{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:39:15Z","timestamp":1761061155765},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The present study aimed to compare the effectiveness and safety of low molecular-weight-heparin (LMWH) and unfractionated heparin (UFH) in acute myocardial infarction (AMI) patients receiving intra-aortic balloon counterpulsation (IABP).<\/jats:p><jats:p>\n          Materials and Methods\u2003We retrospectively analyzed a total of 344 patients receiving IABP for cardiogenic shock, severe heart failure, ventricular septal rupture, or mitral valve prolapse due to AMI. A total of 161 patients received UFH (a bolus injection 70 U\/kg immediately after IABP, followed by infusion at a rate of 15 U\/kg\/hour and titration to for 50 to 70\u2009seconds of activated partial thromboplastin time. A total of 183 patients received LMWH (subcutaneous injection of 1.0\u2009mg\/kg every 12\u2009hours for 5 to 7 days and 1.0\u2009mg\/kg every 24\u2009hours thereafter). Events of ischemia, arterial thrombosis or embolism, and bleeding during IABP were evaluated. Major bleeding was defined as a hemoglobin decrease by &gt;50\u2009g\/L (vs. prior to IABP) or bleeding that caused hemodynamic shock or life-threatening or requiring blood transfusion.<\/jats:p><jats:p>\n          Results\u2003Subjects receiving UFH and LMWH did not differ in baseline characteristics. Ischemia was noted in five (3.1%) and two (1.1%) subjects in UFH and LMWH groups, respectively. Arterial thromboembolism occurred in three (1.9%) subjects in the UFH group, but not in the LMWH group. Logistic regression analysis failed to reveal an association between ischemia or bleeding with heparin type. Major bleeding occurred in 16 (9.9%) and six (3.3%) patients in the UFH and LWMH groups, respectively (p\u2009=\u20090.014). Regression analysis indicated that LMWH is associated with less major bleeding.<\/jats:p><jats:p>\n          Conclusion\u2003LMWH could reduce the risk of major bleeding in patients receiving IABP. Whether LMWH could reduce arterial thromboembolism needs further investigation.<\/jats:p>","DOI":"10.1055\/s-0040-1716390","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T22:42:42Z","timestamp":1601505762000},"page":"511-517","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Safety between Different Kinds of Heparins in Patients Receiving Intra-Aortic Balloon Counterpulsation"],"prefix":"10.1055","volume":"69","author":[{"given":"Xiaonan","family":"Guan","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulei","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbing","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Beijing Chaoyang Hospital, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/CIRCULATIONAHA.108.814947","article-title":"Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective","volume":"119","author":"R J Goldberg","year":"2009","journal-title":"Circulation"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0735-1097(00)00814-7","article-title":"Platelet glycoprotein IIb\/IIIa blockade and outcome of cardiogenic shock complicating acute coronary syndromes without persistent ST-segment elevation","volume":"36","author":"D Hasdai","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(13)61783-3","article-title":"Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial","volume":"382","author":"H Thiele","year":"2013","journal-title":"Lancet"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ccd.1810110406","article-title":"Heparin elimination following continuous infusion during intra-aortic balloon counterpulsation","volume":"11","author":"A S Jacob","year":"1985","journal-title":"Cathet Cardiovasc Diagn"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"670S","DOI":"10.1378\/chest.08-0691","article-title":"Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition)","volume":"133","author":"R A Harrington","year":"2008","journal-title":"Chest"},{"issue":"17","key":"ref6","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/eurheartj\/ehm224","article-title":"Efficacy and safety of the low-molecular weight heparin enoxaparin compared with unfractionated heparin across the acute coronary syndrome spectrum: a meta-analysis","volume":"28","author":"S A Murphy","year":"2007","journal-title":"Eur Heart J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0140-6736(11)60876-3","article-title":"Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: the international randomised open-label ATOLL trial","volume":"378","author":"G Montalescot","year":"2011","journal-title":"Lancet"},{"issue":"02","key":"ref8","first-page":"203","article-title":"Enoxaparin in primary and facilitated percutaneous coronary intervention A formal prospective nonrandomized substudy of the FINESSE trial (Facilitated INtervention with Enhanced Reperfusion Speed to Stop Events)","volume":"3","author":"G Montalescot","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e835","DOI":"10.7717\/peerj.835","article-title":"Efficacy and safety of low molecular weight heparin compared to unfractionated heparin for chronic outpatient hemodialysis in end stage renal disease: systematic review and meta-analysis","volume":"3","author":"G Palamaner Subash Shantha","year":"2015","journal-title":"PeerJ"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1076029612463424","article-title":"Effect of unfractionated and low-molecular-weight heparin on OPG, sRANKL, and von Willebrand factor concentrations during hemodialysis","volume":"20","author":"K Klejna","year":"2014","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref11","first-page":"6","article-title":"Chinese experts' consensus: ST-segment elevation acute myocardial infarction prehospital thrombolytic therapy","volume":"10","author":"H B Yan","year":"2018","journal-title":"Chinese Journal of the Frontiers of Medical Science"},{"issue":"18","key":"ref12","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"K Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/CCM.0b013e3181b78671","article-title":"Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome","volume":"38","author":"R Prondzinsky","year":"2010","journal-title":"Crit Care Med"},{"issue":"33","key":"ref14","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"B Williams","year":"2018","journal-title":"Eur Heart J"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD","volume":"41","author":"F Cosentino","year":"2020","journal-title":"Eur Heart J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2019.08.014","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk","volume":"290","author":"F Mach","year":"2019","journal-title":"Atherosclerosis"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1010-7940(02)00034-9","article-title":"Vascular complications of intra-aortic balloon insertion in patients undergoing coronary reavscularization: analysis of 911 cases","volume":"21","author":"Z S Meharwal","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"issue":"09","key":"ref18","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.amjcard.2013.07.003","article-title":"A direct comparison of intravenous enoxaparin with unfractionated heparin in primary percutaneous coronary intervention (from the ATOLL trial)","volume":"112","author":"J-P Collet","year":"2013","journal-title":"Am J Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e553","DOI":"10.1136\/bmj.e553","article-title":"Efficacy and safety of enoxaparin versus unfractionated heparin during percutaneous coronary intervention: systematic review and meta-analysis","volume":"344","author":"J Silvain","year":"2012","journal-title":"BMJ"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/j.1538-7836.2011.04445.x","article-title":"Low-molecular-weight heparins vs. unfractionated heparin in the setting of percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis","volume":"9","author":"E P Navarese","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s11239-015-1294-3","article-title":"Nadroparin for the prevention of venous thromboembolism in nonsurgical patients: a systematic review and meta-analysis","volume":"42","author":"W Ageno","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"14","key":"ref22","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/CIRCULATIONAHA.108.828541","article-title":"Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC\/AHA Guidelines) Bleeding Score","volume":"119","author":"S Subherwal","year":"2009","journal-title":"Circulation"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jcin.2010.08.015","article-title":"Use of anticoagulant agents and risk of bleeding among patients admitted with myocardial infarction: a report from the NCDR ACTION Registry--GWTG (National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry--Get With the Guidelines)","volume":"3","author":"M B Kadakia","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/jama.1968.03140020041011","article-title":"Initial clinical experience with intraaortic balloon pumping in cardiogenic shock","volume":"203","author":"A Kantrowitz","year":"1968","journal-title":"JAMA"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","article-title":"Percutaneous mechanical circulatory support versus intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction","volume":"69","author":"D M Ouweneel","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ahj.2011.03.037","article-title":"A multicenter, randomized, controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size prepercutaneous coronary intervention for acute myocardial infarction: rationale and design of the Counterpulsation Reduces Infarct Size Acute Myocardial Infarction trial","volume":"162","author":"M R Patel","year":"2011","journal-title":"Am Heart J"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/icvts\/ivs017","article-title":"Is heparin needed for patients with an intra-aortic balloon pump?","volume":"15","author":"P H Pucher","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0003-4975(98)01272-7","article-title":"Vascular complications of the intraaortic balloon pump in patients undergoing open heart operations: 15-year experience","volume":"67","author":"O E Arafa","year":"1999","journal-title":"Ann Thorac Surg"},{"issue":"06","key":"ref29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00002480-200111000-00008","article-title":"Usefulness of the low profile \u201cTrue 8\u201d intra-aortic balloon pumping catheter for preventing limb lschemia","volume":"47","author":"S Kuki","year":"2001","journal-title":"ASAIO J"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1631\/jzus.2003.0607","article-title":"Anticoagulation therapy in intra-aortic balloon counterpulsation: does IABP really need anti-coagulation?","volume":"4","author":"C Y Jiang","year":"2003","journal-title":"J Zhejiang Univ Sci"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/clc.20297","article-title":"Safety of intra-aortic balloon pump using glycoprotein IIb\/IIIa antagonists","volume":"32","author":"A Laish-Farkash","year":"2009","journal-title":"Clin Cardiol"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/17482940802483048","article-title":"The role of heparin anticoagulation during intra-aortic balloon counterpulsation in the coronary care unit","volume":"10","author":"H A Cooper","year":"2008","journal-title":"Acute Card Care"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1097\/01.ASN.0000145014.80714.35","article-title":"Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: a meta-analysis of randomized trials","volume":"15","author":"W Lim","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2048872619894254","article-title":"Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: a document of the Acute Cardiovascular Care Association of the European Society of Cardiology","volume":"9","author":"U Zeymer","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","article-title":"Impella support for acute myocardial infarction complicated by cardiogenic shock","volume":"139","author":"B Schrage","year":"2019","journal-title":"Circulation"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/2048872618799745","article-title":"Survival after refractory cardiogenic shock is comparable in patients with Impella and veno-arterial extracorporeal membrane oxygenation when adjusted for SAVE score","volume":"8","author":"P Schiller","year":"2019","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s00392-019-01458-2","article-title":"Mechanical circulatory support with Impella versus intra-aortic balloon pump or medical treatment in cardiogenic shock-a critical appraisal of current data","volume":"108","author":"B Wernly","year":"2019","journal-title":"Clin Res Cardiol"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.thromres.2010.03.001","article-title":"Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention","volume":"126","author":"M Vlasin","year":"2010","journal-title":"Thromb Res"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000320164","article-title":"Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous formation of factor Xa and IIa and on thrombelastometry profiles in cord versus adult blood","volume":"100","author":"G Cvirn","year":"2011","journal-title":"Neonatology"},{"issue":"05","key":"ref40","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/1076029610376936","article-title":"Different effects of enoxaparin, nadroparin, and dalteparin on plasma TFPI during hemodialysis: a prospective crossover randomized study","volume":"17","author":"B Naumnik","year":"2011","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1716390.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:56:03Z","timestamp":1632264963000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1716390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":40,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1716390","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}