{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:10:42Z","timestamp":1780434642310,"version":"3.54.1"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2003Hyperkinetic seizures are described as seizure onset in the frontal or temporal lobe. Additional localizing information is important for diagnostic workup and surgical therapy. We describe diagnostic workup and surgical outcomes in three patients with pharmacoresistant focal emotional seizures with hyperkinetic elements.<\/jats:p><jats:p>\n          Methods\/Results\u2003High-resolution 3\u2009Tesla (T) magnetic resonance imaging (MRI) did not reveal clear-cut lesions. Invasive video-electroencephalography (EEG) with depth electrodes along the cingulate sulcus (bilateral; patients 1 and 3), right; patient 2 provided congruent results for a circumscribed seizure onset zone within the medial frontal lobe (right: patients 1 and 2; left: patient 3). Topectomies were performed in all patients. Histopathology revealed a small focal cortical dysplasia in the three cases (focal cortical dysplasia [FCD] IIA: patient 1; FCD IIB: patients 2 and 3). All patients remained completely seizure-free since surgery (Engel 1A; follow-up: 9\u201328 months).<\/jats:p><jats:p>\n          Conclusion\u2003Ictal fear associated with hyperkinetic semiology points to a seizure-onset zone within the anteromedial frontal lobe (anterior cingulate gyrus). Ictal semiology is crucial for the placement of depth electrodes, especially in MRI-negative cases. These cases illustrate a clinical advantage to the new International League against Epilepsy (ILAE) seizure classification, emphasizing initial clinical symptoms.<\/jats:p>","DOI":"10.1055\/s-0040-1715630","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T22:37:46Z","timestamp":1598395066000},"page":"044-047","source":"Crossref","is-referenced-by-count":7,"title":["Hyperkinetic Seizures with Ictal Fear as Localizing Ictal Signs in MRI-Negative Medial Frontal Lobe Epilepsy"],"prefix":"10.1055","volume":"52","author":[{"given":"Thomas","family":"Cloppenborg","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, Krankenhaus Mara, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Albers","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, Krankenhaus Mara, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Kalbhenn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Evangelisches Klinikum Bethel, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich G.","family":"Woermann","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, Krankenhaus Mara, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Bien","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, Krankenhaus Mara, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Polster","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, Krankenhaus Mara, Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"issue":"07","key":"ref1","first-page":"CD010541","article-title":"Surgery for epilepsy","volume":"7","author":"S West","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/brain\/124.9.1683","article-title":"Presurgical evaluation of epilepsy","volume":"124","author":"F Rosenow","year":"2001","journal-title":"Brain"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/epi.12544","article-title":"Diagnostic test utilization in evaluation for resective epilepsy surgery in children","volume":"55","author":"P Jayakar","year":"2014","journal-title":"Epilepsia"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1528-1157.1970.tb03865.x","article-title":"Criteria for identifying cingulate 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ictal pouting (\u201cchapeau de gendarme\u201d) in frontal lobe epilepsy","volume":"37","author":"Z Souirti","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/epi.14690","article-title":"Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: a review of 135 surgically treated cases","volume":"60","author":"S A Gibbs","year":"2019","journal-title":"Epilepsia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.seizure.2018.08.026","article-title":"Lateralizing and localizing value of seizure semiology: comparison with scalp EEG, MRI and PET in patients successfully treated with resective epilepsy surgery","volume":"61","author":"S Elwan","year":"2018","journal-title":"Seizure"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League against Epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"R S Fisher","year":"2017","journal-title":"Epilepsia"}],"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1715630.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:56:18Z","timestamp":1611795378000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1715630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":11,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,1,27]]},"published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1715630","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]}}}