{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:39:12Z","timestamp":1789475952900,"version":"build-2803163510"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003The current understanding of Hirschsprung-associated enterocolitis (HAEC) is based mainly on single-center, retrospective studies. The aims of this study are to determine risk factors for postoperative HAEC using the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) database.<\/jats:p><jats:p>\n          Materials and Methods\u2003We performed a multicenter, retrospective, case\u2013control study of children with Hirschsprung disease (HD) who had undergone a pull-through procedure and were evaluated at a PCPLC member site between February 2017 and March 2020. The cohort with a history of postoperative HAEC was compared with that without postoperative episodes of HAEC to determine relevant associations with postoperative HAEC.<\/jats:p><jats:p>\n          Results\u2003One-hundred forty of 299 (46.8%) patients enrolled had a history of postoperative HAEC. Patients with a rectosigmoid transition zone had a lower association with postoperative HAEC as compared with those with a more proximal transition zone (odds ratio [OR]: 0.46, 95% confidence interval [CI]: 0.26, 0.84, p\u2009&lt;\u20090.01). Private insurance was protective against postoperative HAEC on univariate analysis (OR: 0.62, 95% CI: 0.38, 0.99, p\u2009=\u20090.047), but not on multivariate analysis (OR: 0.62, 95% CI: 0.37, 1.04, p\u2009=\u20090.07). Preoperative HAEC was not associated with the development of postoperative HAEC.<\/jats:p><jats:p>\n          Conclusion\u2003Patients with a rectosigmoid transition zone have less postoperative HAEC compared with patients with a more proximal transition zone. Multi-institutional collection of clinical information in patients with HD may allow for the identification of additional risk factors for HAEC and afford the opportunity to improve care.<\/jats:p>","DOI":"10.1055\/s-0040-1716876","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T22:55:30Z","timestamp":1600469730000},"page":"207-213","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of Hirschsprung Disease Characteristics between Those with a History of Postoperative Enterocolitis and Those without: Results from the Pediatric Colorectal and Pelvic Learning Consortium"],"prefix":"10.1055","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-8461","authenticated-orcid":false,"given":"Mark A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Utah School of Medicine and Primary Children's Hospital, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Bucher","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Utah School of Medicine and Primary Children's Hospital, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron W.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Avansino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Seattle Children's, Seattle, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Durham","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey M.","family":"Calkins","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Children's Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pediatric Colorectal and Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department Colorectal and Pelvic Reconstructive Surgery, Children's National Hospital, District of Columbia, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylea","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Utah School of Medicine and Primary Children's Hospital, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jpedsurg.2017.01.001","article-title":"A Nordic multicenter survey of long-term bowel function after transanal endorectal pull-through in 200 patients with rectosigmoid Hirschsprung disease","volume":"52","author":"K Bj\u00f8rnland","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00383-017-4066-7","article-title":"Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease","volume":"33","author":"J C Langer","year":"2017","journal-title":"Pediatr Surg Int"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1016\/j.jpedsurg.2018.08.024","article-title":"Prevention and management of recurrent postoperative Hirschsprung's disease obstructive symptoms and enterocolitis: systematic review and meta-analysis","volume":"53","author":"H J Soh","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jpedsurg.2008.10.052","article-title":"Development of a standardized definition for Hirschsprung's-associated enterocolitis: a Delphi analysis","volume":"44","author":"A C Pastor","year":"2009","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jpedsurg.2017.07.009","article-title":"Critical evaluation of the Hirschsprung-associated enterocolitis (HAEC) score: a multicenter study of 116 children with Hirschsprung disease","volume":"53","author":"P K Frykman","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1055\/s-0038-1677046","article-title":"Reliability of the Hirschsprung-associated enterocolitis score in clinical practice","volume":"29","author":"M Dore","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jpedsurg.2019.01.026","article-title":"Factors influencing the incidence of Hirschsprung associated enterocolitis (HAEC)","volume":"54","author":"A Le-Nguyen","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jpedsurg.2017.07.010","article-title":"Comparison of Hirschsprung-associated enterocolitis following Soave and Duhamel procedures","volume":"53","author":"I G Parahita","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00383-018-4393-3","article-title":"Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung's disease","volume":"35","author":"P HY Chung","year":"2019","journal-title":"Pediatr Surg Int"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jpedsurg.2007.10.007","article-title":"Hirschsprung disease: do risk factors of poor surgical outcome exist?","volume":"43","author":"A Pini Prato","year":"2008","journal-title":"J Pediatr Surg"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.jpedsurg.2017.03.056","article-title":"Pathologically assessed grade of Hirschsprung-associated enterocolitis in resected colon in children with Hirschsprung's disease predicts postoperative bowel function","volume":"52","author":"S Cheng","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jpedsurg.2010.11.014","article-title":"Redo pull-through in Hirschsprung's [corrected] disease for obstructive symptoms due to residual aganglionosis and transition zone bowel","volume":"46","author":"T A Lawal","year":"2011","journal-title":"J Pediatr Surg"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00383-011-2958-5","article-title":"Residual aganglionosis after pull-through operation for Hirschsprung's disease: a systematic review and meta-analysis","volume":"27","author":"F Friedmacher","year":"2011","journal-title":"Pediatr Surg Int"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpedsurg.2013.09.034","article-title":"The problematic Soave cuff in Hirschsprung disease: manifestations and treatment","volume":"49","author":"B H Dickie","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.jpedsurg.2016.09.026","article-title":"Enterocolitis and bowel function in children with Hirschsprung disease and trisomy 21","volume":"51","author":"N Kwendakwema","year":"2016","journal-title":"J Pediatr Surg"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10151-018-1782-5","article-title":"The Pediatric Colorectal and Pelvic Learning Consortium (PCPLC): rationale, infrastructure, and initial steps","volume":"22","author":"R W Reeder","year":"2018","journal-title":"Tech Coloproctol"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11605-017-3596-6","article-title":"Prevalence, risk factors, and prognosis of postoperative complications after surgery for Hirschsprung disease","volume":"22","author":"W K Huang","year":"2018","journal-title":"J Gastrointest Surg"},{"issue":"08","key":"ref18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0022-3468(97)90686-2","article-title":"Hirschsprung's disease: a 20-year experience","volume":"32","author":"R Reding","year":"1997","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0022-3468(95)90334-8","article-title":"Enterocolitis associated with Hirschsprung's disease: a clinical histopathological correlative study","volume":"30","author":"E A Elhalaby","year":"1995","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00383-006-1639-2","article-title":"Long-term outcome of patients with enterocolitis complicating Hirschsprung's disease","volume":"22","author":"M Menezes","year":"2006","journal-title":"Pediatr Surg Int"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.sempedsurg.2012.07.006","article-title":"The pathogenesis of Hirschsprung's disease-associated enterocolitis","volume":"21","author":"K M Austin","year":"2012","journal-title":"Semin Pediatr Surg"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"e0124172","DOI":"10.1371\/journal.pone.0124172","article-title":"Characterization of bacterial and fungal microbiome in children with Hirschsprung disease with and without a history of enterocolitis: a multicenter study","volume":"10","author":"P K Frykman","year":"2015","journal-title":"PLoS One"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jpedsurg.2014.01.060","article-title":"Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung's disease","volume":"49","author":"J F Pierre","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00383-016-3862-9","article-title":"Established and emerging concepts in Hirschsprung's-associated enterocolitis","volume":"32","author":"A Gosain","year":"2016","journal-title":"Pediatr Surg Int"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/SLA.0000000000001695","article-title":"Bowel function and quality of life after transanal endorectal pull-through for Hirschsprung disease: controlled outcomes up to adulthood","volume":"265","author":"M I Neuvonen","year":"2017","journal-title":"Ann Surg"},{"key":"ref26","first-page":"141","article-title":"Persistence of enterocolitis following diversion of faecal stream in Hirschsprung's disease - a study of mucosal defence mechanisms","volume":"3","author":"T Fujimoto","year":"1988","journal-title":"Pediatr Surg Int"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/gut.33.6.801","article-title":"Mucosal immune defence mechanisms in enterocolitis complicating Hirschsprung's disease","volume":"33","author":"A Imamura","year":"1992","journal-title":"Gut"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00383-017-4065-8","article-title":"Guidelines for the diagnosis and management of Hirschsprung-associated enterocolitis","volume":"33","author":"A Gosain","year":"2017","journal-title":"Pediatr Surg Int"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"e13665","DOI":"10.1111\/nmo.13665","article-title":"Distinctive genetic variation of long-segment Hirschsprung's disease in Taiwan","volume":"31","author":"W Yang","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jss.2018.03.069","article-title":"Impaired growth outcomes in children with congenital colorectal diseases","volume":"229","author":"L V Veras","year":"2018","journal-title":"J Surg Res"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpedsurg.2012.10.021","article-title":"Primary payer status is significantly associated with postoperative mortality, morbidity, and hospital resource utilization in pediatric surgical patients within the United States","volume":"48","author":"M L Stone","year":"2013","journal-title":"J Pediatr Surg"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1716876.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T22:31:35Z","timestamp":1621549895000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1716876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":31,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,5,20]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1716876","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}