{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:30:22Z","timestamp":1781173822376,"version":"3.54.1"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/100016606","name":"Riley Children's Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016606","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n            Objective\u2003Therapeutic hypothermia (TH) is currently the only effective therapy available to improve outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) and has maximal effect when initiated within 6\u2009hours of birth. Neonates affected by HIE are commonly born outside of cooling centers and transport is a barrier to timely initiation. In this study, we sought to determine if the initiation of servo-controlled TH in transport allowed neonates to reach target temperature earlier, without a significant delay in the transfer process, for both local and long-distance transport.<\/jats:p><jats:p>\n            Study Design\u2003In this single-center cohort study of neonates referred to a level IV neonatal intensive care unit for TH, we determined the chronologic age at which target temperature was reached for those cooled in transport. Short-term outcome measures were assessed, including survival, incidence of electrographic seizures, discharge feeding method, and length of hospitalization.<\/jats:p><jats:p>\n            Results\u2003In a study population of 85 neonates, those receiving TH during transport (n\u2009=\u200923), achieved target temperature (33\u201334\u00b0C) 77\u2009minutes sooner (230\u2009\u00b1\u200971 vs. 307\u2009\u00b1\u200979\u2009minutes of life (MOL); p\u2009&lt;\u20090.001). Locally transported neonates (&lt;15 miles) achieved target temperature 69\u2009minutes earlier (215\u2009\u00b1\u200948 vs. 284\u2009\u00b1\u200974 MOL; p\u2009&lt;\u20090.01). TH during long-distance transports allowed neonates to reach target temperature 81\u2009minutes sooner (213\u2009\u00b1\u200985 vs. 294\u2009\u00b1\u200979 MOL; p\u2009&lt;\u20090.01). Infants who were cooled in transport discharged 4 days earlier (13.7\u2009\u00b1\u20098 vs. 17.8\u2009\u00b1\u200913 days; p\u2009=\u20090.18) and showed a significantly higher rate of oral feeding at discharge (95 vs. 71%; p\u2009=\u20090.03).<\/jats:p><jats:p>\n            Conclusion\u2003For those starting TH in transport, time to target temperature was decreased. In our cohort, cooling in transport was associated with improved short-term outcomes, although additional studies are needed to correlate these findings with long-term outcomes.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1718372","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T22:48:13Z","timestamp":1602715693000},"page":"633-639","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic Hypothermia in Transport Permits Earlier Treatment Regardless of Transfer Distance"],"prefix":"10.1055","volume":"39","author":[{"given":"Rachel L.","family":"Leon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Krause","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Sides","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Koch","sequence":"additional","affiliation":[{"name":"Riley Hospital for Children at IU Health, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Trautman","sequence":"additional","affiliation":[{"name":"Indiana University Health Lifeline Transport Services, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Mietzsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"J J Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"L Liu","year":"2012","journal-title":"Lancet"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1161\/STROKEAHA.112.674481","article-title":"Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12\u2009hours in neonatal rats","volume":"43","author":"H Sabir","year":"2012","journal-title":"Stroke"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep","volume":"102","author":"A J Gunn","year":"1998","journal-title":"Pediatrics"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000353948","article-title":"Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns","volume":"104","author":"M Thoresen","year":"2013","journal-title":"Neonatology"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1203\/00006450-199909000-00005","article-title":"Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep","volume":"46","author":"A J Gunn","year":"1999","journal-title":"Pediatr Res"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs","volume":"99","author":"A J Gunn","year":"1997","journal-title":"J Clin Invest"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"M Thoresen","year":"1995","journal-title":"Pediatr Res"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1203\/00006450-200203000-00015","article-title":"Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats","volume":"51","author":"B P Wagner","year":"2002","journal-title":"Pediatr Res"},{"issue":"15","key":"ref10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"S Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00313599","article-title":"Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia","volume":"87","author":"C Coimbra","year":"1994","journal-title":"Acta Neuropathol"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"M Thoresen","year":"1996","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-3782(98)00033-4","article-title":"The \u2018pharmacology\u2019 of neuronal rescue with cerebral hypothermia","volume":"53","author":"A J Gunn","year":"1998","journal-title":"Early Hum Dev"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1203\/PDR.0b013e318174efdd","article-title":"Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia","volume":"64","author":"M Karlsson","year":"2008","journal-title":"Pediatr Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial","volume":"8","author":"D Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"P D Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"14","key":"ref17","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"D V Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jpeds.2010.03.030","article-title":"Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China","volume":"157","author":"W H Zhou","year":"2010","journal-title":"J Pediatr"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2004.06.014","article-title":"Moderate hypothermia in neonatal encephalopathy: efficacy outcomes","volume":"32","author":"D J Eicher","year":"2005","journal-title":"Pediatr Neurol"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/pr.2012.103","article-title":"Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial","volume":"72","author":"G Natarajan","year":"2012","journal-title":"Pediatr Res"},{"issue":"01","key":"ref21","first-page":"28","article-title":"How plans can improve outcomes and cut costs for preterm infant care","volume":"19","author":"M Kornhauser","year":"2010","journal-title":"Manag Care"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/jp.2009.168","article-title":"Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU","volume":"30","author":"K Fairchild","year":"2010","journal-title":"J Perinatol"},{"issue":"01","key":"ref23","first-page":"19","article-title":"Comparison of passive and servo-controlled active cooling for infants with hypoxic-ischemic encephalopathy during neonatal transfers","volume":"34","author":"N Goel","year":"2017","journal-title":"Am J Perinatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.earlhumdev.2017.06.011","article-title":"Servo controlled versus manual cooling methods in neonates with hypoxic ischemic encephalopathy","volume":"112","author":"A Buchiboyina","year":"2017","journal-title":"Early Hum Dev"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jpeds.2014.12.061","article-title":"A randomized clinical trial of therapeutic hypothermia mode during transport for neonatal encephalopathy","volume":"166","author":"V P Akula","year":"2015","journal-title":"J Pediatr"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1651-2227.2009.01303.x","article-title":"Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling","volume":"98","author":"B Hallberg","year":"2009","journal-title":"Acta Paediatr"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/jp.2012.144","article-title":"Therapeutic hypothermia during neonatal transport: data from the California Perinatal Quality Care Collaborative (CPQCC) and California Perinatal Transport System (CPeTS) for 2010","volume":"33","author":"V P Akula","year":"2013","journal-title":"J Perinatol"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1542\/peds.2013-1686","article-title":"Active versus passive cooling during neonatal transport","volume":"132","author":"R Chaudhary","year":"2013","journal-title":"Pediatrics"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"e0170100","DOI":"10.1371\/journal.pone.0170100","article-title":"Passive hypothermia (\u226535 - <36\u00b0C) during transport of newborns with hypoxic-ischaemic encephalopathy","volume":"12","author":"A Sellam","year":"2017","journal-title":"PLoS One"},{"issue":"06","key":"ref30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/jp.2012.138","article-title":"Passive cooling during transport of asphyxiated term newborns","volume":"33","author":"D O'Reilly","year":"2013","journal-title":"J Perinatol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/PCC.0000000000001339","article-title":"Feasibility and safety of controlled active hypothermia treatment during transport in neonates with hypoxic-ischemic encephalopathy","volume":"18","author":"E Szakmar","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jpeds.2011.08.004","article-title":"Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop","volume":"159","author":"R D Higgins","year":"2011","journal-title":"J Pediatr"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1718372.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T23:40:52Z","timestamp":1652485252000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1718372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":32,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,5,13]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1718372","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}