{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:11:44Z","timestamp":1780528304137,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100008590","name":"Swedish Stroke Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008590","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Karolinska Institutet Coagulation Fund"},{"name":"Stockholm Regional Fund for Research, Development, and Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombin is increasingly recognized to be of importance for cardiovascular disease. The aim of this study was to investigate the prognostic value of thrombin generation variables in a cohort of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA). Thrombin generation potential measured by calibrated automated thrombogram (CAT) and prothrombin fragment F1\u2009+\u20092 was determined in the acute and convalescent phases for a cohort of 190 patients with AIS\/TIA. Microvesicle (MV)-induced thrombin generation potential was determined for a subset of patients using modified CAT. Primary outcome was a composite of fatal and nonfatal AIS or myocardial infarction as documented in Swedish registers during a total follow-up of 986 patient-years. Hazard ratios (HRs) were calculated using Cox regression based on variable median split. Peak thrombin and endogenous thrombin potential (ETP) above median in the acute phase were associated with a reduced risk of primary outcome after adjustment for cardiovascular risk factors, HR: 0.50 (0.27\u20130.92), p\u2009=\u20090.026 and HR: 0.53 (0.28\u20130.99), p\u2009=\u20090.048, respectively. F1\u2009+\u20092 was lower in patients than in healthy controls but not associated with outcome. MV-induced peak thrombin above median in the acute phase was associated with recurrent AIS, unadjusted HR: 2.65 (1.03\u20136.44), p\u2009=\u20090.044. Contrary to expectation, high thrombin generation potential is associated with a reduced risk of recurrent ischemic event in patients with AIS\/TIA. Low ETP\/peak thrombin combined with high MV-induced peak thrombin can potentially identify patients at high risk of recurrence.<\/jats:p>","DOI":"10.1055\/s-0040-1721146","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T23:32:03Z","timestamp":1607815923000},"page":"584-593","source":"Crossref","is-referenced-by-count":4,"title":["High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study"],"prefix":"10.1055","volume":"121","author":[{"given":"Annika","family":"Lundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"\u00c4ngg\u00e5rdh-Rooth","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Charlotte","family":"Laska","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Wall\u00e9n","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/cvr\/cvp066","article-title":"Is thrombin a key player in the \u2018coagulation-atherogenesis\u2019 maze?","volume":"82","author":"J I Borissoff","year":"2009","journal-title":"Cardiovasc 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