{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:19:50Z","timestamp":1775855990529,"version":"3.50.1"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003The utility of mucous fistula refeeding (MFR) in neonates with short bowel syndrome is widely debated. Our purpose is to review MFR and outline methods, reported complications, and clinical outcomes (survival, weight gain, dependence on parenteral nutrition [PN], and time to enteral autonomy).<\/jats:p><jats:p>\n          Materials and Methods\u2003We performed a MEDLINE literature search and reference review from January 1980 to May 2020 for terms (\u201cmucous fistula re-feeding\u201d or \u201centeral re-feeding\u201d) and neonates. We included studies that utilized conventional MFR in the neonatal period. Non-English language articles were excluded.<\/jats:p><jats:p>\n          Results\u2003We identified 11 relevant articles. Internationally, there was no consensus on methods of MFR. A total of 197 neonates underwent MFR. Within a single study, four neonates developed major complications; however, the procedure was well tolerated without major complications in 10 of the 11 studies. A mortality of nine patients during MFR highlights the burden of disease within the study population; however, of these, only one was directly attributable to MFR. Minor complications were seldom quantified. Three studies demonstrated a higher rate of weight gain and shorter PN support versus controls. Neonates who underwent MFR had lower chance of anastomotic leak and quicker progression to full feed after reversal versus controls. The influence of microorganisms in MFR was only investigated in one study.<\/jats:p><jats:p>\n          Conclusion\u2003Current evidence suggests benefits of MFR; however, an international consensus is yet to be reached on the optimal method. A large prospective study investigating the influence of MFR on the enteric system is required.<\/jats:p>","DOI":"10.1055\/s-0040-1718751","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T23:37:36Z","timestamp":1605051456000},"page":"146-152","source":"Crossref","is-referenced-by-count":9,"title":["A Review on Safety and Outcomes of Mucous Fistula Refeeding in Neonates"],"prefix":"10.1055","volume":"32","author":[{"given":"Harmit","family":"Ghattaura","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Birmingham Children's Hospital, Birmingham, West Midlands, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manobi","family":"Borooah","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Birmingham Women's Hospital, Birmingham, West Midlands, United 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