{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:35:58Z","timestamp":1754109358480},"reference-count":44,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Background<\/jats:bold>\u2003Phenotyping dementia is always a complex task for a clinician. There is a need for more practical biomarkers to aid clinicians.<\/jats:p>\n<jats:p>\n<jats:bold>Objective<\/jats:bold>\u2003The aim of the study is to investigate the shape profile of corpus callosum (CC) in different phenotypes of dementia.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003Our study included patients who underwent neuroimaging in our facility as a part of clinical evaluation for dementia referred from Geriatric Clinic (2017\u20132018). We have analyzed the shape of CC and interpreted the finding using a seven-segment division.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003The sample included MPRAGE images of Alzheimer\u2019 dementia (AD) (<jats:italic>n<\/jats:italic> = 24), posterior cortical atrophy- Alzheimer\u2019 dementia (PCA-AD) (<jats:italic>n<\/jats:italic> = 7), behavioral variant of frontotemporal dementia (Bv-FTD) (<jats:italic>n<\/jats:italic> = 17), semantic variant frontotemporal dementia (Sv-FTD) (<jats:italic>n<\/jats:italic> = 11), progressive nonfluent aphasia (PNFA) (<jats:italic>n<\/jats:italic> = 4), Parkinson\u2019s disease dementia (PDD) (<jats:italic>n<\/jats:italic> = 5), diffuse Lewy body dementia (<jats:italic>n<\/jats:italic> = 7), progressive supranuclear palsy (PSP) (<jats:italic>n<\/jats:italic> = 3), and corticobasal degeneration (CBD) (<jats:italic>n<\/jats:italic> = 3). We found in posterior dementias such as AD and PCA-AD that there was predominant atrophy of splenium of CC. In Bv-FTD, the genu and anterior half of the body of CC was atrophied, whereas in PNFA, PSP, PDD, and CBD there was atrophy of the body of CC giving a dumbbell like profile.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Our study findings were in agreement with the anatomical cortical regions involved in different phenotypes of dementia. Our preliminary study highlighted potential usefulness of CC in the clinical setting for phenotyping dementia in addition to clinical history and robust biomarkers.<\/jats:p>","DOI":"10.1055\/s-0040-1716805","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T23:48:59Z","timestamp":1604533739000},"page":"185-192","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Shape Profile of Corpus Callosum As a Signature to Phenotype Different Dementia"],"prefix":"10.25259","volume":"12","author":[{"given":"Sandhya","family":"Mangalore","sequence":"first","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva Shanker Reddy","family":"Mukku","sequence":"additional","affiliation":[{"name":"Geriatric Clinic and Services, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sriharish","family":"Vankayalapati","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palanimuthu Thangaraju","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"Geriatric Clinic and Services, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Varghese","sequence":"additional","affiliation":[{"name":"Geriatric Clinic and Services, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"issue":"10","key":"10.1055\/s-0040-1716805\/ref-1","first-page":"851","article-title":"Localization of functional projections from corpus callosum to cerebral cortex","volume":"104","author":"Tan","year":"1991","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1055\/s-0040-1716805\/ref-2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13229-015-0030-3","article-title":"Erratum: sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder (Molecular Autism (2015) 6 (26))","volume":"6","author":"Nordahl","year":"2015","journal-title":"Mol Autism"},{"key":"10.1055\/s-0040-1716805\/ref-3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/brain\/112.3.799","article-title":"Hand and sex differences in the isthmus and genu of the human corpus callosum. 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