{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:53:44Z","timestamp":1783148024438,"version":"3.54.6"},"reference-count":81,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute viral bronchiolitis (AVB) is the leading cause of hospital admissions among infants in developed and developing countries and associated with increased morbidity and cost of treatment. This review was performed to guide the clinicians managing AVB in light of evidence accumulated in the last decade. We searched published English literature in last decade regarding etiology, diagnosis, treatment, and prevention of AVB using PubMed and Cochrane Database of Systematic Reviews. Respiratory syncytial virus is the most common causative agent. The diagnosis is mainly clinical with limited role of diagnostic investigations and chest radiographs are not routinely indicated. The management of AVB remains a challenge, as the role of various interventions is not clear. Supportive care in form of provision of heated and humidified oxygen and maintaining hydration are main interventions. The use of pulse oximetry helps to guide the administration of oxygen. Trials and systematic reviews evaluated various interventions like nebulized adrenaline, bronchodilators and hypertonic saline, corticosteroids, different modes of noninvasive ventilation (high-flow nasal cannula [HFNC], continuous positive airway pressure [CPAP], and noninvasive positive pressure ventilation [NPPV]), surfactant, heliox, chest physiotherapy, and antiviral drugs. The interventions which showed some benefits in infants and children with AVB are adrenaline and hypertonic saline nebulization, HFNC, CPAP, NIV, and surfactant. The routine administration of antibiotics, bronchodilators, corticosteroids, steam inhalation, chest physiotherapy, heliox, and antiviral drugs are not recommended.<\/jats:p>","DOI":"10.1055\/s-0040-1715852","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:08:52Z","timestamp":1599073732000},"page":"079-086","source":"Crossref","is-referenced-by-count":17,"title":["Acute Viral Bronchiolitis: A Narrative Review"],"prefix":"10.53391","volume":"12","author":[{"given":"Suresh K.","family":"Angurana","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijai","family":"Williams","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Gleneagles Global Hospitals, Perumbakkam, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Takia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31409","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/bmb\/61.1.13","article-title":"The pathogenesis of respiratory syncytial virus disease in childhood","volume":"61","author":"P S McNamara","year":"2002","journal-title":"Br Med Bull"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis","volume":"134","author":"S L 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