{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:22:06Z","timestamp":1791386526974,"version":"4.3.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5K12HD001262-18"],"award-info":[{"award-number":["5K12HD001262-18"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n            Objective\u2003Monochorionic, diamniotic (MCDA) twin pairs are predisposed to various pregnancy complications due to the unique placental angioarchitecture of monochorionicity. Few studies have evaluated the outcomes of weight-discordant MCDA pairs without selective fetal growth restriction (SFGR) or the risk factors for development of SFGR. This study aims to describe the natural history of expectant, noninvasive management of weight-discordant MCDA twins and to evaluate risk factors associated with progression to SFGR.<\/jats:p><jats:p>\n            Study Design\u2003This was a retrospective cohort study at a single, tertiary care center in the United States. All MCDA twins with isolated intertwin weight discordance (ITWD)\u2009\u2265\u200920% diagnosed before 26 weeks' gestational age (GA) were included. The primary outcome of descriptive analyses was overall pregnancy outcome, incorporating both survival to delivery and GA at delivery, as defined by the North American Fetal Therapy Network. The secondary outcome was SFGR in one twin (defined as estimated fetal weight\u2009&lt;\u200910% for GA) and factors associated with this progression. Only those with fetal ultrasound (US) within 4 weeks of delivery were included in this secondary analysis.<\/jats:p><jats:p>\n            Results\u2003Among 73 MCDA pairs with ITWD, 73% had a good pregnancy outcome, with dual live delivery at a median GA of 33 weeks. Among the 34 pairs with adequate US follow-up, 56% developed SFGR. There were no differences in GA at delivery or discordance at birth between those who did and those who did not develop SFGR. There was a nonsignificant association between increasing ITWD at diagnosis and subsequent development of SFGR.<\/jats:p><jats:p>\n            Conclusion\u2003Expectant, noninvasive management can be considered in MCDA twin pregnancies with ITWD\u2009\u2265\u200920% diagnosed before 26 weeks. This approach is associated with a good pregnancy outcome in the majority of cases, even after the development of SFGR in the smaller twin.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1721697","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T23:44:10Z","timestamp":1608075850000},"page":"649-656","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of Monochorionic, Diamniotic Twin Pregnancies with Prenatally Diagnosed Intertwin Weight Discordance"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-3185","authenticated-orcid":false,"given":"Nasim C.","family":"Sobhani","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa N.","family":"Sparks","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Gosnell","sequence":"additional","affiliation":[{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Rand","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie A.","family":"Feldstein","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"},{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, 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Gynecol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/uog.18966","article-title":"Weight discordance and perinatal mortality in twin pregnancy: systematic review and meta-analysis","volume":"52","author":"F D'Antonio","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"F P Hadlock","year":"1991","journal-title":"Radiology"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1097\/AOG.0000000000001709","article-title":"Practice bulletin 169: multifetal gestations: twin, triplet, and higher-order multifetal pregnancies","volume":"128","author":"E J Hayes","year":"2016","journal-title":"Obstet Gynecol"},{"key":"ref10","first-page":"e1","article-title":"Management of monochorionic 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