{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:36:54Z","timestamp":1740148614805,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003O objetivo do nosso estudo \u00e9 analisar os resultados cl\u00ednicos e funcionais do tratamento de les\u00f5es nas articula\u00e7\u00f5es do joelho com condr\u00f3citos aut\u00f3logos embebidos em arcabou\u00e7o de fibrina.<\/jats:p><jats:p>\n          M\u00e9todos\u2003O estudo foi realizado com 56 pacientes (36 homens e 20 mulheres) com idade m\u00e9dia de 36 anos; 6 indiv\u00edduos eram atletas profissionais. Os pacientes apresentavam les\u00f5es \u00fanicas, condrais ou osteocondrais (43 condrais, nove osteocondrais, 2 casos de osteocondrite dissecante e duas fraturas osteocondrais) no joelho, com 2 a 10\u2009cm2 de tamanho e\u2009\u2264\u200910\u2009mm de profundidade, sem sinais de osteoartrite. As les\u00f5es estavam localizadas na patela (8), no c\u00f4ndilo femoral medial (40), no c\u00f4ndilo femoral lateral (7) e na tr\u00f3clea (1). O per\u00edodo m\u00e9dio de acompanhamento foi de 3 anos (faixa de 1\u20136 anos). A evolu\u00e7\u00e3o cl\u00ednica foi avaliada pelos escores de Cincinnati e Knee Injury and Osteoarthritis Outcome (KOOS), 6 e 12 meses ap\u00f3s a cirurgia. O teste t de Student pareado foi utilizado para compara\u00e7\u00e3o dos achados pr\u00e9 e p\u00f3s-operat\u00f3rios.<\/jats:p><jats:p>\n          Resultados\u2003Os pacientes retomaram suas atividades di\u00e1rias 6 meses ap\u00f3s o implante. Os escores avaliados demonstraram a melhora em compara\u00e7\u00e3o ao estado pr\u00e9-cir\u00fargico (p\u2009&lt;\u20090,05). Al\u00e9m disso, os pacientes conseguiram realizar suas atividades esportivas com mais facilidade do que antes da cirurgia (p\u2009&lt;\u20090,05).<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003A cultura de condr\u00f3citos em fibrina pode proporcionar um microambiente favor\u00e1vel para a s\u00edntese de matriz extracelular e melhorar a condi\u00e7\u00e3o cl\u00ednica e a atividade dos pacientes 1 ano ap\u00f3s a cirurgia<\/jats:p>","DOI":"10.1055\/s-0040-1716764","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:36:21Z","timestamp":1604018181000},"page":"470-477","source":"Crossref","is-referenced-by-count":1,"title":["Tratamento de les\u00f5es condrais no joelho com condr\u00f3citos aut\u00f3logos embebidos em arcabou\u00e7o de fibrina. Avalia\u00e7\u00e3o cl\u00ednica e funcional"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-6119","authenticated-orcid":false,"given":"Eduardo","family":"Alvarez-Lozano","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Ortop\u00e9dica, Hospital Jose E Gonzalez, Universidad Auton\u00f3ma de Nuevo Leon, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3193-7539","authenticated-orcid":false,"given":"Herminia","family":"Martinez-Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidad Auton\u00f3ma de Nuevo Leon, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-2237","authenticated-orcid":false,"given":"Francisco","family":"Forriol","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidade San Pablo CEU, IMMA, Boadilla del Monte, Madri, Espanha"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00774-007-0802-8","article-title":"Present status of and future direction for articular cartilage repair","volume":"26","author":"S Wakitani","year":"2008","journal-title":"J Bone Miner Metab"},{"issue":"S 03","key":"ref2","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0020-1383(09)70005-1","article-title":"Growth factors in cartilage and meniscus repair","volume":"40","author":"F Forriol","year":"2009","journal-title":"Injury"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1302\/0301-620X.84B4.0840571","article-title":"Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee","volume":"84","author":"M Ochi","year":"2002","journal-title":"J Bone Joint Surg Br"},{"issue":"S 03","key":"ref4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2106\/00004623-200300003-00017","article-title":"Articular cartilage engineering with autologous chondrocyte transplantation. 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