{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:37:30Z","timestamp":1780079850062,"version":"3.54.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Among the potential diseases that present altered salivary flow and activity is Sj\u00f6gren syndrome. Sialendoscopy seems to be an important therapeutic option.<\/jats:p><jats:p>\n          Objective\u2003To compare the results obtained with sialendoscopy for improving salivary flow measured by scintigraphy in patients with primary Sj\u00f6gren syndrome to those obtained with other intraglandular washing solutions.<\/jats:p><jats:p>\n          Methods\u2003Patients from our institution's rheumatology clinic diagnosed with primary Sj\u00f6gren syndrome underwent parotid scintigraphy prior to the sialendoscopy procedure. During the sialendoscopy procedure, one of the parotid glands was randomized to receive a wash with saline while the other was washed with a corticosteroid solution. After 1 month, a new scintigraphy examination of the parotid glands was performed to observe the salivary flow for comparison.<\/jats:p><jats:p>\n          Results\u2003A total of 13 female patients with mean age of 53.38 years (range, 27\u201376 years) were included in this study. After sialendoscopy, 10 patients (76.92%) were observed to have improvement in salivary excretion with radiopharmaceutical during scintigraphy. When analyzing each gland that was treated separately (26 glands), after sialendoscopy, improvement was observed in 18 glands (69.23%), 8 treated with dexamethasone and 10 with saline solution in the wash. There was no improvement in 8 glands (30.77%).<\/jats:p><jats:p>\n          Conclusion\u2003This study demonstrates that sialendoscopy is as an important tool to improve salivary flow measured by scintigraphy in patients with primary Sjogren syndrome, increasing salivary excretion through dilation and consequent unblocking of the ducts. These data suggest that there is no statistically significant difference between intraductal washing solutions using saline or dexamethasone solution.<\/jats:p>","DOI":"10.1055\/s-0040-1716574","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T22:44:42Z","timestamp":1601505882000},"page":"e6-e11","source":"Crossref","is-referenced-by-count":3,"title":["Sialendoscopy for Improvement of Salivary Flow in Patients with Sj\u00f6gren Syndrome - Comparative Analysis of Intraglandular Washing Solutions"],"prefix":"10.1055","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-9000","authenticated-orcid":false,"given":"Gabriela Robaskewicz","family":"Pascoto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-9562","authenticated-orcid":false,"given":"Andrese Aline","family":"Gasparin","sequence":"additional","affiliation":[{"name":"Department of Reumatology, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-3664","authenticated-orcid":false,"given":"Ot\u00e1vio Bejzman","family":"Piltcher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-1090","authenticated-orcid":false,"given":"Gabriel","family":"Kuhl","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-2789","authenticated-orcid":false,"given":"Leandro Totti","family":"Cavazzola","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"S P Humphrey","year":"2001","journal-title":"J Prosthet Dent"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0757.2008.00263.x","article-title":"Xerostomia","volume":"48","author":"J W Eveson","year":"2008","journal-title":"Periodontol 2000"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1007\/s11136-013-0420-y","article-title":"Validation of the Chinese version of the Summated Xerostomia Inventory (SXI)","volume":"22","author":"S L He","year":"2013","journal-title":"Qual Life Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.14219\/jada.archive.2007.0358","article-title":"Dry mouth and its effects on the oral health of elderly people","volume":"138","author":"M D Turner","year":"2007","journal-title":"J Am Dent Assoc"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archinte.162.11.1293","article-title":"Cevimeline for the treatment of xerostomia in patients with Sj\u00f6gren syndrome: a randomized trial","volume":"162","author":"R S Fife","year":"2002","journal-title":"Arch Intern Med"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joms.2010.10.002","article-title":"Endoscopic treatment of salivary glands affected by autoimmune diseases","volume":"69","author":"R Shacham","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.coms.2009.04.005","article-title":"Diagnostic imaging in sialadenitis","volume":"21","author":"J Zenk","year":"2009","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00005537-200102000-00015","article-title":"Specificity of parotid sialendoscopy","volume":"111","author":"F Marchal","year":"2001","journal-title":"Laryngoscope"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/01.mlg.0000214665.74330.96","article-title":"A technical improvement in sialendoscopy to enter the salivary ducts","volume":"116","author":"C Chossegros","year":"2006","journal-title":"Laryngoscope"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archoto.2009.184","article-title":"Pediatric sialendoscopy: a 5-year experience at a single institution","volume":"136","author":"C Martins-Carvalho","year":"2010","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"01","key":"ref11","first-page":"e1","article-title":"[Salivary stones and stenosis. A comprehensive classification]","volume":"110","author":"F Marchal","year":"2009","journal-title":"Rev Stomatol Chir Maxillofac"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.autrev.2009.02.027","article-title":"Assessment of salivary gland function in Sj\u00f6gren's syndrome: the role of salivary gland scintigraphy","volume":"8","author":"F Vinagre","year":"2009","journal-title":"Autoimmun Rev"},{"issue":"02","key":"ref13","first-page":"81","article-title":"Salivary gland scintigraphy: the use of semiquantitative analysis for uptake and clearance","volume":"31","author":"I Loutfi","year":"2003","journal-title":"J Nucl Med Technol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1754-4505.2003.tb01667.x","article-title":"Dental status, xerostomia and the oral health-related quality of life of an elderly institutionalized population","volume":"23","author":"D Locker","year":"2003","journal-title":"Spec Care Dentist"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.radonc.2012.06.004","article-title":"Xerostomia: a day and night difference","volume":"104","author":"T Dijkema","year":"2012","journal-title":"Radiother Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0003-9969(80)90068-0","article-title":"A comparison of circadian variation in the flow rate and composition of stimulated human parotid, submandibular and whole salivas from the same individuals","volume":"25","author":"D B Ferguson","year":"1980","journal-title":"Arch Oral Biol"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1113\/jphysiol.1972.sp009721","article-title":"Circadian rhythms in human salivary flow rate and composition","volume":"220","author":"C Dawes","year":"1972","journal-title":"J Physiol"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1016\/j.bjoms.2012.08.004","article-title":"Stenoses of the salivary ducts-sialendoscopy based diagnosis and treatment","volume":"51","author":"T Kope\u0107","year":"2013","journal-title":"Br J Oral Maxillofac Surg"}],"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1716574.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T04:06:33Z","timestamp":1612238793000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1716574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":18,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1716574","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}