{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:30:12Z","timestamp":1762918212809,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n            Objective\u2003In this currently evolving coronavirus disease 2019 (COVID-19) pandemic, the evidence is scarce about the impact of COVID-19 infection on women in labor and neonates in an inner city African-Americans (AA) population. The objective of this study was to evaluate the clinical outcomes and placental pathology in mother\u2013infant dyads in COVID-19 cases.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective chart review was conducted on 34 COVID-19 positive mother\u2013infant dyads to study their baseline characteristics and outcomes. Placental pathology was reviewed by two perinatal pathologists.<\/jats:p><jats:p>\n            Results\u2003COVID-19 was noted in 3% of pregnant women who delivered in our institution. The majority (82%) of them were asymptomatic. Out of the four mothers who were symptomatic, only three (9%) required supplemental oxygen. None of them required invasive ventilation. All the neonates tested negative for COVID-19 at 24\u2009hours of age. There were no gross or microscopic pathological abnormalities detected that could be definitely associated with any COVID-19 related complications during pregnancy in any of the 34 placentas.<\/jats:p><jats:p>\n            Conclusion\u2003COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. Our study did not find any evidence of vertical transmission of COVID-19 infection nor any specific findings on placental pathology.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1721673","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:54:58Z","timestamp":1612238098000},"page":"e15-e20","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Characteristics of Mother\u2013Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population"],"prefix":"10.1055","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-7743","authenticated-orcid":false,"given":"Sanket","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Central Michigan University School of Medicine, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wayne State University School of Medicine, Hutzel Women's Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wayne State University School of Medicine, Hutzel Women's Hospital, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Central Michigan University School of Medicine, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujit","family":"Bajaj","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Velumula","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Agu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Central Michigan University School of Medicine, Children's Hospital of Michigan, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41591-020-0822-7","article-title":"Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China","volume":"26","author":"J T Wu","year":"2020","journal-title":"Nat Med"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1090198120929677","article-title":"Social vulnerability and racial inequality in COVID-19 deaths in Chicago","volume":"47","author":"S J Kim","year":"2020","journal-title":"Health Educ Behav"},{"issue":"19","key":"ref5","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1001\/jama.2020.6548","article-title":"COVID-19 and African Americans","volume":"323","author":"C W Yancy","year":"2020","journal-title":"JAMA"},{"issue":"13","key":"ref6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/jama.2020.2131","article-title":"Novel coronavirus infection in hospitalized infants under 1 year of age in China","volume":"323","author":"M Wei","year":"2020","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records","volume":"395","author":"H Chen","year":"2020","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fped.2020.00104","article-title":"Infants born to mothers with a new coronavirus (COVID-19)","volume":"8","author":"Y Chen","year":"2020","journal-title":"Front Pediatr"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/AOG.0000000000003985","article-title":"Testing of patients and support persons for coronavirus disease 2019 (COVID-19) infection before scheduled deliveries","volume":"136","author":"A Bianco","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/AOG.0000000000003979","article-title":"Clinical findings and disease severity in hospitalized pregnant women with coronavirus disease 2019 (COVID-19)","volume":"136","author":"V M Savasi","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"07","key":"ref11","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/aogs.13867","article-title":"Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies","volume":"99","author":"M Zaigham","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-0040-1710050","article-title":"Severe COVID-19 during pregnancy and possible vertical transmission","volume":"37","author":"M C Alzamora","year":"2020","journal-title":"Am J Perinatol"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/00313020600696280","article-title":"The placentas of patients with severe acute respiratory syndrome: a pathophysiological evaluation","volume":"38","author":"W F Ng","year":"2006","journal-title":"Pathology"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1093526620925569","article-title":"Placental pathology in COVID-19 positive mothers: preliminary findings","volume":"23","author":"R N Baergen","year":"2020","journal-title":"Pediatr Dev Pathol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/ajcp\/aqaa089","article-title":"Placental pathology in COVID-19","volume":"154","author":"E D Shanes","year":"2020","journal-title":"Am J Clin Pathol"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: amsterdam placental workshop group consensus statement","volume":"140","author":"T Y Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0046-8177(00)80241-5","article-title":"Chronic deciduitis in the placental basal plate: definition and interobserver reliability","volume":"31","author":"T Y Khong","year":"2000","journal-title":"Hum Pathol"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/modpathol.2010.73","article-title":"The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth","volume":"23","author":"C J Kim","year":"2010","journal-title":"Mod Pathol"},{"issue":"22","key":"ref21","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMc2009316","article-title":"Universal screening for SARS-CoV-2 in women admitted for delivery","volume":"382","author":"D Sutton","year":"2020","journal-title":"N Engl J Med"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ijgo.13182","article-title":"A systematic scoping review of COVID-19 during pregnancy and childbirth","volume":"150","author":"F Elshafeey","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"issue":"22","key":"ref23","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1001\/jama.2020.8259","article-title":"Interpreting diagnostic tests for SARS-CoV-2","volume":"323","author":"N Sethuraman","year":"2020","journal-title":"JAMA"},{"issue":"18","key":"ref24","first-page":"1846","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn","volume":"323","author":"L Dong","year":"2020","journal-title":"JAMA"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1055\/s-0040-1712161","article-title":"Vertical transmission of severe acute respiratory syndrome coronavirus 2: a systematic review","volume":"37","author":"Z Yang","year":"2020","journal-title":"Am J Perinatol"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ajog.2003.11.019","article-title":"Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome","volume":"191","author":"S F Wong","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.ajog.2015.08.041","article-title":"Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance","volume":"213","author":"C J Kim","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/jpm-2018-0055","article-title":"The frequency and type of placental histologic lesions in term pregnancies with normal outcome","volume":"46","author":"R Romero","year":"2018","journal-title":"J Perinat Med"},{"issue":"08","key":"ref29","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/hupa.2000.9036","article-title":"Villous capillary lesions of the placenta: distinctions between chorangioma, chorangiomatosis, and chorangiosis","volume":"31","author":"S Ogino","year":"2000","journal-title":"Hum Pathol"},{"issue":"06","key":"ref30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5858\/arpa.2015-0160-OA","article-title":"Chorangiosis of chorionic villi: what does it really mean?","volume":"140","author":"J Stanek","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"06","key":"ref31","doi-asserted-by":"crossref","first-page":"493.e1","DOI":"10.1016\/j.ajog.2012.03.025","article-title":"Clustering of maternal-fetal clinical conditions and outcomes and placental lesions","volume":"206","author":"J Stanek","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/plac.2002.0895","article-title":"Changes in fetal capillaries during preplacental hypoxia: growth, shape remodelling and villous capillarization in placentae from high-altitude pregnancies","volume":"24","author":"T M Mayhew","year":"2003","journal-title":"Placenta"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1721673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T03:55:09Z","timestamp":1612238109000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1721673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":28,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,1,13]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1721673","relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"type":"print","value":"2157-6998"},{"type":"electronic","value":"2157-7005"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}