{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:57:24Z","timestamp":1788857844003,"version":"build-2803163510"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["UMO-2015\/B\/NZ5\/02215"],"award-info":[{"award-number":["UMO-2015\/B\/NZ5\/02215"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Prothrombotic fibrin clot properties are associated with higher early mortality risk in acute pulmonary embolism (PE) patients. It is unknown whether different types of PE are associated with particular clot characteristics.<\/jats:p>\n                  <jats:p>Methods\u2003We assessed 126 normotensive, noncancer acute PE patients (median age: 59 [48\u201370] years; 52.4% males), who were categorized into central versus peripheral PE with or without concomitant deep vein thrombosis (DVT). Plasma fibrin clot permeability (K s), clot lysis time (CLT), thrombin generation, platelet-derived markers, and fibrinolytic parameters were measured on admission. Plasma fibrin clot morphology was assessed by scanning electron microscopy (SEM).<\/jats:p>\n                  <jats:p>Results\u2003Patients with central PE (n\u2009=\u200976; 60.3%) compared with peripheral PE (n\u2009=\u200950; 39.7%) had 17.8% higher K s and 14.3% shortened CLT (both p\u2009&lt;\u20090.01 after adjustment for potential confounders including fibrinogen), with no differences between segmental and subsegmental PE. SEM analysis demonstrated larger fibrin fiber diameter and pore size in central PE compared with peripheral PE (both p\u2009&lt;\u20090.01). For isolated PE, there was 23.3% higher K s in central PE than in peripheral PE (n\u2009=\u200924; 19%) with no differences in other variables. Central PE combined with DVT (n\u2009=\u200945; 35.7%), as compared with central isolated PE (n\u2009=\u200931; 24.6%), was associated with shortened CLT (all p\u2009&lt;\u20090.05).<\/jats:p>\n                  <jats:p>Conclusion\u2003Our findings suggest that looser fibrin networks composed of thicker fibers with increased susceptibility to lysis characterize patients with central PE, suggesting that fibrin clot phenotype affects the size of thrombi occluding the pulmonary arteries, highlighting the role of fibrin structures in thrombus formation and stability.<\/jats:p>","DOI":"10.1055\/s-0040-1718762","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T18:46:25Z","timestamp":1605293185000},"page":"529-537","source":"Crossref","is-referenced-by-count":10,"title":["Loose Fibrin Clot Structure and Increased Susceptibility to Lysis Characterize Patients with Central Acute Pulmonary Embolism: The Impact of Isolated Embolism"],"prefix":"10.1055","volume":"121","author":[{"given":"Micha\u0142","family":"Z\u0105bczyk","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland"},{"name":"Krakow Center for Medical Research and Technologies, John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Natorska","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland"},{"name":"Krakow Center for Medical Research and Technologies, John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Janion-Sadowska","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, The Faculty of Medicine and Health Sciences, The Jan Kochanowski University, Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Metzgier-Gumiela","sequence":"additional","affiliation":[{"name":"Intensive Care Cardiology Unit, Provincial Polyclinical Hospital, Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Polak","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Leszek Giec Upper-Silesian Medical Centre of the Silesian Medical University in Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Plens","sequence":"additional","affiliation":[{"name":"KCRI, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Janion","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, The Faculty of Medicine and Health Sciences, The Jan Kochanowski University, Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Skonieczny","sequence":"additional","affiliation":[{"name":"Intensive Care Cardiology Unit, Provincial Polyclinical Hospital, Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Mizia-Stec","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Leszek Giec Upper-Silesian Medical Centre of the Silesian Medical University in Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland"},{"name":"Krakow Center for Medical Research and Technologies, John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18028","DOI":"10.1038\/nrdp.2018.28","article-title":"Pulmonary embolism","volume":"4","author":"M V Huisman","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"04","key":"ref2","first-page":"756","article-title":"Venous thromboembolism (VTE) in Europe. 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St\u0119pniewski","year":"2018","journal-title":"Pol Arch Intern Med"},{"issue":"01","key":"ref36","first-page":"70","article-title":"Viscoelastic properties of plasma fibrin clots are similar in patients on rivaroxaban and vitamin K antagonists","volume":"70","author":"M Kopytek","year":"2019","journal-title":"J Physiol Pharmacol"},{"issue":"01","key":"ref37","first-page":"15","article-title":"Monocyte to large platelet ratio as a diagnostic tool for pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease","volume":"128","author":"A J Bia\u0142as","year":"2018","journal-title":"Pol Arch Intern Med"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1718762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T07:37:30Z","timestamp":1723880250000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1718762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":37,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,3,21]]},"published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1718762","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]}}}