{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:06:17Z","timestamp":1773075977921,"version":"3.50.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Different combinations of irrigation solutions have been used in attempt to eradicate microorganisms for the prevention and treatment of prosthetic joint infections (PJIs). Clorpactin WCS-90 was evaluated as an alternative irrigation intraoperative technique for the treatment of PJI using both debridement, antibiotics, and implant retention (DAIR) and 2-stage total knee arthroplasty (TKA) procedures. We retrospectively reviewed PJIs irrigated with Clorpactin between January 2015 and January 2020. We found 13 patients who underwent a DAIR procedure for an acutely infected primary TKA, 18 patients underwent a 2-stage procedure for a chronically infected primary TKA, two patients underwent a DAIR procedure for an acutely infected revision TKA, and 18 patients underwent a 2-stage procedure for a chronically infected revision TKA. The odds of reinfection and need for additional surgery were analyzed at a mean follow-up of 20 to 26 months between groups. Only one patient (7.69%) became reinfected in the acute infected primary TKA group, three patients (16.67%) in the chronic infected primary TKA group, 0 patients (0%) in the acute infected revision TKA group, and six patients (33.33%) in the chronic infected revision TKA group. When the acute primary TKA infection group was compared with the chronic revision TKA infection group, the odds of reinfection (Chi-square test [\u03c72]\u2009=\u200921.7, df 3, p\u2009&lt;\u20090.001) and odds of additional surgery (\u03c72\u2009=\u200913.6, df 3, p\u2009&lt;\u20090.003) were significantly higher for the chronic revision TKA infection group. Overall, the reinfection rate for DAIR revisions was 6.67% (range\u2009=\u20090\u20137.69) and 2-stage revisions was 25.00% (range\u2009=\u200916.67\u201333.33). The use of Clorpactin WCS-90 irrigation prior to wound closure is a useful option for the treatment of acute and chronic knee PJIs. Our study provides evidence that infection eradication with the use of Clorpactin is comparable to other irrigation methods and surgical techniques in reported literature.<\/jats:p>","DOI":"10.1055\/s-0040-1721087","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T13:52:58Z","timestamp":1606225978000},"page":"874-883","source":"Crossref","is-referenced-by-count":2,"title":["Clorpactin: An Alternative Irrigation Method for Total Knee Arthroplasty Joint Infection Revisions"],"prefix":"10.1055","volume":"35","author":[{"given":"Keith","family":"Kotecki","sequence":"additional","affiliation":[{"name":"Valley Hospital Orthopedic Surgery Residency Program, Valley Hospital Medical Center, Las Vegas, Nevada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Bradford","sequence":"additional","affiliation":[{"name":"Valley Hospital Orthopedic Surgery Residency Program, Valley Hospital Medical Center, Las Vegas, Nevada"},{"name":"Department of Orthopedic Surgery, Nevada Orthopedic and Spine Center, Las Vegas, Nevada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5312\/wjo.v9.i4.60","article-title":"Why total knees fail: a modern perspective review","volume":"9","author":"Z C Lum","year":"2018","journal-title":"World J Orthop"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"A J Tande","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1302\/0301-620X.97B10.36475","article-title":"The management of an infected total knee arthroplasty","volume":"97-B","author":"T Gehrke","year":"2015","journal-title":"Bone Joint J"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"e0151537","DOI":"10.1371\/journal.pone.0151537","article-title":"Re-infection outcomes following one- and two-stage surgical revision of infected knee prosthesis: a systematic review and meta-analysis","volume":"11","author":"S K Kunutsor","year":"2016","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"b1773","DOI":"10.1136\/bmj.b1773","article-title":"Diagnosis and management of prosthetic joint infection","volume":"338","author":"P C Matthews","year":"2009","journal-title":"BMJ"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1007\/s11999-013-2882-1","article-title":"Clinical faceoff: One- versus two-stage exchange arthroplasty for prosthetic joint infections","volume":"471","author":"M D Wongworawat","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12178-018-9500-5","article-title":"New innovations in the treatment of PJI and biofilms-clinical and preclinical topics","volume":"11","author":"M Taha","year":"2018","journal-title":"Curr Rev Musculoskelet Med"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2217\/fmb.14.64","article-title":"Biofilms in periprosthetic orthopedic infections","volume":"9","author":"S J McConoughey","year":"2014","journal-title":"Future Microbiol"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/17453674.2014.966290","article-title":"The role of microbial biofilms in prosthetic joint infections","volume":"86","author":"H O Gbejuade","year":"2015","journal-title":"Acta Orthop"},{"issue":"03","key":"ref11","first-page":"169","article-title":"[Detection of biofilm formation by selected pathogens relevant to the food industry]","volume":"64","author":"L \u0160ilhov\u00e1-Hru\u0161kov\u00e1","year":"2015","journal-title":"Epidemiol Mikrobiol Imunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/0030-4220(60)90313-3","article-title":"The use of hypochlorite for the control of bleeding","volume":"13","author":"J Bunyan","year":"1960","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1472-765X.1998.00390.x","article-title":"Changes in the strength of attachment of micro-organisms to surfaces following treatment with disinfectants and cleansing agents","volume":"27","author":"P J Eginton","year":"1998","journal-title":"Lett Appl Microbiol"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00004630-199109000-00005","article-title":"Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award","volume":"12","author":"J P Heggers","year":"1991","journal-title":"J Burn Care Rehabil"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0022-5347(17)65884-1","article-title":"The use of clorpactin WCS-90 for routine bladder irrigations","volume":"82","author":"S D Graham","year":"1959","journal-title":"J Urol"},{"issue":"11","key":"ref17","first-page":"629","article-title":"Virucidal activity of WCS-90","volume":"5","author":"M Sanders","year":"1955","journal-title":"Antibiot Chemother (Northfield)"},{"key":"ref18","first-page":"210","article-title":"The influence of clorpactin WCS-90 on the bacterial complications of surgery","volume":"47","author":"M K Duval Jr","year":"1960","journal-title":"Surgery"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/archotol.1955.03830020039008","article-title":"Clorpactin WCS-90: a new antiseptic; preliminary report","volume":"62","author":"M Zwerling","year":"1955","journal-title":"AMA Arch Otolaryngol"},{"issue":"02","key":"ref20","first-page":"107","article-title":"Antimicrobial therapy in ophthalmology","volume":"3","author":"D M Gordon","year":"1958","journal-title":"Surv Ophthalmol"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-5347(17)65974-3","article-title":"Interstitial cystitis","volume":"81","author":"W J Baker","year":"1959","journal-title":"J Urol"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0002-9610(55)90657-7","article-title":"The use of clorpactin WCS 90 as an antiseptic in surgery","volume":"90","author":"W A Swanker","year":"1955","journal-title":"Am J Surg"},{"issue":"05","key":"ref24","first-page":"S2","article-title":"Expert recommendations for the use of hypochlorous solution: science and clinical application","volume":"61","author":"D G Armstrong","year":"2015","journal-title":"Ostomy Wound Manage"},{"issue":"03","key":"ref25","first-page":"209","article-title":"Topical approaches to improve surgical outcomes and wound healing: a review of efficacy and safety","volume":"16","author":"K Totoraitis","year":"2017","journal-title":"J Drugs Dermatol"},{"issue":"12","key":"ref26","first-page":"342","article-title":"Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency","volume":"26","author":"S Sakarya","year":"2014","journal-title":"Wounds"},{"key":"ref27","first-page":"e5","article-title":"Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity","volume":"6","author":"L Wang","year":"2007","journal-title":"J Burns Wounds"},{"issue":"04","key":"ref29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/jb.19.4.295-302.1930","article-title":"Germicidal efficiency of chlorine and the N-chloro derivatives of ammonia, methylamine and glycine against anthrax spores","volume":"19","author":"F W Tilley","year":"1930","journal-title":"J Bacteriol"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/jb.30.2.163-171.1935","article-title":"Some observations on the germicidal efficiency of chloramine-T and calcium hypochlorite","volume":"30","author":"D B Charlton","year":"1935","journal-title":"J Bacteriol"},{"key":"ref31","volume-title":"Factors affecting the germicidal efficiency of hypochlorite solutions","author":"A S Rudolph","year":"1941"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/08927010802441412","article-title":"Neutral super-oxidised solutions are effective in killing P. aeruginosa biofilms","volume":"25","author":"K Sauer","year":"2009","journal-title":"Biofouling"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2474-14-222","article-title":"A systematic review of the evidence for single stage and two stage revision of infected knee replacement","volume":"14","author":"J PM Masters","year":"2013","journal-title":"BMC Musculoskelet Disord"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1051\/sicotj\/2016038","article-title":"The DAIR (debridement, antibiotics and implant retention) procedure for infected total knee replacement - a literature review","volume":"3","author":"S N Qasim","year":"2017","journal-title":"SICOT J"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s13018-019-1378-4","article-title":"Debridement, antibiotics, and implant retention for periprosthetic knee infections: a pooling analysis of 1266 cases","volume":"14","author":"G-X Qu","year":"2019","journal-title":"J Orthop Surg Res"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.arth.2019.09.011","article-title":"Dilute betadine lavage reduces the risk of acute postoperative periprosthetic joint infection in aseptic revision total knee and hip arthroplasty: a randomized controlled trial","volume":"35","author":"T E Calkins","year":"2020","journal-title":"J Arthroplasty"},{"issue":"13","key":"ref38","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2106\/JBJS.18.01285","article-title":"Use of povidone-iodine irrigation prior to wound closure in primary total hip and knee arthroplasty: an analysis of 11,738 cases","volume":"101","author":"N M Hernandez","year":"2019","journal-title":"J Bone Joint Surg Am"},{"issue":"13","key":"ref39","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2106\/JBJS.18.01152","article-title":"Povidone-iodine wound lavage to prevent infection after revision total hip and knee arthroplasty: an analysis of 2,884 cases","volume":"101","author":"A Hart","year":"2019","journal-title":"J Bone Joint Surg Am"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.artd.2017.03.005","article-title":"Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty","volume":"3","author":"N B Frisch","year":"2017","journal-title":"Arthroplast Today"},{"issue":"01","key":"ref41","first-page":"85","article-title":"Reduction in prosthetic joint infection after introduction of per-operative wound irrigation with chlorhexidine: a large scale evaluation of a chance in standard care","volume":"28","author":"M Rutgers","year":"2018","journal-title":"Hip Int"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1721087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T23:40:46Z","timestamp":1658187646000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1721087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":36,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,7,18]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1721087","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"value":"1538-8506","type":"print"},{"value":"1938-2480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,23]]}}}