{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:42:12Z","timestamp":1771674132378,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003This research was aimed to study the safety and efficacy of higher order multifetal pregnancy reduction (MFPR).<\/jats:p><jats:p>Study Design\u2003This was a retrospective study of patients from an academic maternity center between 2005 and 2015. We evaluated outcomes of 131 consecutive patients who underwent higher order MFPR (quadruplets and greater). MFPR was performed at 11 to 18 weeks of gestation in all cases. In total, 122 of 131 cases of higher order multiple pregnancy were reduced to twins. We discuss the perinatal outcomes of patients who underwent higher order MFPR, followed by a comparative analysis between the 122 cases of MFPR that were reduced to twins and 101 cases of nonreduced twin pregnancies.<\/jats:p><jats:p>Results\u2003The study included 104 sets of quadruplets, 20 sets of quintuplets, 5 sets of sextuplets, 1 set of septuplets, and 1 set of octuplets. The perinatal outcomes of the 131 cases were as follows: pregnancy loss, preterm deliveries at 28 to 33 (+6\/7) weeks, and preterm deliveries at 34 to 36 (+6\/7) weeks occurred in 23.66, 9, and 37% of cases, respectively. The mean time of delivery was 36.56\u2009\u00b1\u20091.77 weeks, and mean birth weight was 2,409.90\u2009\u00b1\u2009458.16\u2009g, respectively. A total of 122 cases that were reduced to twins were compared with nonreduced twins. The pregnancy loss rate for reduced twins was significantly higher than that for nonreduced twins. The preterm labor rate, mean delivery week, mean birth weight, birth-weight discordance, incidence of gestational diabetes mellitus, and pregnancy-induced hypertension were not significantly different between the groups (p\u2009&gt;\u20090.05).<\/jats:p><jats:p>Conclusion\u2003Perinatal outcomes were significantly improved by reducing the number of fetuses in higher order multifetal pregnancies. This study involved a large, diverse sample population, and the results can be used as a reference while conducting prenatal counseling.<\/jats:p>","DOI":"10.1055\/s-0040-1715167","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T23:24:46Z","timestamp":1598570686000},"page":"e228-e233","source":"Crossref","is-referenced-by-count":5,"title":["Safety and Efficacy of Higher Order Multifetal Pregnancy Reduction: A Single-Center Retrospective Study"],"prefix":"10.1055","volume":"10","author":[{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"},{"name":"Department of Obstetrics and Gynecology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Yan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Tun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.47102\/10.47102\/annals-acadmedsg.V33N2p195","article-title":"Twin births in Singapore: a population-based study using the National Birth Registry","volume":"33","author":"K S Chia","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"ref2","first-page":"1","article-title":"Births: final data for 2009. 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