{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:06Z","timestamp":1759940466341,"version":"3.44.0"},"reference-count":23,"publisher":"Necmettin Erbakan University Press","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bronchiolitis is a common pediatric intensive care unit (PICU) illness and often affects generally healthy children, making it a promising disease in which to study long-term neurodevelopmental outcomes. We previously found that approximately 15% of critical bronchiolitis patients have evidence of post-PICU morbidity using coarse definitions available in administrative data sets. In this study, we measured neurodevelopmental outcomes using four more precise tools. Children who had previously been admitted to our PICU with bronchiolitis were included; those with evidence of developmental delay at PICU admission were excluded. Approximately 1 to 2 years after PICU discharge, the parent of each subject completed two questionnaires (Ages and Stages Questionnaire and Pediatric Evaluation of Disability Inventory Computer Adaptive Test). Each subject also underwent two in-person assessments administered by a certified examiner (Bayley Scales of Infant and Toddler Development, 3rd edition, and the Amiel-Tison neurological assessment). For each domain of each test, a score of\u2009&gt;\u20091 standard deviation below the norm for the subject's age defined \u201cmoderate\u201d disability and a score \u2265 2 standard deviations below the norm defined \u201csevere\u201d disability. Eighteen subjects (median ages of 3.7 months at PICU admission and 2.3 years at testing) were enrolled, 17 of whom were supported by high-flow nasal cannula and\/or mechanical ventilation. Fifteen children (83%) scored abnormally on \u2265 1test. Eight children (44%) had disabilities in \u2265 3 domains and\/or \u2265 1 severe disability identified. Our findings that motor, language, and cognitive disabilities are commonly observed months to years after critical bronchiolitis require larger studies to confirm this finding, assess causality, and identify modifiable risk factors.<\/jats:p>","DOI":"10.1055\/s-0040-1716856","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T18:57:18Z","timestamp":1600455438000},"page":"282-288","source":"Crossref","is-referenced-by-count":10,"title":["Long-Term Neurodevelopmental and Functional Outcomes of Normally Developing Children Requiring PICU Care for Bronchiolitis"],"prefix":"10.53391","volume":"10","author":[{"given":"Steven L.","family":"Shein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Pace","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine N.","family":"Slain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanne","family":"Wilson-Costello","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S2352-4642(20)30170-X","article-title":"Post-intensive care syndrome in paediatrics: setting our sights on survivorship","volume":"4","author":"M Rodriguez-Rubio","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/PCC.0000000000000199","article-title":"Risk factors for acquiring functional and cognitive disabilities during admission to a PICU*","volume":"15","author":"M F Bone","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1542\/peds.2006-1455","article-title":"Outcome at 6 months after admission for pediatric intensive care: a report of a national study of pediatric intensive care units in the United kingdom","volume":"118","author":"S Jones","year":"2006","journal-title":"Pediatrics"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/CIR.0b013e318265ee8a","article-title":"Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association","volume":"126","author":"B S Marino","year":"2012","journal-title":"Circulation"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11065-017-9365-1","article-title":"Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes","volume":"28","author":"H A Marusak","year":"2018","journal-title":"Neuropsychol Rev"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/CCM.0b013e318275d032","article-title":"Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children","volume":"41","author":"L C Als","year":"2013","journal-title":"Crit Care Med"},{"issue":"16","key":"ref7","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1089\/neu.2012.2403","article-title":"Functional recovery ten years after pediatric traumatic brain injury: outcomes and predictors","volume":"29","author":"C Catroppa","year":"2012","journal-title":"J Neurotrauma"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"e20193611","DOI":"10.1542\/peds.2019-3611","article-title":"Respiratory syncytial virus-associated hospitalizations among young children: 2015-2016","volume":"146","author":"B Rha","year":"2020","journal-title":"Pediatrics"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/cc4984","article-title":"Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review","volume":"10","author":"M Eisenhut","year":"2006","journal-title":"Crit Care"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12890-017-0475-6","article-title":"Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation","volume":"17","author":"P Cruces","year":"2017","journal-title":"BMC Pulm Med"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"e606","DOI":"10.1097\/PCC.0000000000001351","article-title":"Temporal changes in prescription of neuropharmacologic drugs and utilization of resources related to neurologic morbidity in mechanically ventilated children with bronchiolitis","volume":"18","author":"S L Shein","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1183\/20734735.0013-2019","article-title":"Post-intensive care syndrome: impact, prevention, and management","volume":"15","author":"G A Colbenson","year":"2019","journal-title":"Breathe (Sheff)"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/PCC.0000000000001337","article-title":"Neurologic and functional morbidity in critically ill children with bronchiolitis","volume":"18","author":"S L Shein","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"e20161405","DOI":"10.1542\/peds.2016-1405","article-title":"Survival and neurodevelopmental outcomes of preterms resuscitated with different oxygen fractions","volume":"138","author":"N Boronat","year":"2016","journal-title":"Pediatrics"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cch.12397","article-title":"The psychometric properties of the Ages & Stages Questionnaires for ages 2-2.5: a systematic review","volume":"43","author":"T Velikonja","year":"2017","journal-title":"Child Care Health Dev"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1469-8749.2011.04107.x","article-title":"Accuracy and precision of the Pediatric Evaluation of Disability Inventory computer-adaptive tests (PEDI-CAT)","volume":"53","author":"S M Haley","year":"2011","journal-title":"Dev Med Child Neurol"},{"issue":"33","key":"ref17","first-page":"2143","article-title":"Neurologic examination of the newborn infant [in French]","volume":"27","author":"C Amiel-Tison","year":"1977","journal-title":"Rev Prat"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/pr.2014.10","article-title":"Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used?","volume":"75","author":"S Johnson","year":"2014","journal-title":"Pediatr Res"},{"issue":"08","key":"ref19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/jp.2014.67","article-title":"Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III","volume":"34","author":"L F Chalak","year":"2014","journal-title":"J Perinatol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00130478-200201000-00001","article-title":"Quality of life of survivors of pediatric intensive care","volume":"3","author":"A L Morrison","year":"2002","journal-title":"Pediatr Crit Care Med"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/01.inf.0000143654.12493.c9","article-title":"Detection of subgroup B respiratory syncytial virus in the cerebrospinal fluid of a patient with respiratory syncytial virus pneumonia","volume":"23","author":"K T Zlateva","year":"2004","journal-title":"Pediatr Infect Dis J"},{"issue":"22","key":"ref22","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1073\/pnas.1217508110","article-title":"Impaired learning resulting from respiratory syncytial virus infection","volume":"110","author":"J A Espinoza","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1097\/PCC.0000000000000850","article-title":"Temporal trends of respiratory syncytial virus-associated hospital and ICU admissions across the United States","volume":"17","author":"P Gupta","year":"2016","journal-title":"Pediatr Crit Care Med"}],"container-title":["Journal of Pediatric Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1716856.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:50:04Z","timestamp":1758138604000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1716856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":23,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1716856","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2146-4618","2146-4626"],"issn-type":[{"type":"print","value":"2146-4618"},{"type":"electronic","value":"2146-4626"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}