{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:27:04Z","timestamp":1677464824521},"reference-count":55,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Occurrences of suprasellar central nervous system (CNS) embryonal tumors in adults are extremely rare. Hemorrhagic onset is further uncommon, with only anecdotic cases reported in the literature. The authors describe the case of a 57-year-old man affected by a suprasellar CNS embryonal tumor, with hemorrhagic onset and a unique diffusion pattern along the optic pathways.<\/jats:p><jats:p>\n          Material and Methods\u2003A 57-year-old man presenting with acute visual acuity worsening and left homonymous hemianopia was referred to our hospital. Neuroradiologic studies demonstrated an infiltrating, high-grade lesion involving the optic chiasm and right retrochiasmatic pathways with a hemorrhagic area in the ipsilateral pulvinar.<\/jats:p><jats:p>\n          Results\u2003The patient underwent microsurgical biopsy. Pathologic assessment confirmed the diagnosis of CNS embryonal tumor, not otherwise specified (NOS) according to the 2016 World Health Organization (WHO) classification of CNS tumors. The patient was referred to a multimodal adjuvant treatment; he eventually died 4 months after surgery. Competent literature has been systematically reviewed in the light of the relevant changes made in the last version of the WHO classification.<\/jats:p><jats:p>\n          Conclusion\u2003Embryonal tumors should be considered in the differential diagnosis for sellar and suprasellar space-occupying lesions, despite the rarity of the disease and the uncommon features at time of presentation. As per our knowledge, this is the first case ever described of hemorrhagic suprasellar embryonal tumor with a diffusion pattern along white matter fibers. Histogenesis, biomolecular and neuroradiologic features, and classification of embryonal tumors are an open field of research, with considerable implications for the definition of better diagnostic pitfalls and therapeutic regimens.<\/jats:p>","DOI":"10.1055\/s-0040-1721022","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T23:59:38Z","timestamp":1611273578000},"page":"089-098","source":"Crossref","is-referenced-by-count":2,"title":["Hemorrhagic Suprasellar Central Nervous System Embryonal Tumor in an Adult: Uncommon Features of an Extremely Rare Neoplasm"],"prefix":"10.1055","volume":"83","author":[{"given":"Martina","family":"Piloni","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bailo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Raffaella","family":"Barzaghi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Callea","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarosa","family":"Terreni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Falini","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and CERMAC, Vita-Salute San Raffaele University, and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Castellano","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and CERMAC, Vita-Salute San Raffaele University, and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Mortini","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/1097-0142(197310)32:4<890::AID-CNCR2820320421>3.0.CO;2-O","article-title":"Primitive neuroectodermal tumors of the brain in children","volume":"32","author":"M N Hart","year":"1973","journal-title":"Cancer"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"D N Louis","year":"2007","journal-title":"Acta Neuropathol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00165168","article-title":"Primitive neuroectodermal tumours of the cerebrum. Pathology and treatment","volume":"3","author":"C C Gaffney","year":"1985","journal-title":"J Neurooncol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ijrobp.2005.09.026","article-title":"Supratentorial primitive neuroectodermal tumors (S-PNET) in children: a prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy","volume":"64","author":"M Massimino","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1020207902659","article-title":"Supratentorial primitive neuroectodermal tumors in adults","volume":"60","author":"D G Kim","year":"2002","journal-title":"J Neurooncol"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-007-9466-4","article-title":"A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature","volume":"86","author":"S Ohba","year":"2008","journal-title":"J Neurooncol"},{"issue":"901","key":"ref7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1259\/bjr\/47707206","article-title":"Primitive neuroectodermal tumour in a 60-year-old man: a case report and literature review","volume":"76","author":"M J Balafouta","year":"2003","journal-title":"Br J Radiol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0090-3019(83)90102-7","article-title":"Primitive neuroectodermal tumor in a 57-year-old man","volume":"20","author":"E H Bellis","year":"1983","journal-title":"Surg Neurol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jocn.2006.03.034","article-title":"Extracranial metastases of a supratentorial primitive neuroectodermal tumour","volume":"14","author":"S R Han","year":"2007","journal-title":"J Clin Neurosci"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11060-005-9041-9","article-title":"Long-term relapse-free survival with supratentorial primitive neuroectodermal tumor in an adult: a case report","volume":"77","author":"T Krampulz","year":"2006","journal-title":"J Neurooncol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2176\/nmc.26.30","article-title":"Primitive neuroectodermal tumor arising from the thalamus of an adult: case report","volume":"26","author":"J Kuratsu","year":"1986","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/1752-1947-6-361","article-title":"Supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature","volume":"6","author":"S Lawandy","year":"2012","journal-title":"J Med Case Reports"},{"issue":"817","key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1259\/0007-1285-69-817-1","article-title":"Computed tomography and magnetic resonance imaging findings in primitive neuroectodermal tumours in adults","volume":"69","author":"D Pickuth","year":"1996","journal-title":"Br J Radiol"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s007010050122","article-title":"An adult case of cerebral primitive neuroectodermal tumour","volume":"140","author":"N Sanno","year":"1998","journal-title":"Acta Neurochir (Wien)"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2176\/nmc.45.530","article-title":"Supratentorial primitive neuroectodermal tumor in an aged patient: case report","volume":"45","author":"T Shingu","year":"2005","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/0976-3147.131672","article-title":"Supratentorial primitive neuroectodermal tumor presenting with intracranial hemorrhage in adult","volume":"5","author":"B Abuzayed","year":"2014","journal-title":"J Neurosci Rural Pract"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jocn.2016.10.043","article-title":"Adult supratentorial primitive neuroectodermal tumour presenting as intracranial haemorrhage: case report","volume":"37","author":"S P Black-Tiong","year":"2017","journal-title":"J Clin Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1752-1947-7-86","article-title":"A supratentorial primitive neuroectodermal tumor presenting with intracranial hemorrhage in a 42-year-old man: a case report and review of the literature","volume":"7","author":"E K Papadopoulos","year":"2013","journal-title":"J Med Case Reports"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1677\/erc.0.0050303","article-title":"A pseudo-endocrine suprasellar tumour: review of primitive neuroectodermal tumours in adults","volume":"5","author":"J VJ Berwaerts","year":"1998","journal-title":"Endocr Relat Cancer"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ando.2012.02.001","article-title":"Primary sellar neuroblastoma. A new case and review of literature","volume":"73","author":"M Dupuy","year":"2012","journal-title":"Ann Endocrinol (Paris)"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11102-007-0081-3","article-title":"A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures","volume":"12","author":"J H Lin","year":"2009","journal-title":"Pituitary"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11102-005-3328-x","article-title":"Sellar neuroblastoma mimicking pituitary adenoma","volume":"8","author":"K Oyama","year":"2005","journal-title":"Pituitary"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12022-010-9140-9","article-title":"Primary sellar neuroblastoma presenting with syndrome of inappropriate secretion of anti-diuretic hormone","volume":"21","author":"B Radotra","year":"2010","journal-title":"Endocr Pathol"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00701-004-0479-x","article-title":"Primary sellar esthesioneuroblastoma","volume":"147","author":"T Sajko","year":"2005","journal-title":"Acta Neurochir (Wien)"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2214\/ajr.133.1.140","article-title":"Primary sellar-parasellar esthesioneuroblastoma","volume":"133","author":"M Sarwar","year":"1979","journal-title":"AJR Am J Roentgenol"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/01.rmr.0000224685.83629.18","article-title":"Nonadenomatous tumors of the pituitary and sella turcica","volume":"16","author":"B Y Huang","year":"2005","journal-title":"Top Magn Reson Imaging"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5858\/arpa.2014-0020-OA","article-title":"An algorithmic approach to sellar region masses","volume":"139","author":"B K Kleinschmidt-DeMasters","year":"2015","journal-title":"Arch Pathol Lab Med"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WNO.0000000000000312","article-title":"Suprasellar primitive neuroectodermal tumor in an adult","volume":"36","author":"A Espino Barros Palau","year":"2016","journal-title":"J Neuroophthalmol"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3171\/jns.1996.85.5.0953","article-title":"Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report","volume":"85","author":"B Lach","year":"1996","journal-title":"J Neurosurg"},{"issue":"06","key":"ref30","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3171\/jns.2004.101.6.1049","article-title":"Esthesioneuroblastoma of the pituitary gland: a clinicopathological entity? Case report and review of the literature","volume":"101","author":"L Mariani","year":"2004","journal-title":"J Neurosurg"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2990.2000.026002177.x","article-title":"Correspondence: aesthesioneuroblastoma arising in pituitary gland","volume":"26","author":"A Roy","year":"2000","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"09","key":"ref32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.clineuro.2009.06.011","article-title":"Sellar neuroblastoma mimicking a pituitary tumour: case report and review of the literature","volume":"111","author":"K Schmalisch","year":"2009","journal-title":"Clin Neurol Neurosurg"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11060-013-1163-x","article-title":"Adult primitive neuroectodermal tumors: the prognostic value of supratentorial location","volume":"114","author":"R Gandhi","year":"2013","journal-title":"J Neurooncol"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jocn.2013.07.025","article-title":"Adult supratentorial extra-pineal primitive neuro-ectodermal tumors","volume":"21","author":"Y C Zheng","year":"2014","journal-title":"J Clin Neurosci"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/cncr.26387","article-title":"Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)","volume":"118","author":"N R Smoll","year":"2012","journal-title":"Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/415436a","article-title":"Prediction of central nervous system embryonal tumour outcome based on gene expression","volume":"415","author":"S L Pomeroy","year":"2002","journal-title":"Nature"},{"issue":"04","key":"ref37","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.410390410","article-title":"Glial differentiation predicts poor clinical outcome in primitive neuroectodermal brain tumors","volume":"39","author":"A J Janss","year":"1996","journal-title":"Ann Neurol"},{"issue":"04","key":"ref38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.2005.02101.x","article-title":"Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients","volume":"46","author":"S Vis\u00e9e","year":"2005","journal-title":"Histopathology"},{"issue":"08","key":"ref39","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/MD.0000000000000051","article-title":"Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease","volume":"93","author":"L Chen","year":"2014","journal-title":"Medicine (Baltimore)"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s003810050418","article-title":"Supratentorial primitive neuroectodermal tumor in children: clinical features, treatment outcome and prognostic factors","volume":"15","author":"H J Yang","year":"1999","journal-title":"Childs Nerv Syst"},{"issue":"04","key":"ref41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/PAS.0b013e31820f1ce0","article-title":"Supratentorial primitive neuroectodermal tumors of the central nervous system in adults: molecular and histopathologic analysis of 12 cases","volume":"35","author":"M Gessi","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"02","key":"ref42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1148\/rg.2018170182","article-title":"Embryonal tumors of the central nervous system: from the radiologic pathology archives","volume":"38","author":"R Y Shih","year":"2018","journal-title":"Radiographics"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s002340100603","article-title":"Diffusion-weighted imaging and fluid attenuated inversion recovery imaging in the evaluation of primitive neuroectodermal tumors","volume":"43","author":"E Erdem","year":"2001","journal-title":"Neuroradiology"},{"issue":"06","key":"ref44","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002340000318","article-title":"Supratentorial primitive neuroectodermal tumours: diffusion-weighted MRI","volume":"42","author":"J Klisch","year":"2000","journal-title":"Neuroradiology"},{"issue":"01","key":"ref45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.crad.2006.09.008","article-title":"Paediatric PNET: pre-surgical MRI features","volume":"62","author":"A Chawla","year":"2007","journal-title":"Clin Radiol"},{"issue":"03","key":"ref46","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1148\/radiol.2363040856","article-title":"Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy","volume":"236","author":"A Kovanlikaya","year":"2005","journal-title":"Radiology"},{"issue":"02","key":"ref47","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1148\/radiol.2252011592","article-title":"Adult primitive neuroectodermal tumor: proton MR spectroscopic findings with possible application for differential diagnosis","volume":"225","author":"C Maj\u00f3s","year":"2002","journal-title":"Radiology"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PAS.0b013e318186235b","article-title":"Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor","volume":"33","author":"M Gessi","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"06","key":"ref49","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"D N Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"02","key":"ref50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00401-013-1228-0","article-title":"Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity","volume":"128","author":"A Korshunov","year":"2014","journal-title":"Acta Neuropathol"},{"key":"ref51","first-page":"6785459","article-title":"Disseminated cerebrospinal embryonal tumor in the adult","volume":"2016","author":"A Caporlingua","year":"2016","journal-title":"Case Rep Pathol"},{"key":"ref52","first-page":"X17745208","article-title":"Embryonal tumor with multilayered rosettes, C19MC-altered: report of an extremely rare malignant pediatric central nervous system neoplasm","volume":"5","author":"M U Tariq","year":"2017","journal-title":"SAGE Open Med Case Rep"},{"issue":"04","key":"ref53","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jocn.2004.07.014","article-title":"Primitive supratentorial neuroectodermal tumor in an adult","volume":"12","author":"A T Kouyialis","year":"2005","journal-title":"J Clin Neurosci"},{"issue":"07","key":"ref54","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/pbc.21899","article-title":"Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?","volume":"52","author":"S Biswas","year":"2009","journal-title":"Pediatr Blood Cancer"},{"issue":"05","key":"ref55","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3171\/jns.1994.81.5.0690","article-title":"Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy","volume":"81","author":"R J Packer","year":"1994","journal-title":"J Neurosurg"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1721022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:58:48Z","timestamp":1643763528000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1721022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":55,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1721022","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}