{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:26Z","timestamp":1740126806955,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Objective\u2003This study aimed to examine maternal outcomes of ongoing pregnancies complicated by fetal life-limiting conditions.<\/jats:p><jats:p>Study design\u2003This was a retrospective matched cohort study of women with a diagnosis of fetal life-limiting condition between 2010 and 2018 in a single academic center. Cases were matched to controls (women who had normal fetal anatomic survey) according to year of delivery, body mass index, and parity in a 1:4 ratio. Bivariable and multivariable analyses were performed to compare the prevalence of the primary composite outcome, which included any one of the following: preeclampsia, gestational diabetes, cesarean delivery, third and fourth degree laceration, postpartum hemorrhage, blood transfusion, endometritis or wound infection, maternal intensive care unit admission, hysterectomy and maternal death, between cases and controls.<\/jats:p><jats:p>Results\u2003During the study period, we found 101 cases that met inclusion criteria, matched to 404 controls. The rate of the composite maternal outcome did not differ between the two groups (39.6 vs. 38.9%, p\u2009=\u20090.948). For individual outcomes, women with diagnosis of fetal life-limiting condition had higher rates of blood transfusion (2.0 vs. 0%, p\u2009=\u20090.005) and longer length of the first stage of labor (median of 12 [6.8\u201322.0] hours vs. 6.6 [3.9\u201311.0] hours; p\u2009&lt;\u20090.001). In a multivariable analysis, first stage of labor continued to be longer by an average of 6.48\u2009hours among women with a diagnosis of fetal life-limiting condition compared with controls.<\/jats:p><jats:p>Conclusion\u2003After controlling for confounding factors, except a longer first stage of labor, women diagnosed with fetal life-limiting conditions who continued the pregnancy did not have a higher rate of adverse maternal outcomes.<\/jats:p><jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0040-1713927","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T22:35:42Z","timestamp":1594334142000},"page":"099-104","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Outcomes of Ongoing Pregnancies Complicated by Fetal Life-Limiting Conditions"],"prefix":"10.1055","volume":"38","author":[{"given":"Talia","family":"Coney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Leuthner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-0201","authenticated-orcid":false,"given":"Anna","family":"Palatnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin"},{"name":"Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.siny.2014.08.007","article-title":"Ethical language and decision-making for prenatally diagnosed lethal malformations","volume":"19","author":"D Wilkinson","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.siny.2012.09.004","article-title":"Antenatal diagnosis and management of life-limiting conditions","volume":"18","author":"A C Breeze","year":"2013","journal-title":"Semin Fetal Neonatal Med"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/ANC.0000000000000704","article-title":"Perinatal counseling following a diagnosis of trisomy 13 or 18: incorporating the facts, parental values, and maintaining choices","volume":"20","author":"S R Leuthner","year":"2020","journal-title":"Adv Neonatal Care"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.pcl.2007.06.006","article-title":"Palliative care for the family carrying a fetus with a life-limiting diagnosis","volume":"54","author":"D Munson","year":"2007","journal-title":"Pediatr Clin North Am"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"d1808","DOI":"10.1136\/bmj.d1808","article-title":"Multidisciplinary palliative care in unborn and newborn babies","volume":"342","author":"M D Kilby","year":"2011","journal-title":"BMJ"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/OGX.0000000000000304","article-title":"Management considerations for ongoing pregnancies complicated by trisomy 13 and 18","volume":"71","author":"S K Dotters-Katz","year":"2016","journal-title":"Obstet Gynecol Surv"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/jpm.2018.0596","article-title":"Birth planning in uncertain or life-limiting fetal diagnoses: perspectives of physicians and parents","volume":"22","author":"D E Cortezzo","year":"2019","journal-title":"J Palliat Med"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"546.e1","DOI":"10.1016\/j.ajog.2011.02.027","article-title":"Placental expression of angiogenic factors in trisomy 13","volume":"204","author":"M Silasi","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1471-2393-13-209","article-title":"The natural history of pregnancies with a diagnosis of trisomy 18 or trisomy 13; 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