{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T06:06:05Z","timestamp":1745301965591,"version":"3.37.3"},"reference-count":25,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Castleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.<\/jats:p>","DOI":"10.1055\/s-0040-1721158","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T13:27:49Z","timestamp":1606224469000},"page":"225-229","source":"Crossref","is-referenced-by-count":4,"title":["Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report"],"prefix":"10.25259","volume":"12","author":[{"given":"Timothy Amos","family":"Ekwere","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Uyo\/University of Uyo Teaching Hospital, Uyo, Akwa Ibom, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-4976","authenticated-orcid":false,"given":"Uchechukwu Brian","family":"Eziagu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Uyo\/University of Uyo Teaching Hospital, Uyo, Akwa Ibom, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"issue":"16","key":"ref2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1182\/blood.2019000931","article-title":"Overview of Castleman disease","volume":"135","author":"A Dispenzieri","year":"2020","journal-title":"Blood"},{"issue":"01","key":"ref3","first-page":"26","article-title":"CASE records of the Massachusetts General Hospital weekly clinicopathological exercises: case 40011 Vol. 250","volume":"250","author":"B Castleman","year":"1954","journal-title":"N Engl J Med"},{"issue":"05","key":"ref4","first-page":"1","article-title":"Unicentric Castleman\u2019s disease: case report and literature review","volume":"9","author":"K M Garc\u00eda","year":"2018","journal-title":"Canc Ther Oncol Int J"},{"issue":"05","key":"ref5","first-page":"550","article-title":"Castleman disease. 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