{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:32Z","timestamp":1740126812532,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n            Objective\u2003It is not known how much surfactant must be nebulized to reach a lung dose of phospholipids equivalent to that obtained by the instillation of 200\u2009mg\/kg of surfactant. We aimed to assess the feasibility of nebulizing a high-dose of poractant alfa with the eFlow-Neos investigational vibrating-membrane nebulizer in newborn piglets on nasal continuous positive airway pressure (nCPAP) and to determine whether this intervention would yield therapeutic lung doses of phospholipids.<\/jats:p><jats:p>\n            Study Design\u2003Twelve 1-day-old piglets on nCPAP received 600\u2009mg\/kg of poractant alfa admixed with technetium-99m via nebulization. Six piglets receiving 200\u2009mg\/kg of instilled synthetic surfactant served as controls. Lung deposition (percentage of the nominal dose) was determined by gamma scintigraphy, and the phospholipids' lung dose was calculated.<\/jats:p><jats:p>\n            Results\u2003The lung dose of phospholipids (mean\u2009\u00b1\u2009standard deviation [SD]) was 138\u2009\u00b1\u200996\u2009mg\/kg with nebulization, and 172\u2009\u00b1\u200924\u2009mg\/kg with instillation (p\u2009=\u20090.42). Nebulization took 58\u2009\u00b1\u200912\u2009minutes. The arterial partial pressure of carbon dioxide increased from 6.7\u2009\u00b1\u20091.1 to 7.2\u2009\u00b1\u20091.1 kPa during nebulization (p\u2009=\u20090.04). Cerebral oximetry remained stable, and there was no hemodynamic instability.<\/jats:p><jats:p>\n            Conclusion\u2003Nebulization was well tolerated, and the mean lung dose of phospholipids was above 100\u2009mg\/kg, that is, not different from the instillation group. These experimental findings suggest that it may be feasible to reach therapeutic lung doses of phospholipids by surfactant nebulization during nCPAP.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1721392","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T23:50:21Z","timestamp":1606434621000},"page":"1001-1007","source":"Crossref","is-referenced-by-count":4,"title":["Nebulization of High-Dose Poractant Alfa in Newborn Piglets on Nasal Continuous Positive Airway Pressure Yields Therapeutic Lung Doses of Phospholipids"],"prefix":"10.1055","volume":"39","author":[{"given":"Anders","family":"Nord","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesia and Intensive Care, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Preclinical Pharmacology, R&D, Chiesi Farmaceutici S.p.A., Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Salomone","sequence":"additional","affiliation":[{"name":"Department of Preclinical Pharmacology, R&D, Chiesi Farmaceutici S.p.A., Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Preclinical Pharmacology, R&D, Chiesi Farmaceutici S.p.A., Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schlun","sequence":"additional","affiliation":[{"name":"PARI Pharma GmbH, Starnberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Linner","sequence":"additional","affiliation":[{"name":"Cardiothoracic Anesthesia and Intensive Care, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-5203","authenticated-orcid":false,"given":"Doris","family":"Cunha-Goncalves","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesia and Intensive Care, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, 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