{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:07Z","timestamp":1781179087572,"version":"3.54.1"},"reference-count":16,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":254,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Primary bone lymphoma (PBL) is a rare disease, representing &lt;5% of all extranodal non-Hodgkin\u2019s lymphomas (NHLs). The optimal treatment strategy is still unclear. Here, we report our institutional outcome analysis of patients diagnosed with PBL.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003From 2007 to 2014, the medical records of 22 patients with PBL were reviewed. Analysis was done for symptom-, patient-, disease-, and treatment-related characteristics. All patients were treated with chemotherapy with or without radiotherapy. Treatment response and impact of different prognostic factors on clinical outcome were analyzed.<\/jats:p>\n                  <jats:p>Results\u2003The median age of presentation was 44 years (range: 18\u201370 years). A total of 19 (86.4%) patients were \u226460 years of age and 3 (13.6%) patients were &gt;60 years. Out of all, 18 were males and 4 were females. Ann Arbor clinical staging at diagnosis was Stage I in 13 (59.1%), Stage II in 3 (13.6%), Stage III in 2 (9.1%), and Stage IV in 4 (18.2%) patients. Spine was the most common site of involvement seen in 12 (54.5%) patients. Diffuse large B cell lymphoma histology was seen in 8 (36.4%) patients and 8 (36.4%) had high-grade NHL. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone was given to 20 (90.9%) patients, whereas 2 (9.1%) patients received cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab. Radiotherapy (30-40 Gy) was delivered to 19 (86.4%) patients. The median follow-up period was 40 months (range: 8\u2013105 months). The overall response rate was 86.3% with complete response (CR) in 15 (68.1%) and partial response in 4 (18.2%) patients. Relapses were seen in three (13.5%) patients: two nodal, and one in the bone. Disease-free survival (DFS) and overall survival (OS) at 5 years were 56.6 and 72.7%, respectively. CR after initial treatment was associated with a significant better OS, 80 and 25%, respectively (p &lt; 0.0001). Age, sex, stage, International Prognostic Index, histologic subtype, and number of sites had no significant influence on OS. Combining radiation therapy with chemotherapy (with or without rituximab) also did not improve the OS or DFS of patients.<\/jats:p>\n                  <jats:p>Conclusion\u2003In spite of small number of patients reported in this study, conventional chemotherapy remains an effective treatment option for patients with PBL. OS was found to be affected by the initial response to treatment.<\/jats:p>","DOI":"10.1055\/s-0040-1721173","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T18:31:08Z","timestamp":1623522668000},"page":"227-229","source":"Crossref","is-referenced-by-count":0,"title":["Primary Bone Lymphoma: An Experience of a Regional Cancer Center from India"],"prefix":"10.25259","volume":"09","author":[{"given":"Rohit","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budhi Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Chander","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikhar","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0360-3016(97)00106-5","article-title":"Localized primary malignant lymphoma of bone","volume":"37","author":"P Dubey","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1182\/asheducation-2009.1.523","article-title":"The 2008 WHO classification of lymphomas: implications for clinical practice and translational research","volume":"1","author":"E S Jaffe","year":"2009","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"03","key":"ref3","first-page":"270","article-title":"Primary non-Hodgkin\u2019s lymphoma of bone","volume":"26","author":"J Baar","year":"1999","journal-title":"Semin Oncol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5045\/kjh.2012.47.3.213","article-title":"Clinical characteristics and outcomes of primary bone lymphoma in Korea","volume":"47","author":"S Y Kim","year":"2012","journal-title":"Korean J Hematol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/annonc\/mdl329","article-title":"A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency","volume":"18","author":"K M Ramadan","year":"2007","journal-title":"Ann Oncol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1200\/JCO.1999.17.4.1244","article-title":"Report of an international workshop to standardize response criteria for non-Hodgkin\u2019s lymphomas","volume":"17","author":"B D Cheson","year":"1999","journal-title":"J Clin Oncol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.clon.2012.02.006","article-title":"Primary bone lymphoma","volume":"24","author":"N G Mikhaeel","year":"2012","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/cncr.24828","article-title":"Primary lymphoma of bone in adult patients","volume":"116","author":"M U Jawad","year":"2010","journal-title":"Cancer"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000351051","article-title":"Primary bone lymphoma: a retrospective analysis of 22 patients treated in a single tertiary center","volume":"130","author":"A Matikas","year":"2013","journal-title":"Acta Haematol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/jjco\/hym007","article-title":"Primary bone lymphoma: a new and detailed characterization of 28 patients in a single-institution study","volume":"37","author":"D Maruyama","year":"2007","journal-title":"Jpn J Clin Oncol"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/1097-0142(19891201)64:11<2387::AID-CNCR2820641132>3.0.CO;2-1","article-title":"Malignant lymphomas of bone in Japan","volume":"64","author":"T Ueda","year":"1989","journal-title":"Cancer"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/sj.leu.2401582","article-title":"Primary non-Hodgkin\u2019s lymphoma of bone: a clinicopathological investigation of 60 cases","volume":"13","author":"F H Heyning","year":"1999","journal-title":"Leukemia"},{"issue":"03","key":"ref13","first-page":"280","article-title":"Primary bone lymphoma: experience with 52 patients","volume":"88","author":"P L Zinzani","year":"2003","journal-title":"Haematologica"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1002\/cncr.21930","article-title":"Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients","volume":"106","author":"K Beal","year":"2006","journal-title":"Cancer"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10428190903308007","article-title":"Primary bone lymphoma\u2013the University of Miami experience","volume":"51","author":"A Alencar","year":"2010","journal-title":"Leuk Lymphoma"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clml.2011.03.021","article-title":"Primary bone lymphoma: evaluation of chemoimmunotherapy as front-line treatment in 21 patients","volume":"11","author":"C Pellegrini","year":"2011","journal-title":"Clin Lymphoma Myeloma Leuk"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1721173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:18Z","timestamp":1781176338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/primary-bone-lymphoma-an-experience-of-a-regional-cancer-center-from-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":16,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,6,12]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1721173","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}