{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:39:31Z","timestamp":1778884771852,"version":"3.51.4"},"reference-count":60,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Hypoxic-ischemic encephalopathy (HIE) is the main cause of long-term neurodevelopmental morbidity in term born infants worldwide. Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia. Probably, the synergistic use of hypothermia associated with melatonin treatment may improve the neurological outcome in infants with HIE. In the past 20 years, the efficacy of melatonin in reducing oxidative stress has been demonstrated in animals; however, clinical trials with sufficient sample size of newborns are lacking to date. Since in 2000 we were among the first to study the neuroprotective properties of melatonin on infants, in this review, we want to summarize the advantages and limitations of the investigations conducted to date.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1719151","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T23:33:35Z","timestamp":1604187215000},"page":"824-829","source":"Crossref","is-referenced-by-count":12,"title":["Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-1759","authenticated-orcid":false,"given":"Gabriella","family":"D'angelo","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4464-9421","authenticated-orcid":false,"given":"Laura","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloisa","family":"Gitto","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"J J Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1442-200x.2005.02085.x","article-title":"The protective role of melatonin in experimental hypoxic brain damage","volume":"47","author":"F T\u00fct\u00fcnc\u00fcler","year":"2005","journal-title":"Pediatr Int"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.clp.2019.02.006","article-title":"Pharmacologic prevention and treatment of neonatal brain injury","volume":"46","author":"M A 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