{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:16:10Z","timestamp":1792088170163,"version":"4.4.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Ischemia-reperfusion (I\/R) injury is a serious condition that can affect the success rate of microsurgical reconstructions of ischemic amputated limbs and complex tissue defects requiring free tissue transfers. The purpose of this study was to evaluate the effects of ischemic preconditioning (IPC) and C1 esterase inhibitor (C1-Inh) intravenous administration following I\/R injury in a rat skin flap model.<\/jats:p><jats:p>\n          Methods\u2003Superficial caudal epigastric skin flaps (3\u2009cm\u2009\u00d7\u20097\u2009cm) were performed on 50 Wistar rats that were randomly divided into five groups. Ischemia was not induced in the control group. All other flaps underwent 8\u2009hours of ischemia prior to revascularization: I\/R control group (8-hour ischemia), IPC group (preconditioning protocol\u2009+\u20098-hour ischemia), C1-Inh group (8-hour ischemia\u2009+\u2009C1-Inh), and IPC\u2009+\u2009C1-Inh group (preconditioning protocol\u2009+\u20098-hour ischemia\u2009+\u2009C1-Inh). Survival areas were macroscopically assessed after 1 week of surgery, and histopathological and biochemical evaluations were also measured.<\/jats:p><jats:p>\n          Results\u2003There were no significant differences in flap survival between the treatment groups that were suffering 8\u2009hours of ischemia and the control group. A significant increase in neovascularization and lower edema formation were observed in the IPC group compared with that in the I\/R group. Biochemical parameters did not show any significant differences.<\/jats:p><jats:p>\n          Conclusion\u2003Intravenous administration of C1-Inh did not significantly modulate I\/R-related damage in this experimental model, but further research is needed. On the other hand, IPC reduces tissue damage and improves neovascularization, confirming its potential protective effects in skin flaps following I\/R injury.<\/jats:p>","DOI":"10.1055\/s-0040-1717102","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T22:46:29Z","timestamp":1600987589000},"page":"242-248","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Ischemic Preconditioning and C1 Esterase Inhibitor Administration following Ischemia-Reperfusion Injury in a Rat Skin Flap Model"],"prefix":"10.1055","volume":"37","author":[{"given":"Inmaculada","family":"Masa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Casado-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Crespo-Lora","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7150-9758","authenticated-orcid":false,"given":"Alberto","family":"Ballest\u00edn","sequence":"additional","affiliation":[{"name":"Department of Microsurgery, Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"685e","DOI":"10.1097\/PRS.0b013e318230c57b","article-title":"Update on ischemia-reperfusion injury for the plastic surgeon: 2011","volume":"128","author":"W Z Wang","year":"2011","journal-title":"Plast Reconstr 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