{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:55:53Z","timestamp":1787702153961,"version":"build-2784847793"},"reference-count":3,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"10","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present report describes the case of a 31-year-old primigravida, with dichorionic twins at 31 weeks. She presented with history of myalgia, jaundice, and abdominal discomfort. No flu-like symptoms as fever or cough. She was not aware of exposure to COVID-19. Normal blood pressure and O2 saturation. Laboratory tests showed platelet count of 218,000\u2009mm3, alanine aminotransferase (ALT) 558\u2009IU and serum creatinine 2.3\u2009mg\/dl. Doppler ultrasound in one twin was compatible with brain sparing. Partial hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome was the hypothesis, and a cesarean section was performed. On day 2, the white-cell count reached 33,730, with decreased consciousness and mild respiratory distress. Tomography revealed both lungs with ground-glass opacities. Swab for COVID-19 polymerase chain reaction (PCR) was positive. Thrombocytopenia in patients with COVID-19 appears to be multifactorial, similar to what occurs in preeclampsia and HELLP syndrome. We assume that the synergism of these pathophysiological mechanisms could accelerate the compromise of maternal conditions and could be a warning to the obstetric practice.<\/jats:p>","DOI":"10.1055\/s-0040-1718437","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T23:31:15Z","timestamp":1604187075000},"page":"669-671","source":"Crossref","is-referenced-by-count":8,"title":["Coronavirus 2019, Thrombocytopenia and HELLP Syndrome: Association or Coincidence?"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8063","authenticated-orcid":false,"given":"Luiz Felipe Bagnatori","family":"Braga","sequence":"additional","affiliation":[{"name":"Hospital Municipal Maternidade Escola de Vila Nova Cachoeirinha, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-1004","authenticated-orcid":false,"given":"Nelson","family":"Sass","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","article-title":"Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis","volume":"506","author":"G Lippi","year":"2020","journal-title":"Clin Chim Acta"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"M A Brown","year":"2018","journal-title":"Hypertension"},{"issue":"18","key":"ref3","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1056\/NEJMc2010472","article-title":"Immune thrombocytopenic purpura in a patient with Covid-19","volume":"382","author":"A A Zulfiqar","year":"2020","journal-title":"N Engl J Med"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/coronavirus-2019-thrombocytopenia-and-hellp-syndrome-association-or-coincidence\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1718437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:57:17Z","timestamp":1721336237000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/coronavirus-2019-thrombocytopenia-and-hellp-syndrome-association-or-coincidence\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":3,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,31]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1718437","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}