{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:32Z","timestamp":1740126812467,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"DOI":"10.13039\/100013595","name":"AMAG Pharmaceuticals","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013595","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to evaluate the impact of 17-hydroxyprogesterone caproate (17-OHPC) on recurrent preterm birth (PTB) in women with a prior PTB and a current dichorionic\/diamniotic twin gestation.<\/jats:p><jats:p>\n            Study Design\u2003We combined individual patient-level data from two prospective randomized placebo-controlled trials of prophylactic 17-OHPC in twin gestation and compared the rates of recurrent spontaneous PTB in those women with a prior singleton PTB randomized to placebo or 17-OHPC (250\u2009mg weekly).<\/jats:p><jats:p>\n            Results\u2003Only 7.4% of women with dichorionic\/diamniotic twin gestation experienced a prior PTB. Among these 66 women, spontaneous delivery prior to 34 weeks occurred significantly less often (p\u2009=\u20090.03) in those randomized to 17-OHPC (20.6%) than in those randomized to placebo (46.9%). However, mean gestational length was not significantly different, and there was no statistically significant difference in composite neonatal outcome.<\/jats:p><jats:p>\n            Conclusion\u200317-OHPC may be beneficial to women with a prior PTB and a current dichorionic\/diamniotic twin gestation. These findings along with those reported by the Maternal Fetal Medicine Units Network in singletons suggest a common mechanism of action and a specific target population, those with a prior PTB, that may benefit from 17-OHPC treatment. A large prospective trial is needed to validate these findings.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1721713","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T23:44:10Z","timestamp":1608075850000},"page":"1183-1188","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent Preterm Birth Reduction by 17-Hydroxyprogesterone Caproate in Dichorionic\/Diamniotic Twin Gestation"],"prefix":"10.1055","volume":"39","author":[{"given":"Christina","family":"Megli","sequence":"additional","affiliation":[{"name":"School of Medicine, Departments of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Clinical Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Andrew","family":"Combs","sequence":"additional","affiliation":[{"name":"The Mednax Center for Research, Education, Quality, and Safety, Sunrise, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Venkataramanan","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Pathology and the School of Pharmacy Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Lemon","sequence":"additional","affiliation":[{"name":"School of Medicine, Departments of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"School of Medicine, Departments of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa035140","article-title":"Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate","volume":"348","author":"P J Meis","year":"2003","journal-title":"N Engl J Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"390.e1","DOI":"10.1016\/j.ajog.2012.09.013","article-title":"17 alpha-hydroxyprogesterone caproate to prevent prematurity in nulliparas with cervical length less than 30\u2009mm","volume":"207","author":"W A Grobman","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMoa070641","article-title":"A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in 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outcome in multiple pregnancies: a randomized controlled trial","volume":"118","author":"A C Lim","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/SMJ.0b013e3181afee12","article-title":"Progesterone does not prevent preterm births in women with twins","volume":"102","author":"C M Briery","year":"2009","journal-title":"South Med J"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"194.e1","DOI":"10.1016\/j.ajog.2013.01.032","article-title":"Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial","volume":"208","author":"M V Senat","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.ajog.2012.08.001","article-title":"Relationship between 17-hydroxyprogesterone caproate 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