{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:12:40Z","timestamp":1781115160103,"version":"3.54.1"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"S 02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to describe the epidemiology of vertically transmitted sepsis (VS) and nosocomial sepsis (NOS) in very low birth weight (VLBW) neonates (birth weight\u2009\u2264\u20091,500\u2009g) over the past 22 years in Spain.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective analysis of prospectively collected VS and NOS in neonates from 1996 to 2018 in the 44 neonatal units integrated in the Spanish Neonatal Network Grupo Castrillo.<\/jats:p><jats:p>\n            Results\u2003A total of 2,676 episodes of VS were recorded in 2,196,129 live births (LBs; 1.2\/1,000 LBs) over the study period (1996\u20132018). The incidence declined from 2.4 to 1 to 1.2\/1,000 LBs (p\u2009&lt;\u20090.0001). Of the 2,676 episodes, 95.7% were early onset (\u226472\u2009hours) and 4.3% cases late onset VS. Group B streptococcus (GBS) (33.1%) and E. coli (29.3%) were the most frequently isolated pathogen. The GBS incidence declined significantly from 1.25 to 0.21\/1,000 LBs (p\u2009&lt;\u20090.0001). E. coli incidence showed a significant increase trend in VLBW infants (p\u2009&lt;\u20090.05). The global mortality per 1000 LBs decreased from 0.21 to 0.13\/1,000. A total of 7,036 episodes of NOS involving 5,493 VLBW infants were registered over 20,935 neonatal admissions (NAs) in the study period (2006\u20132018). The incidence was 26.2 per 100 NAs. The median postnatal age at onset was 13 days (interquartile range [IQR]: 9\u201323 days). Around 80% of cases occurred in infants with a central line in place. Gram positive (GP) bacteria accounted for 66.2% with Staphylococcus epidermidis as the most frequently isolated pathogen, gram negative (GN) bacteria entailed 27.4%, and fungi 6.2%. Klebsiella sp. was the most common GN isolated and Candida albicans the most prevalent fungus. The overall mortality was 8.3%.<\/jats:p><jats:p>\n            Conclusion\u2003The causative pathogen of neonatal sepsis may change over time and between countries, therefore a national surveillance network based on a consensus definition could be essential to provide accurate information.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1714256","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T18:34:07Z","timestamp":1599590047000},"page":"S71-S75","source":"Crossref","is-referenced-by-count":21,"special_numbering":"S","title":["The Spanish National Network \u201cGrupo Castrillo\u201d: 22 Years of Nationwide Neonatal Infection Surveillance"],"prefix":"10.1055","volume":"37","author":[{"given":"Belen","family":"Fernandez Colomer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Central University Hospital of Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cernada Badia","sequence":"additional","affiliation":[{"name":"Neonatal Research Unit, Division of Neonatology, La Fe University Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Coto Cotallo","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Central University Hospital of Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Lopez Sastre","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Central University Hospital of Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Grupo Castrillo Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"issue":"04","key":"ref1","first-page":"309","article-title":"Neonatal sepsis of vertical transmission: an epidemiological study from the \u201cGrupo de Hospitales Castrillo\u201d","volume":"28","author":"J B L\u00f3pez Sastre","year":"2000","journal-title":"J Perinat Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1515\/JPM.2002.019","article-title":"Neonatal sepsis of nosocomial origin: an epidemiological study from the \u201cGrupo de Hospitales Castrillo\u201d","volume":"30","author":"J B L\u00f3pez Sastre","year":"2002","journal-title":"J Perinat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2431-7-9","article-title":"Evaluation of procalcitonin for diagnosis of neonatal sepsis of vertical 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Perinatol"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-0032-1333131","article-title":"Prevention of nosocomial infections in neonatal intensive care units","volume":"30","author":"P Manzoni","year":"2013","journal-title":"Am J Perinatol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1714256.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T18:36:48Z","timestamp":1599590208000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1714256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":13,"journal-issue":{"issue":"S 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