{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T02:12:54Z","timestamp":1758161574013,"version":"3.44.0"},"reference-count":28,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was conducted to assess the relationship of vitamin D deficiency (VDD) with various demographic characteristics, laboratory parameters, and predictors of mortality. This prospective observational study was performed at pediatric intensive care unit (PICU) of a tertiary care hospital situated in north India. A total of 125 children admitted in PICU with age from 2 months to 14 years were analyzed. The subjects were classified as Vitamin D deficient (\u226420\u2009ng\/mL) and nondeficient (&gt;20\u2009ng\/mL). The relationship between VDD and predictors of mortality were analyzed using correlation and multivariate analysis. Respiratory system (40%) was most commonly involved. VDD was seen in 72% of the patients. There was statistically significant correlation of VDD with age (p\u2009=\u20090.019), season (p\u2009=\u20090.018), height (p\u2009=\u20090.005), and weight (p\u2009=\u20090.003). On multivariate analysis factors associated with VDD were age (odds ratio [OR]\u2009=\u20091.01, 95% confidence interval [CI] 1.00\u20131.03, p\u2009=\u20090.006), season (OR\u2009=\u20093.98, 95% CI 1.09\u201314.50, p\u2009=\u20090.036). VDD was also correlated to bacteriuria (p\u2009=\u20090.033), cardiovascular sequential sepsis-related organ failure assessment score (CV-SOFA score) (p\u2009=\u20090.001), and mechanical ventilation (p\u2009=\u20090.043). On multivariate analysis, factors associated with VDD were bacteriuria (OR\u2009=\u20094.88, 95% CI 1.04\u201322.89, p\u2009=\u20090.04), mechanical ventilation requirement (OR\u2009=\u20092.95, 95% CI 1.12\u20137.85, p\u2009=\u20090.029), and CV-SOFA score (OR\u2009=\u20092.33, 95% CI 1.14\u20134.76, p\u2009=\u20090.021). Median (interquartile range) duration of PICU stay in VDD patients was (3\u20137) days while in nondeficient patients it was (2\u20136) days (p\u2009=\u20090.107). VDD was a significant risk factor for the need of mechanical ventilation, bacteriuria, and mortality among patients in our cohort.<\/jats:p>","DOI":"10.1055\/s-0040-1719171","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T18:51:31Z","timestamp":1608749491000},"page":"054-061","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of Vitamin D Deficiency with Predictors of Mortality in Critically Ill Children at a Tertiary Care Centre in North India\u2014A Prospective, Observational Study"],"prefix":"10.53391","volume":"11","author":[{"given":"Shilpa","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurmeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitanjali","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaskirat Kaur","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(10)61461-4","article-title":"Causes of neonatal and child mortality in India: a nationally representative mortality survey","volume":"376","author":"D G Bassani","year":"2010","journal-title":"Lancet"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cellimm.2012.10.002","article-title":"Protective role of the vitamin D receptor","volume":"279","author":"L Yang","year":"2012","journal-title":"Cell 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