{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:03:18Z","timestamp":1782712998219,"version":"3.54.5"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T00:00:00Z","timestamp":1599955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science, and the Cooperative Research Project Program of the Joint Usage\/Research Center at the Institute of Development, Aging and Cancer, Tohoku University","award":["19H03445"],"award-info":[{"award-number":["19H03445"]}]},{"name":"Japan Society for the Promotion of Science, and the Cooperative Research Project Program of the Joint Usage\/Research Center at the Institute of Development, Aging and Cancer, Tohoku University","award":["16H05163"],"award-info":[{"award-number":["16H05163"]}]},{"name":"Japan Society for the Promotion of Science, and the Cooperative Research Project Program of the Joint Usage\/Research Center at the Institute of Development, Aging and Cancer, Tohoku University","award":["16K08670"],"award-info":[{"award-number":["16K08670"]}]},{"name":"Japan Society for the Promotion of Science, and the Cooperative Research Project Program of the Joint Usage\/Research Center at the Institute of Development, Aging and Cancer, Tohoku University","award":["19K07437"],"award-info":[{"award-number":["19K07437"]}]},{"name":"Japan Society for the Promotion of Science, and the Cooperative Research Project Program of the Joint Usage\/Research Center at the Institute of Development, Aging and Cancer, Tohoku University","award":["18K08123"],"award-info":[{"award-number":["18K08123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arterial thrombus formation is thought to be initiated by platelet adhesion to the subendothelial matrix, but ruptured atherosclerotic plaques are characterized by substantial reduction of matrix proteins compared with stable plaques. Intraplaque erythrocytes and\/or fibrin have been reported in high-risk coronary plaques. The aims of the current study were to identify factors that provide scaffolds for platelets at the sites of ruptured coronary plaques and investigate depositions of iron and bilirubin as hemoglobin catabolites in the ruptured plaques. Histological characteristics of plaque components and the thrombus interface were examined in 73 acute coronary aspirated thrombi. Necrotic debris (95%), macrophages (95%), and cholesterin clefts (81%) were observed frequently at the ruptured plaque and thrombus interface. A fibrous matrix (47%), calcification (32%), and extracellular deoxyribonucleic acid (15%) were identified as small foci. Tissue factor was localized in the necrotic core and macrophages. Fibrin and von Willebrand factor were consistently deposited within the plaques and beneath platelet aggregations. The citrullinated histone H3-immunopositive area accounted for only 0.5% of the plaque area. Bilirubin and iron depositions were detected in approximately 20% of the plaques in addition to biliverdin reductase and ferritin expression in macrophages. Fibrin and von Willebrand factor rather than matrix proteins and neutrophil extracellular traps may be major adhesive molecules at the sites of ruptured plaques. Iron and bilirubin deposits may be markers for rupture-prone plaques.<\/jats:p>","DOI":"10.1055\/s-0040-1716539","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T22:35:21Z","timestamp":1600036521000},"page":"234-241","source":"Crossref","is-referenced-by-count":10,"title":["Pathological Features of Ruptured Coronary Plaque and Thrombus Interfaces: Fibrin and von Willebrand Factor as Platelet Scaffolds on Rupture Sites"],"prefix":"10.1055","volume":"121","author":[{"given":"Atsushi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Nishihira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"},{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, 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