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The aim of this article is to compare the clinical aspects, genetics, fluid biomarkers, imaging, treatment, and pathology of CTE to those of AD and bvFTD. A detailed clinical evaluation, neurocognitive assessment, and structural brain imaging can inform the differential diagnosis, while molecular biomarkers can help exclude underlying AD pathology. Prospective studies that include clinicopathological correlations are needed to establish tools that can more accurately determine the cause of neuropsychiatric decline in patients at risk for CTE.<\/jats:p>","DOI":"10.1055\/s-0040-1715134","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:37:42Z","timestamp":1597970262000},"page":"394-410","source":"Crossref","is-referenced-by-count":11,"title":["Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia"],"prefix":"10.1055","volume":"40","author":[{"given":"Orit H.","family":"Lesman-Segev","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California San Francisco, San Francisco, California"},{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California"},{"name":"Weill Neuroscience Institute, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.2017.8334","article-title":"Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football","volume":"318","author":"J 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