{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:16:18Z","timestamp":1790266578557,"version":"4.1.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n            Objective\u2003Transient tachypnoea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD) during the newborn period. Chest radiography (CXR) is commonly used to rule out the diagnosis, but TTN is often misdiagnosed as neonatal respiratory distress syndrome (NRDS) on the basis of CXR alone. Increasing evidence suggests that lung ultrasound (LUS) may be a reliable diagnostic tool for transient tachypnoea of the newborn. However, studies of the diagnostic efficiency of LUS are still lacking. This study was aimed to evaluate the accuracy and reliability of LUS for diagnosing TTN by conducting a systematic review and meta-analysis.<\/jats:p><jats:p>\n            Study Design\u2003We searched for articles in the Embase, PubMed, and Cochrane Library databases from inception until May 31, 2020. The selected studies were diagnostic accuracy studies that reported the utility of LUS in the diagnosis of TTN. Two researchers independently extracted data and assessed quality using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Then, we created a bivariate model of mixed effects to calculate the sensitivity and specificity of LUS in diagnosing TTN. A summary receiver operator characteristic (SROC) curve was constructed to summarize the performance characteristics of LUS.<\/jats:p><jats:p>\n            Results\u2003Six studies involving 617 newborns were included in the review. LUS had a pooled sensitivity of 0.98 (confidence interval [CI]: 0.92\u20131.00) and a specificity of 0.99 (CI: 0.91\u20131.00). The area under the curve for LUS was 1.00 (0.98\u20131.0). Meta-regression revealed that LUS had a significant diagnostic accuracy for TTN.<\/jats:p><jats:p>\n            Conclusion\u2003The performance of ultrasound for the detection of TTN was excellent. Considering the various advantages of LUS compared with chest radiographs in diagnosing TTN, this study supports the routine use of LUS for the detection of TTN.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1721134","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T23:50:21Z","timestamp":1606434621000},"page":"0973-0979","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy and Reliability of Lung Ultrasound to Diagnose Transient Tachypnoea of the Newborn: Evidence from a Meta-analysis and Systematic Review"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-734X","authenticated-orcid":false,"given":"Hai-Ran","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Huizhou Municipal Central Hospital, Huizhou Guangdong, Republic of China"},{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Beijing Chaoyang District Maternal and Child Healthcare Hospital, Beijing and National Neonatal Lung Ultrasound Training Center, Beijing, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-840X","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Beijing Chaoyang District Maternal and Child Healthcare Hospital, Beijing and National Neonatal Lung Ultrasound Training Center, Beijing, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Kang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Neonatal Intensive Care Unit, Huizhou Municipal Central Hospital, Huizhou Guangdong, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"issue":"07","key":"ref1","first-page":"987","article-title":"Respiratory distress in the newborn","volume":"76","author":"C L Hermansen","year":"2007","journal-title":"Am Fam Physician"},{"issue":"145","key":"ref2","doi-asserted-by":"publisher","DOI":"10.3791\/58990","article-title":"Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus","volume":"76","author":"J Liu","year":"2019","journal-title":"J Vis Exp"},{"key":"ref3","volume-title":"Transient tachypnea of the newborn","author":"K Jha","year":"2020"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000493001","article-title":"Lung ultrasound for the differential diagnosis of respiratory distress in neonates","volume":"115","author":"I 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