{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:58:55Z","timestamp":1772247535776,"version":"3.50.1"},"reference-count":32,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ICMR (Indian council of Medical Research), UGC-fellowship"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstarct<\/jats:title>\n<jats:p>\n<jats:bold>Background<\/jats:bold>\u2003Amyotrophic lateral sclerosis (ALS) is a rare motor neuron disease with progressive degeneration of motor neurons. Various molecules have been explored to provide the early diagnostic\/prognostic tool for ALS without getting much success in the field and miscellaneous reports studied in various population.<\/jats:p>\n<jats:p>\n<jats:bold>Objective<\/jats:bold>\u2003The study was aimed to see the differential expression of proteins involved in angiogenesis (angiogenin [ANG], vascular endothelial growth factor [VEGF], vascular endothelial growth factor receptor 2 [VEGFR2], etc), proteinopathy (transactive response DNA binding protein-43 [TDP-43] and optineurin [OPTN]), and neuroinflammation (monocyte chemoattractant protein-1[MCP-1]) based on the characteristics of ALS pathology. Though, suitable panel based on protein expression profile can be designed to robust the ALS identification by enhancing the prognostic and diagnostic efficacy for ALS.<\/jats:p>\n<jats:p>\n<jats:bold>Methods<\/jats:bold>\u2003A total of 89 ALS patients and 98 nonneurological controls were analyzed for the protein expression. Expression of angiogenic (VEGF, VEGFR2, and ANG), neuroinflammation (MCP-1), and proteinopathy (TDP-43 and OPTN) markers were estimated in plasma of the participants. Proteins were normalized with respective value of total protein before employing statistical analysis.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Analysis has exhibited significantly reduced expression of angiogenic, proteinopathy, and neuroinflammation biomarkers in ALS patients in comparison to controls. Spearman\u2019s correlation analysis has showed the positive correlation to each protein.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Altered expression of these proteins is indicating the prominent function in ALS pathology which may be interdependent and may have a synergistic role. Hence, a panel of expression can be proposed to diagnose ALS patient which may also suggest the modulation of therapeutic strategy according to expression profile of patient.<\/jats:p>","DOI":"10.1055\/s-0040-1714314","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:40:26Z","timestamp":1597970426000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of Plasma Biomarkers for Angiogenesis and Proteinopathy in Indian Amyotrophic Lateral Sclerosis Patients"],"prefix":"10.25259","volume":"11","author":[{"given":"Shweta","family":"Modgil","sequence":"first","affiliation":[{"name":"Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Khosla","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abha","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscience Research Lab, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"issue":"1","key":"10.1055\/s-0040-1714314\/ref-1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boill\u00e9e","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"10.1055\/s-0040-1714314\/ref-2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1055\/s-0040-1714314\/ref-3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/jnnp.2006.104828","article-title":"EURALS. 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