{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:53:51Z","timestamp":1791071631886,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to assess the incidence and predictors of rebound in term and late-preterm infants with hemolytic hyperbilirubinemia postphototherapy.<\/jats:p><jats:p>\n            Study Design\u2003A 4-year retrospective data analysis of neonates with hemolytic indirect hyperbilirubinemia admitted to the neonatal intensive care unit (NICU) of Medina Maternity and Children's Hospital was conducted. Bilirubin rebound was defined as the return of total serum bilirubin (TSB) to phototherapy threshold within 72\u2009hours of postphototherapy.<\/jats:p><jats:p>\n            Results\u2003Of 386 identified neonates; 44 (11%) experienced rebound. Neonates in the rebound group demonstrated significantly higher levels of peak TSB, TSB at discontinuation of phototherapy, and lower value of relative TSB (difference between TSB at phototherapy termination and the American Academy of Pediatrics [AAP] threshold for phototherapy at concurrent age) compared with nonrebound group (p-value: &lt;0.001, &lt;0.001, and 0.007, respectively). Lower value of relative TSB at stoppage of phototherapy was the single independent predictor for rebound hyperbilirubinemia by mutivariate regression (p &lt; 0.001). A cut-off value for relative TSB at stoppage of phototherapy of 190 \u00b5mol\/L had 98% sensitivity and 32% specificity to predict rebound hyperbilirubinemia.<\/jats:p><jats:p>\n            Conclusion\u2003Relative TSB at phototherapy termination is the best predictor for postphototherapy rebound hyperbilirubinemia in neonates with hemolytic etiology.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1718946","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T13:38:58Z","timestamp":1606225138000},"page":"836-843","source":"Crossref","is-referenced-by-count":8,"title":["Risk Factors and Predictors of Rebound Hyperbilirubinemia in a Term and Late-Preterm Infant with Hemolysis"],"prefix":"10.1055","volume":"39","author":[{"given":"Hanaa","family":"Almohammadi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medina Maternity and Children's Hospital, Medina, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad","family":"Nasef","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medina Maternity and Children's Hospital, Medina, Kingdom of Saudi Arabia"},{"name":"Departement of Pediatrics, Faculty of Medicine, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Al-Harbi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medina Maternity and Children's Hospital, Medina, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Saidy","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medina Maternity and Children's Hospital, Medina, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-6290","authenticated-orcid":false,"given":"Islam","family":"Nour","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medina Maternity and Children's Hospital, Medina, Kingdom of Saudi Arabia"},{"name":"Departement of Pediatrics, Faculty of Medicine, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1542\/hpeds.2014-0074","article-title":"The utility of inpatient rebound bilirubin levels in infants readmitted after birth hospitalization for hyperbilirubinemia","volume":"5","author":"A Berkwitt","year":"2015","journal-title":"Hosp Pediatr"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/jamapediatrics.2017.5630","article-title":"Efficacy of subthreshold newborn phototherapy during the birth hospitalization in preventing readmission for phototherapy","volume":"172","author":"A C Wickremasinghe","year":"2018","journal-title":"JAMA Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.eplepsyres.2016.05.004","article-title":"Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy","volume":"124","author":"R D Maimburg","year":"2016","journal-title":"Epilepsy Res"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e20180648","DOI":"10.1542\/peds.2018-0648","article-title":"Childhood seizures after phototherapy","volume":"142","author":"T B Newman","year":"2018","journal-title":"Pediatrics"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"e20151354","DOI":"10.1542\/peds.2015-1354","article-title":"Retrospective cohort study of phototherapy and childhood cancer in Northern California","volume":"137","author":"T B Newman","year":"2016","journal-title":"Pediatrics"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/000992289303200502","article-title":"Phototherapy for neonatal nonhemolytic hyperbilirubinemia. 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