{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:46:24Z","timestamp":1787287584287,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a case of a neonate born with kaposiform hemangioendothelioma (KHE), complicated by Kasabach-Merritt phenomenon (KMP) and other serious conditions, who was successfully treated with sirolimus. In addition to complications from thrombocytopenia and fluid overload, during the course of therapy, our patient experienced supratherapeutic drug levels at the commonly accepted starting dose of sirolimus. Patients with KHE and KMP should be closely monitored for potential complications of both the initial disease and unexpected side effects of treatments.<\/jats:p>","DOI":"10.1055\/s-0040-1718901","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:05Z","timestamp":1605571205000},"page":"e390-e394","source":"Crossref","is-referenced-by-count":19,"title":["Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate"],"prefix":"10.1055","volume":"10","author":[{"given":"Trevor B.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Speer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Greives","sequence":"additional","affiliation":[{"name":"Department of Pediatric Plastic Surgery, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna A.","family":"Goff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neethu M.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Neonatal\/Perinatal Medicine, University of Texas Health Science Center at Houston\/McGovern Medical School, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"issue":"04","key":"ref1","first-page":"321","article-title":"Kaposiform hemangioendothelioma of infancy and childhood. 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