{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:58:05Z","timestamp":1767772685529,"version":"3.37.3"},"reference-count":22,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uterine leiomyoma is the most prevalent benign type of gynecological tumor. It affects more than 80% of women worldwide and, within this group, more than 50% may be asymptomatic. However, large fibroid volumes may be associated with symptoms of extrinsic compression, and most of the cases do not present atypical cells. We present the case of a 49-year-old woman who underwent a total abdominal hysterectomy of a 13.5-kg uterine leiomyoma with no malignancies at histopathology and review the literature about giant uterine leiomyomas and their clinical repercussion. We concluded that large volumes do not always pose a threat regarding malignancy; however, future molecular studies are needed to investigate giant uterine fibroids.<\/jats:p>","DOI":"10.1055\/s-0040-1721351","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:44:30Z","timestamp":1611963870000},"page":"066-071","source":"Crossref","is-referenced-by-count":4,"title":["Does Big Mean Evil? Giant, but Benign Uterine Leiomyoma: Case Report and Review of the Literature"],"prefix":"10.61622","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-4718","authenticated-orcid":false,"given":"Luiz Gustavo Oliveira","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade de Campinas, Campinas, SP, Brazil"},{"name":"Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-6407","authenticated-orcid":false,"given":"Natalia Lysei","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-494X","authenticated-orcid":false,"given":"Maira Rossmann","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"S 03","key":"ref1","doi-asserted-by":"publisher","first-page":"S185","DOI":"10.4103\/2141-9248.141955","article-title":"Pharmacological treatment of uterine fibroids","volume":"4","author":"R Moroni","year":"2014","journal-title":"Ann Med Health Sci Res"},{"key":"ref2","first-page":"2s","article-title":"Giant uterine tumors: case report and review of the literature","volume":"50","author":"H S Jonas","year":"1977","journal-title":"Obstet 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