{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:55:38Z","timestamp":1771660538666,"version":"3.50.1"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>\n            Introduction\u2003Data regarding transplacental passage of maternal coronavirus disease 2019 (COVID-19) antibodies and potential immunity in the newborn is limited.<\/jats:p><jats:p>\n            Case Report\u2003We present a 25-year-old multigravida with known red blood cell isoimmunization, who was found to be COVID-19 positive at 27 weeks of gestation while undergoing serial periumbilical blood sampling and intrauterine transfusions. Maternal COVID-19 antibody was detected 2 weeks after positive molecular testing. Antibodies were never detected on cord blood samples from two intrauterine fetal cord blood samples as well as neonatal cord blood at the time of delivery.<\/jats:p><jats:p>\n            Conclusion\u2003This case demonstrates a lack of passive immunity of COVID-19 antibodies from a positive pregnant woman to her fetus, neither in utero nor at the time of birth. Further studies are needed to understand if passage of antibodies can occur and if that can confer passive immunity in the newborn.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1715643","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T22:46:30Z","timestamp":1597358790000},"page":"1280-1282","source":"Crossref","is-referenced-by-count":15,"title":["A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient"],"prefix":"10.1055","volume":"37","author":[{"given":"Lorraine E.","family":"Toner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari E.","family":"Gelber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan S.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Rebarber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1055\/s-0040-1712529","article-title":"COVID-19 in pregnant women: case series from one large new york city obstetrical practice","volume":"37","author":"N S Fox","year":"2020","journal-title":"Am J Perinatol"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMc2005073","article-title":"SARS-CoV-2 infection in children","volume":"382","author":"X Lu","year":"2020","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records","volume":"395","author":"H Chen","year":"2020","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7233","article-title":"Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection","author":"D Baud","year":"2020","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4861","article-title":"Antibodies in infants born to mothers with COVID-19 pneumonia","author":"H Zeng","year":"2020","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3389\/fimmu.2017.01294","article-title":"Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy","volume":"8","author":"C R Wilcox","year":"2017","journal-title":"Front Immunol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cell.2019.05.046","article-title":"Fc IgG in HIV-infected women","volume":"178","author":"D R Martinez","year":"2019","journal-title":"Cell"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1715643.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T22:34:33Z","timestamp":1601937273000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1715643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":7,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,10,5]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1715643","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]}}}