{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:18:21Z","timestamp":1782260301591,"version":"3.54.5"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Objective\u2003This study aimed to compare neonatal and maternal outcomes between immediate and delayed prophylactic antibiotic administration after previable prelabor premature rupture of membranes (PROM) less than 24 weeks of gestation.<\/jats:p><jats:p>Study Design\u2003Retrospective cohort study of singleton pregnancies with PROM between 160\/7 and 236\/7 weeks of gestational age conducted at a single tertiary care referral center between June 2011 and December 2015. Patients with multiple gestations, fetal anomalies, those who elected augmentation, or with a contradiction to expectant management, such as suspected intra-amniotic infection or stillbirth, were excluded from the study. We compared pregnancy characteristics, maternal complications, and neonatal outcomes between women who received a course of antibiotics within 24\u2009hours of PROM and women who received antibiotics after 24\u2009hours of PROM. The primary outcome was neonatal survival to hospital discharge. Secondary outcomes included gestational age at delivery, time from PROM to delivery, neonatal birth weight, days in the neonatal intensive care unit (NICU), composite adverse neonatal outcomes, and maternal morbidity.<\/jats:p><jats:p>Results\u2003Ninety-four women met inclusion criteria, 57 (61%) received antibiotics within 24\u2009hours of PROM and 37 (39%) received antibiotics 24\u2009hours after PROM. Baseline maternal characteristics were similar in both groups. The mean gestational age at PROM was similar between groups at 20.8\u2009\u00b1\u20092.3 weeks in the immediate antibiotics group and 20.6\u2009\u00b1\u20092.1 weeks in the delayed antibiotics group (p\u2009=\u20090.48). Compared with delayed antibiotic administration, immediate antibiotic administration was not associated with a significant difference in latency time from PROM to delivery, rate of stillbirth, days in an ICU, or adverse neonatal outcomes. Maternal outcomes also did not differ significantly between groups. Neonatal birth weight was lower in the immediate antibiotics group (p\u2009=\u20090.012).<\/jats:p><jats:p>Conclusion\u2003Our data suggest that there is no maternal or neonatal benefit to immediate administration of latency antibiotics compared with delayed administration.<\/jats:p><jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0040-1718876","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T22:58:17Z","timestamp":1603407497000},"page":"671-676","source":"Crossref","is-referenced-by-count":7,"title":["Antibiotic Timing in Previable Prelabor Rupture of Membranes Less Than 24 Weeks of Gestation"],"prefix":"10.1055","volume":"39","author":[{"given":"Rubymel J.","family":"Knupp","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pederson","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Szychowski","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Etikala","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sinkey","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Wetta","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-2194","authenticated-orcid":false,"given":"Lorie M.","family":"Harper","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00404-011-2179-0","article-title":"Previable preterm rupture of membranes: gestational and neonatal outcomes","volume":"285","author":"M F Margato","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1515\/jpm-2016-0183","article-title":"Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability","volume":"45","author":"W H Sim","year":"2017","journal-title":"J Perinat Med"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"620.e1","DOI":"10.1016\/j.ajog.2008.07.008","article-title":"Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis","volume":"199","author":"C E Hutzal","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/jpm-2016-0341","article-title":"Perinatal outcomes after previable preterm premature rupture of membranes before 24 weeks of gestation","volume":"46","author":"V Kiver","year":"2018","journal-title":"J Perinat 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Scand"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1055\/s-0033-1360195","article-title":"Antibiotic therapy for premature rupture of membranes and preterm labor and effect on fetal outcome","volume":"73","author":"B Seelbach-Goebel","year":"2013","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3109\/14767058.2015.1035643","article-title":"Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks","volume":"29","author":"J S Esteves","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.gofs.2018.10.023","article-title":"Prise en charge ant\u00e9natale en cas de rupture pr\u00e9matur\u00e9e des membranes avant la viabilit\u00e9 f\u0153tale. RPC Rupture pr\u00e9matur\u00e9e des membranes avant terme CNGOF","volume":"46","author":"E Azria","year":"2018","journal-title":"Gyn\u00e9col Obst\u00e9t Fertil S\u00e9nol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1718876.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T11:23:27Z","timestamp":1696937007000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1718876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":10,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,5,13]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1718876","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}