{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:32:15Z","timestamp":1770820335863,"version":"3.50.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CSL Behring, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular diseases (CVDs) are a major issue in aging patients with hemophilia (PWHs). Antithrombotic agents are widely used in the general population for CVD treatment, but this recommendation is not fully applicable to PWHs. To improve treatment strategies, a prospective case\u2013control study (COCHE) that analyzed CVD management and follow-up (2 years\/patient) in PWHs was performed in France from 2011 to 2018. In total, 68 PWHs (median age: 65 years [39\u201389]; 48 mild, 10 moderate, and 10 severe hemophilia) were included (n\u2009=\u200950 with acute coronary syndrome, n\u2009=\u200917 with atrial fibrillation, n\u2009=\u20091 with both). They were matched with 68 control PWHs without antithrombotic treatment. In our series, bleeding was significantly influenced by (1) hemophilia severity, with a mean annualized bleeding ratio significantly higher in COCHE patients than in controls with basal clotting factor level up to 20%, (2) antihemorrhagic regimen (on-demand vs. prophylaxis) in severe (hazard ratio [HR]\u2009=\u200916.69 [95% confidence interval, CI: 8.2\u201347.26]; p\u2009&lt;\u20090.0001) and moderate hemophilia (HR\u2009=\u200942.43 [95% CI: 1.86\u2013966.1]; p\u2009=\u20090.0028), (3) type of antithrombotic treatment in mild hemophilia, with a significantly higher risk of bleeding in COCHE patients than in controls for dual-pathway therapy (HR\u2009=\u200915.64 [95% CI: 1.57\u2013115.8]; p\u2009=\u20090.019), anticoagulant drugs alone (HR\u2009=\u20099.91 [95% CI: 1.34\u201373.47]; p\u2009=\u20090.0248), dual antiplatelet therapy (HR\u2009=\u20095.31 [95% CI: 1.23\u201322.92]; p\u2009=\u20090.0252), and single antiplatelet therapy (HR\u2009=\u20093.76 [95% CI: 1.13\u201312.55]; p\u2009=\u20090.0313); and (4) HAS-BLED score \u22653 (odds ratio [OR]\u2009=\u200933 [95% CI: 1.43\u2013761.2]; p\u2009=\u20090.0065). Gastrointestinal bleeding was also significantly higher in COCHE patients than in controls (OR\u2009=\u200915 [95% CI: 1.84\u2013268]; p\u2009=\u20090.0141). The COCHE study confirmed that antithrombotic treatments in PWHs are associated with increased bleeding rates in function of hemophilia-specific factors and also of known factors in the general population.<\/jats:p>","DOI":"10.1055\/s-0040-1718410","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T22:32:15Z","timestamp":1603578735000},"page":"287-296","source":"Crossref","is-referenced-by-count":24,"title":["Long-Term Antithrombotic Treatments Prescribed for Cardiovascular Diseases in Patients with Hemophilia: Results from the French Registry"],"prefix":"10.1055","volume":"121","author":[{"given":"Beno\u00eet","family":"Guillet","sequence":"first","affiliation":[{"name":"Centre R\u00e9gional de Traitement des Maladies H\u00e9morragiques, CHU de Rennes, et Universit\u00e9 de Rennes 1, France"},{"name":"CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail), Univ Rennes, UMR_S 1085, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Cayla","sequence":"first","affiliation":[{"name":"Service de Cardiologie CHU de N\u00eemes, Universit\u00e9 de Montpellier, Nimes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-0427","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Trillot","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Wibaut","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Falaise","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU La Timone, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Castet","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gautier","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9gol\u00e8ne","family":"Claeyssens","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, CHU de Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Schved","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement des H\u00e9mophiles, H\u00f4pital Saint-Eloi, CHRU de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"issue":"S 03","key":"ref1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2516.2008.01708.x","article-title":"Back to the future: a recent history of haemophilia treatment","volume":"14","author":"P M Mannucci","year":"2008","journal-title":"Haemophilia"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1046\/j.1365-2516.1998.00179.x","article-title":"Causes of death in Canadians with haemophilia 1980-1995","volume":"4","author":"I R 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