{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:22:23Z","timestamp":1776288143936,"version":"3.50.1"},"reference-count":19,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic plasma exchange (TPE) is a treatment administered with the aim of removing a pathogenic material or compound causing morbidity in a variety of neurologic, hematologic, renal, and autoimmune diseases. In this study, we aimed to assess the indications, efficacy, reliability, complications, and treatment response of pediatric patients for TPE. This retrospective study analyzed data from 39 patients aged from 0 to 18 years who underwent a total of 172 TPE sessions from January 2015 to April 2018 in a tertiary pediatric intensive care unit. Indications for TPE were, in order of frequency, macrophage activation syndrome (28.2%, n\u2009=\u200911), renal transplantation rejection (15.4%, n\u2009=\u20096), liver failure (15.4%, n\u2009=\u20096), Guillain\u2013Barre's syndrome (15%, n\u2009=\u20096), hemolytic uremic syndrome (7.7%, n\u2009=\u20093), acute demyelinating disease (7.7%, n\u2009=\u20093), septic shock (5.1%, n\u2009=\u20092), and intoxication (5.1%, n\u2009=\u20092). No patient had any adverse event related to the TPE during the procedure. The TPE session was ended prematurely in one patient due to insufficient vascular access and lack of blood flow (2.6%). In the long term, thrombosis due to the indwelling central catheter occurred (5.1%, n\u2009=\u20092). TPE appears to be an effective first-stage or supplementary treatment in a variety of diseases, may be safely used in pediatric patients, and there are significant findings that its area of use will increase. In experienced hands and when assessed carefully, it appears that the rate of adverse reactions and vascular access problems may be low enough to be negligible.<\/jats:p>","DOI":"10.1055\/s-0040-1714098","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T19:15:46Z","timestamp":1595272546000},"page":"106-109","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Plasma Exchange Application in Children Requires Individual Decision"],"prefix":"10.53391","volume":"10","author":[{"given":"G\u00fcrkan","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet","family":"Demirkol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Faculty of Medicine, Istanbul University, Istanbul, Turkey"},{"name":"Child Health Institute, Istanbul University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jca.2920080402","article-title":"An overview of current management","volume":"8","author":"R G Strauss","year":"1993","journal-title":"J Clin Apher"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0955-3886(99)00064-8","article-title":"Therapeutic plasma exchange and cytapheresis in pediatric patients","volume":"21","author":"J B Gorlin","year":"1999","journal-title":"Transfus Sci"},{"key":"ref3","first-page":"471","volume-title":"Pediatric therapeutic apheresis","author":"A F Elder","year":"2002"},{"key":"ref4","first-page":"343","volume-title":"Therapeutic apheresis","author":"B C McLeod","year":"2004"},{"key":"ref5","first-page":"353","volume-title":"Therapeutic cytapheresis","author":"A F Eder","year":"2004"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1212\/WNL.0b013e318207b1f6","article-title":"Evidence-based guideline update: plasmapheresis in neurologic disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology","volume":"76","author":"I Cortese","year":"2011","journal-title":"Neurology"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jca.21470","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society for Apheresis: the seventh special issue","volume":"31","author":"J Schwartz","year":"2016","journal-title":"J Clin Apher"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2340\/16501977-0235","article-title":"Reliability and validity of the Medical Research Council (MRC) scale and a modified scale for testing muscle strength in patients with radial palsy","volume":"40","author":"T Paternostro-Sluga","year":"2008","journal-title":"J Rehabil Med"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/0973-6247.165834","article-title":"Therapeutic plasma exchange in pediatric patients of Guillain-Barre syndrome: experience from a tertiary care centre","volume":"10","author":"M Gajjar","year":"2016","journal-title":"Asian J Transfus Sci"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc11256","article-title":"Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis\/sepsis\/multiple organ dysfunction syndrome\/macrophage activation syndrome: what is the treatment?","volume":"16","author":"D Demirkol","year":"2012","journal-title":"Crit Care"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0140-6736(96)09095-2","article-title":"Randomised Trial of Plasma exchange, intravenous immunoglobulin and combined treatments in GuillainBarre Syndrome. 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