{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:05Z","timestamp":1790007305675,"version":"4.0.1"},"reference-count":12,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"10","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Primary dysmenorrhea occurs due to abnormal levels of prostanoids, uterine contractions, and uterine blood flow. However, the reasons for pain in primary dysmenorrhea have not yet been clarified. We examined the blood flow alterations in patients with primary dysmenorrhea and determined the relationship between ischemia-modified albumin (IMA) levels, as an ischemia indicator, and primary dysmenorrhea.<\/jats:p><jats:p>\n          Methods\u2003In the present study, 37 patients who had primary dysmenorrhea and were in their luteal and menstrual phase of their menstrual cycles were included. Thirty individuals who had similar demographic characteristics, who were between 18 and 30 years old and did not have gynecologic disease were included as control individuals. Their uterine artery Doppler indices and serum IMA levels were measured.<\/jats:p><jats:p>\n          Results\u2003Menstrual phase plasma IMA levels were significantly higher than luteal phase IMA levels, both in the patient and in the control groups (p\u2009&lt;\u20090.001). Although the menstrual phase IMA levels of patients were significantly higher than those of controls, luteal phase IMA levels were not significantly different between the two groups. Menstrual uterine artery pulsatility index (PI) and resistance index (RI) of primary dysmenorrhea patients were significantly different when compared with luteal uterine artery PI and RI levels. There was a positive correlation between menstrual phase IMA and uterine artery PI and RI in the primary dysmenorrhea.<\/jats:p><jats:p>\n          Conclusion\u2003Ischemia plays an important role in the etiology of the pain, which is frequently observed in patients with primary dysmenorrhea. Ischemia-modified albumin levels are considered as an efficient marker to determine the severity of pain and to indicate ischemia in primary dysmenorrhea.<\/jats:p>","DOI":"10.1055\/s-0040-1715141","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T23:31:15Z","timestamp":1604187075000},"page":"630-633","source":"Crossref","is-referenced-by-count":5,"title":["The Relationship between Serum Ischemia-Modified Albumin Levels and Uterine Artery Doppler Parameters in Patients with Primary Dysmenorrhea"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-9691","authenticated-orcid":false,"given":"Ertugrul","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Yahyal\u0131 State Hospital, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0930-775X","authenticated-orcid":false,"given":"Ozhan","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-6603","authenticated-orcid":false,"given":"Seyda","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-0945","authenticated-orcid":false,"given":"Cemal Resat","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, Ministry of Health Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jpag.2014.05.001","article-title":"The role of hypoxia at primary dysmenorrhea, utilizing a novel hypoxia marker--SCUBE1","volume":"28","author":"Y B Tekin","year":"2015","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ejogrb.2015.03.005","article-title":"Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study","volume":"188","author":"J C Patel","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod 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