{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:09:24Z","timestamp":1761664164335,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004919","name":"KACST","doi-asserted-by":"crossref","award":["408\u201334"],"award-info":[{"award-number":["408\u201334"]}],"id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"crossref"}]},{"name":"RAC KFSHRC","award":["2130036"],"award-info":[{"award-number":["2130036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction\u2003Inherited bleeding disorders vary in prevalence due to genetic disparity and ethnicity. Little is known about the prevalence of coagulation factor deficiency and bleeding disorders in middle-eastern population.<\/jats:p><jats:p>Methods\u2003Young Saudi adults with at least one positive bleeding symptom reported in semi-structured validated condensed MCMDM-1vWD questionnaire were tested for complete blood count, routine and special coagulation tests, serum ferritin level, and capillary zone electrophoresis. After initial testing, those with prolonged prothrombin time (PT) or activated prothrombin time (APTT) had further testing to evaluate coagulation factors level. Platelet function was tested through platelet function analyzer (PFA)-100, and multiplate aggregometer (MEA) on patients suspected of having platelet disorders.<\/jats:p><jats:p>Results\u2003Six-hundred-forty patients (male\u2009=\u2009347, 54.2%) were included. A possible platelet function defect was diagnosed in three patients with one matching Glanzmann's thrombasthenia trait pattern, and one that of Bernard-Soulier trait pattern. One patient was diagnosed with von Willebrand disease. Deficiencies in coagulation factor levels were revealed as F-VIII in 14 (7.4%), F-IX in 15 (7.6%), F-II in two (3.3%), F-V in 17 (26.1%), FVII in two (3.1%), and F-X in one (1.8%) of study subjects; low vWF activity (&lt;50%) was found in 14 (8%). Abnormal values were found for various laboratory tests with prolongation of platelet function analyzer-epinephrine (PFA-EPI) in 11%, PFA-ADP or arachidonic acid in 15.2%, PT in 35.9%, and APTT in 63.7%. Five-hundred-seventy-six patients (90%) had normal results in the coagulation factor assays and were categorized as patients with bleeding of unknown cause (BUC). A diagnosis of a bleeding disorder was more frequently made in men than in women (38 vs. 26). Iron deficiency anemia was found in 18 (25%) females positively associated with F-IX deficiency (p-value 0.000). Male gender (73.3%, p\u2009=\u20090.007) was independently associated with the diagnosis of coagulation factor deficiency.<\/jats:p><jats:p>Conclusion\u2003The current study reports a higher prevalence of coagulation factors deficiency in Saudi population than reported in the western population.<\/jats:p>","DOI":"10.1055\/s-0040-1721500","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:02:13Z","timestamp":1608768133000},"page":"e457-e462","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Coagulation Factors Deficiency among Young Adults in Saudi Arabia: A National Survey"],"prefix":"10.1055","volume":"04","author":[{"given":"Khalid A.","family":"AlSaleh","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-856X","authenticated-orcid":false,"given":"Nouf","family":"Al-Numair","sequence":"additional","affiliation":[{"name":"Department of Genetics, King Faisal Specialist Hospital and Research Centre, and College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"AlSuliman","sequence":"additional","affiliation":[{"name":"Research Center, King Faisal Specialist Hospital, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Zolaly","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Taibah University, Medina, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Majeed","family":"Albanyan","sequence":"additional","affiliation":[{"name":"College of Medical Applied Sciences, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf","family":"AlOtaishan","sequence":"additional","affiliation":[{"name":"Department of Genetics, King Faisal Specialist Hospital and Research Centre, and College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Abudouleh","sequence":"additional","affiliation":[{"name":"College of Medical Applied Sciences, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nervana","family":"Bayoumy","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Tarawah","sequence":"additional","affiliation":[{"name":"Medina Maternity and Children Hospital, Medina, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"AlZahrani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"AlAllaf","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Umm Al Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul kareem","family":"AlMomen","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raihan","family":"Sajid","sequence":"additional","affiliation":[{"name":"Department of Pathology, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-300X","authenticated-orcid":false,"given":"Tarek M.","family":"Owaidah","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-0029-1225757","article-title":"Introduction: rare bleeding disorders: general aspects of clinical features, diagnosis, and management","volume":"35","author":"F Peyvandi","year":"2009","journal-title":"Semin Thromb Hemostasis"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/jth.13368","article-title":"A diagnostic approach to mild bleeding 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