{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:24:47Z","timestamp":1777973087883,"version":"3.51.4"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The prognostic significance of serum biomarkers in patients with intracerebral hemorrhage (ICH) is not well investigated concerning inhospital mortality (IHM) and cardiopulmonary events within the first 24\u2009hours of intensive care unit (ICU) treatment. The influence of troponin I (TNI) value and cortisol value (CV) on cardiopulmonary events within the first 24\u2009hours of ICU treatment was reported in subarachnoid hemorrhage patients, but not in ICH patients up to now. The aim of this study was to investigate the role of early serum biomarkers on IHM and TNI value and CV on cardiopulmonary events within the first 24\u2009hours of ICU treatment.<\/jats:p><jats:p>\n          Patients and Methods\u2003A total of 329 patients with spontaneous ICH were retrospectively analyzed. Blood samples were taken on admission to measure serum biomarkers. The TNI value and CV were defined as biomarkers for cardiopulmonary stress. Demographic data, cardiopulmonary parameters, including norepinephrine application rate (NAR) in microgram per kilogram per minute and inspiratory oxygen fraction (FiO2) within the first 24\u2009hours, and treatment regime were analyzed concerning their impact on ICU treatment and in hospital outcome. Binary logistic analysis was used to identify independent prognostic factors for IHM.<\/jats:p><jats:p>\n          Results\u2003Patients with initially nonelevated CVs required higher NAR (p\u2009=\u20090.01) and FiO2 (p\u2009=\u20090.046) within the first 24\u2009hours of ICU treatment. Lower cholinesterase level (p\u2009=\u20090.004), higher NAR (p\u2009=\u20090.002), advanced age (p\u2009&lt;\u20090.0001), larger ICH volume (p\u2009&lt;\u20090.0001), presence of intraventricular hemorrhage (p\u2009=\u20090.007) and hydrocephalus (p\u2009=\u20090.009), raised level of C-reactive protein (p\u2009=\u20090.024), serum lactate (p\u2009=\u20090.003), and blood glucose (p\u2009=\u20090.05) on admission were significantly associated with IHM. In a multivariate model, age (odds ratio [OR]: 1.055; 95% confidence interval [CI]: 1.026\u20131.085; p\u2009&lt;\u20090.0001), ICH volume (OR: 1.016; CI: 1.008\u20131.025; p\u2009&lt;\u20090.0001), and Glasgow Coma Scale (GCS) score (OR: 0.680; CI: 0.605\u20130.764; p\u2009&lt;\u20090.0001) on admission as well as requiring NAR (OR: 1.171; CI: 1.026\u20131.337; p\u2009=\u20090.02) and FiO2 (OR: 0.951; CI: 0.921\u20130.983, p\u2009=\u20090.003) within the first 24\u2009hours were independent predictors of IHM.<\/jats:p><jats:p>\n          Conclusion\u2003Higher levels of C-reactive protein, serum lactate, blood glucose, and lower cholinesterase level on admission were significantly associated with IHM. Patients with initially nonelevated CVs required higher NAR and FiO2 within the first 24\u2009hours of ICU treatment. Furthermore, requiring an NAR\u2009&gt;\u20090.5 \u00b5g\/kg\/min or an FiO2\u2009&gt;\u20090.21 were identified as additional independent predictors for IHM. These results could be helpful to improve ICU treatment in ICH patients.<\/jats:p>","DOI":"10.1055\/s-0040-1716516","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T03:06:49Z","timestamp":1607483209000},"page":"138-146","source":"Crossref","is-referenced-by-count":10,"title":["Early Serum Biomarkers for Intensive Care Unit Treatment within the First 24 Hours in Patients with Intracerebral Hemorrhage"],"prefix":"10.1055","volume":"82","author":[{"given":"Michael","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universit\u00e4tsklinikum Giessen und Marburg Standort Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Naumann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universit\u00e4tsklinikum Giessen und Marburg Standort Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universit\u00e4tsklinikum Giessen und Marburg Standort Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Universit\u00e4tsklinikum Giessen und Marburg Standort Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/anec.12056","article-title":"Electrocardiographic abnormalities and elevated cTNT at admission for intracerebral hemorrhage: predictors for survival?","volume":"18","author":"C Hjalmarsson","year":"2013","journal-title":"Ann Noninvasive 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