disease","volume":"380","author":"J M Tilghman","year":"2019","journal-title":"N Engl J Med"},{"issue":"08","key":"ref141","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1073\/pnas.0809630105","article-title":"Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease","volume":"106","author":"M M Garcia-Barcelo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"06","key":"ref142","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00439-010-0813-8","article-title":"Fine mapping of the 9q31 Hirschsprung's disease locus","volume":"127","author":"C S Tang","year":"2010","journal-title":"Hum Genet"},{"issue":"07","key":"ref143","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3748\/wjg.v21.i7.2040","article-title":"Depletion of the IKBKAP ortholog in zebrafish leads to Hirschsprung disease-like phenotype","volume":"21","author":"W W-C Cheng","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pneurobio.2016.06.003","article-title":"Familial dysautonomia: History, genotype, phenotype and translational research","volume":"152","author":"L Norcliffe-Kaufmann","year":"2017","journal-title":"Prog Neurobiol"},{"issue":"18","key":"ref145","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1517\/14656566.2014.970530","article-title":"Current treatments in familial dysautonomia","volume":"15","author":"J-A Palma","year":"2014","journal-title":"Expert Opin 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Genet"},{"issue":"03","key":"ref149","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/humu.22010","article-title":"Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells","volume":"33","author":"N Boone","year":"2012","journal-title":"Hum Mutat"},{"issue":"01","key":"ref150","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41467-018-03221-z","article-title":"Elongator and codon bias regulate protein levels in mammalian peripheral neurons","volume":"9","author":"J Goffena","year":"2018","journal-title":"Nat Commun"},{"issue":"07","key":"ref151","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cell.2015.05.022","article-title":"Optimization of codon translation rates via tRNA modifications maintains proteome integrity","volume":"161","author":"D D Nedialkova","year":"2015","journal-title":"Cell"},{"issue":"46","key":"ref152","doi-asserted-by":"crossref","first-page":"18698","DOI":"10.1073\/pnas.1308596110","article-title":"Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons","volume":"110","author":"L George","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref153","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1242\/dev.107797","article-title":"A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation","volume":"141","author":"M Z Jackson","year":"2014","journal-title":"Development"},{"issue":"23","key":"ref154","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1093\/hmg\/dds354","article-title":"IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia","volume":"21","author":"P Dietrich","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"06","key":"ref155","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/hmg\/ddv634","article-title":"Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia","volume":"25","author":"E Morini","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"11","key":"ref156","doi-asserted-by":"crossref","first-page":"e113428","DOI":"10.1371\/journal.pone.0113428","article-title":"Involvement of IKAP in peripheral target innervation and in specific JNK and NGF signaling in developing PNS neurons","volume":"9","author":"A Abashidze","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"ref157","doi-asserted-by":"crossref","first-page":"e1006486","DOI":"10.1371\/journal.pgen.1006486","article-title":"Phosphatidylserine ameliorates neurodegenerative symptoms and enhances axonal transport in a mouse model of familial dysautonomia","volume":"12","author":"S Naftelberg","year":"2016","journal-title":"PLoS 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