{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:06:52Z","timestamp":1790719612452,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to assess the association of tracheal intubation (TI) and where it is performed, and the number of TI attempts with death and\/or severe neurological injury (SNI) among preterm infants.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective cohort study of infants born 23 to 32 weeks, admitted to a single level-3 neonatal intensive care unit (NICU) between 2015 and 2018. Exposures were location of TI (delivery room [DR] vs. NICU) and number of TI attempts (1 vs. &gt;1). Primary outcome was death and\/or SNI (intraventricular hemorrhage grade 3\u20134 and\/or periventricular leukomalacia). Multivariable logistic regression analysis was used to assess association between exposures and outcomes and to adjust for confounders.<\/jats:p><jats:p>\n            Results\u2003Rate of death and\/or SNI was 2.5% (6\/240) among infants never intubated, 12% (13\/105) among NICU TI, 32% (31\/97) among DR TI, 20% (17\/85) among infants with one TI attempt and 23% (27\/117) among infants with &gt;1 TI attempt. Overall, median number of TI attempts was 1 (interquartile range [IQR]: 1\u20132). Compared with no TI, DR TI (adjusted odds ratio [AOR]: 9.04, 95% confidence interval [CI]: 3.21\u201328.84) and NICU TI (AOR: 3.42, 95% CI: 1.21\u201310.61) were associated with higher odds of death and\/or SNI. The DR TI was associated with higher odds of death and\/or SNI compared with NICU TI (AOR: 2.64, 95% CI: 1.17\u20136.22). The number of intubation attempts (1 vs. &gt;1) was not associated with death and\/or SNI (AOR: 0.95, 95% CI: 0.47\u20132.03).<\/jats:p><jats:p>\n            Conclusion\u2003The DR TI is associated with higher odds of death and\/or SNI compared with NICU TI, and may help identify higher risk infants. There was no association between the number of TI attempts and death and\/or SNI.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1718577","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T22:53:16Z","timestamp":1603147996000},"page":"776-785","source":"Crossref","is-referenced-by-count":15,"title":["Association of Delivery Room and Neonatal Intensive Care Unit Intubation, and Number of Tracheal Intubation Attempts with Death or Severe Neurological Injury among Preterm Infants"],"prefix":"10.1055","volume":"39","author":[{"given":"Anthony","family":"Debay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharina","family":"Patel","sequence":"additional","affiliation":[{"name":"McGill University Health Center Research Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Wintermark","sequence":"additional","affiliation":[{"name":"McGill University Health Center Research Institute, Montreal, Quebec, Canada"},{"name":"Department of Pediatrics, Montreal Children's Hospital - McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Claveau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital - McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Olivier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital - McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Beltempo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital - McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000349928","article-title":"European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants: 2013 update","volume":"103","author":"D G Sweet","year":"2013","journal-title":"Neonatology"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00003246-198406000-00006","article-title":"Physiologic changes associated with endotracheal intubation in preterm infants","volume":"12","author":"T A 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