{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:22:45Z","timestamp":1761294165288,"version":"3.37.3"},"reference-count":166,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB1123 A2"],"award-info":[{"award-number":["SFB1123 A2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB1123 B2"],"award-info":[{"award-number":["SFB1123 B2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of atherosclerotic vascular disease is driven by a multitude of risk factors intertwining metabolic and inflammatory pathways. Increasing knowledge about platelet biology sheds light on how platelets take part in these processes from early to later stages of plaque development. Recent insights from experimental studies and mouse models substantiate platelets as initiators and amplifiers in atherogenic leukocyte recruitment. These studies are complemented by results from genetics studies shedding light on novel molecular mechanisms which provide an interesting prospect as novel targets. For instance, experimental studies provide further details how platelet-decorated von Willebrand factor tethered to activated endothelial cells plays a role in atherogenic monocyte recruitment. Novel aspects of platelets as atherogenic inductors of neutrophil extracellular traps and particularities in signaling pathways such as cyclic guanosine monophosphate and the inhibitory adaptor molecule SHB23\/LNK associating platelets with atherogenesis are shared. In summary, it was our intention to balance insights from recent experimental data that support a plausible role for platelets in atherogenesis against a paucity of clinical evidence needed to validate this concept in humans.<\/jats:p>","DOI":"10.1055\/s-0040-1714352","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T22:34:31Z","timestamp":1597012471000},"page":"1492-1504","source":"Crossref","is-referenced-by-count":7,"title":["Novel Approaches to Fine-Tune Therapeutic Targeting of Platelets in Atherosclerosis: A Critical Appraisal"],"prefix":"10.1055","volume":"120","author":[{"given":"Thorsten","family":"Kessler","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Klinik f\u00fcr Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK) e.V., Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Klinik f\u00fcr Herz- und Kreislauferkrankungen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK) e.V., Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-9370","authenticated-orcid":false,"given":"Philipp","family":"von Hundelshausen","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK) e.V., Partner Site Munich Heart Alliance, Munich, Germany"},{"name":"Institut f\u00fcr Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t, Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,9]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra1112570","article-title":"A tale of coronary artery disease and myocardial infarction","volume":"366","author":"E G Nabel","year":"2012","journal-title":"N Engl J Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MOL.0000000000000330","article-title":"The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity","volume":"27","author":"J Bor\u00e9n","year":"2016","journal-title":"Curr Opin Lipidol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic 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