{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:44:43Z","timestamp":1750239883586,"version":"3.37.3"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sj\u00f6gren's syndrome is a systemic autoimmune disease that classically presents with xerophthalmia and xerostomia. However, neurological manifestations occur in 10 to 60% of patients with Sj\u00f6gren's syndrome and can often precede classic sicca symptoms in Sj\u00f6gren's syndrome in some cases up to several years. Rarely, cranial neuropathy can be the initial presentation. Here, we present the first case of a 15-year-old girl with left abducens palsy in the setting of a new diagnosis of Sj\u00f6gren's syndrome. Comprehensive evaluation revealed elevated Sj\u00f6gren's syndrome\u2013related antigen A-60 antibody. Cerebrospinal fluid analysis was unremarkable. Radiological studies demonstrated evidence of chronic parotitis. Acute treatment included high-dose methylprednisolone and rituximab, and symptoms resolved by follow-up at 2 weeks. The most common neurological disorder of Sj\u00f6gren's syndrome is pure sensory neuropathy. In pediatric Sj\u00f6gren's syndrome, neurological complications are rare but include aseptic meningoencephalitis, acute disseminated encephalomyelitis, transverse myelitis, optic neuritis, and cranial neuropathies. In the circumstance of a cranial neuropathy, the trigeminal nerve is most commonly involved but oculomotor nerves can occasionally be affected. Abducens palsies have been described in four patients with Sj\u00f6gren's syndrome, typically women and all middle aged or older, with our patient being the first pediatric case. Thus, it is important to consider screening for Sj\u00f6gren's syndrome in the evaluation of pediatric patients with new onset of isolated cranial neuropathy even in the absence of classic sicca symptoms.<\/jats:p>","DOI":"10.1055\/s-0040-1715627","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T23:57:52Z","timestamp":1607990272000},"page":"394-397","source":"Crossref","is-referenced-by-count":2,"title":["A Presentation of Pediatric Sj\u00f6gren's Syndrome with Abducens Nerve Palsy"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-6501","authenticated-orcid":false,"given":"Jenny","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, United States"},{"name":"Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, Georgia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Gadde","sequence":"additional","affiliation":[{"name":"Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, United States"},{"name":"Department of Radiology, Ann & Robert Lurie Children\u2019s Hospital of Chicago, Northwestern University, Chicago, Illinois, Unites States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, United States"},{"name":"Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, Georgia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Gombolay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, United States"},{"name":"Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, Georgia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/14397595.2018.1438093","article-title":"Clinical practice guideline for Sj\u00f6gren's syndrome 2017","volume":"28","author":"T Sumida","year":"2018","journal-title":"Mod Rheumatol"},{"issue":"01","key":"ref2","first-page":"29","article-title":"Neurological involvement in primary Sj\u00f6gren syndrome","volume":"38","author":"F Teixeira","year":"2013","journal-title":"Acta Reumatol Port"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.braindev.2015.05.005","article-title":"Childhood Sj\u00f6gren syndrome presenting as acute brainstem encephalitis","volume":"38","author":"Y 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cranial nerve enhancement on MRI in primary Sj\u00f6gren's syndrome","volume":"49","author":"K Sakai","year":"2010","journal-title":"Intern Med"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jdsr.2019.09.006","article-title":"B cell dysregulation in primary Sj\u00f6gren's syndrome: A review","volume":"55","author":"H M Ibrahem","year":"2019","journal-title":"Jpn Dent Sci Rev"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.rdc.2017.06.002","article-title":"Neurologic Manifestations of Primary Sj\u00f6gren Syndrome","volume":"43","author":"M Margaretten","year":"2017","journal-title":"Rheum Dis Clin North 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