{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:04:51Z","timestamp":1777961091893,"version":"3.51.4"},"reference-count":127,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tubal patency testing was initially introduced as a diagnostic test. However, it has been observed that some tubal patency tests also have a therapeutic effect. This therapeutic effect can be influenced by the contrast medium used during tubal flushing. In this review, we discuss current evidence associated with different methods for tubal flushing and their potential impact on reproductive outcomes in women with unexplained infertility. Furthermore, we discuss their diagnostic accuracy, safety, and cost-effectiveness.<\/jats:p>","DOI":"10.1055\/s-0040-1721720","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:12:29Z","timestamp":1608336749000},"page":"074-086","source":"Crossref","is-referenced-by-count":7,"title":["Tubal Flushing Treatment for Unexplained Infertility"],"prefix":"10.1055","volume":"38","author":[{"given":"Nienke van","family":"Welie","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Ludwin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland"},{"name":"Ludwin and Ludwin Gynecology, Private Medical Center, Krakow, Poland"},{"name":"Centermed, Private Hospital and Clinic, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wellington P.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil"},{"name":"Reproductive Medicine, SEMEAR fertilidade, Ribeirao Preto\/SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velja","family":"Mijatovic","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The 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Steiner","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref16","first-page":"293","article-title":"The therapeutic effects of oil-soluble hysterosalpingography contrast medium following water-soluble hysterosalpingography contrast medium","volume":"44","author":"K N Yang","year":"1989","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.fertnstert.2015.03.032","article-title":"Role of tubal surgery in the era of assisted reproductive technology: a committee opinion","volume":"103","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2015","journal-title":"Fertil Steril"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0015-0282(99)00382-9","article-title":"A randomized, prospective, controlled study of laparoscopic dye studies and selective salpingography as diagnostic tests of fallopian tube 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Maheux-Lacroix","year":"2014","journal-title":"Hum Reprod"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jmig.2017.04.007","article-title":"Three-dimensional hysterosalpingo contrast sonography with gel foam: methodology and feasibility to obtain 3-dimensional volumes of tubal shape","volume":"24","author":"C Exacoustos","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"issue":"02","key":"ref44","first-page":"123","article-title":"Ultrasonography reappraisal of tubal patency in assisted reproduction technology patients: comparison between 2D and 3D-sonohysterosalpingography. 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Study protocol for a randomized controlled trial","volume":"18","author":"J van Rijswijk","year":"2018","journal-title":"BMC Womens Health"},{"issue":"03","key":"ref52","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/j.fertnstert.2019.07.1332","article-title":"Can hysterosalpingo foam sonography (HyFoSy) replace hysterosalpingography (HSG) as first choice tubal patency test: a randomized comparison (foam study)?","volume":"112","author":"N van Welie","year":"2019","journal-title":"Fertil Steril"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"4827376","DOI":"10.1155\/2019\/4827376","article-title":"Clinical aspects of HyFoSy as tubal patency test in subfertility workup","volume":"2019","author":"N Exalto","year":"2019","journal-title":"BioMed Res Int"},{"issue":"02","key":"ref54","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/humupd\/dmu057","article-title":"Diagnostic accuracy of saline infusion sonography in the evaluation of uterine cavity abnormalities prior to assisted reproductive techniques: a systematic review and meta-analyses","volume":"21","author":"S Seshadri","year":"2015","journal-title":"Hum Reprod Update"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/uog.17352","article-title":"Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leiomyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta-analysis","volume":"50","author":"C A Bittencourt","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"12","key":"ref56","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.7863\/jum.2009.28.12.1671","article-title":"Diagnostic value of sonohysterography in the determination of fallopian tube patency as an initial step of routine infertility assessment","volume":"28","author":"M Hajishafiha","year":"2009","journal-title":"J Ultrasound 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study","volume":"20","author":"T P\u00e9rez-Medina","year":"2005","journal-title":"Hum Reprod"},{"issue":"08","key":"ref60","first-page":"CD009592","article-title":"Surgical intervention versus expectant management for endometrial polyps in subfertile women","author":"K Jayaprakasan","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/09513590600604673","article-title":"Effects of the position of fibroids on fertility","volume":"22","author":"M L Casini","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"ref62","first-page":"CD009461","article-title":"Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities","volume":"12","author":"J Bosteels","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref63","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/humrep\/dez284","article-title":"Septum resection in women with a septate uterus: a cohort study","volume":"35","author":"J FW Rikken","year":"2020","journal-title":"Hum Reprod"},{"issue":"01","key":"ref64","first-page":"CD008576","article-title":"Septum resection for women of reproductive age with a septate uterus","volume":"1","author":"J F Rikken","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12905-018-0637-6","article-title":"The randomised uterine septum transsection trial (TRUST): design and protocol","volume":"18","author":"J FW Rikken","year":"2018","journal-title":"BMC Womens Health"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/S0140-6736(16)00231-2","article-title":"Hysteroscopy before in-vitro fertilisation (inSIGHT): a multicentre, randomised controlled trial","volume":"387","author":"J G Smit","year":"2016","journal-title":"Lancet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/S0140-6736(16)00258-0","article-title":"Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial","volume":"387","author":"T El-Toukhy","year":"2016","journal-title":"Lancet"},{"issue":"04","key":"ref68","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/humrep\/den003","article-title":"A new rapid and effective method for treatment of unexplained infertility","volume":"23","author":"G Edelstam","year":"2008","journal-title":"Hum Reprod"},{"issue":"04","key":"ref69","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.rbmo.2010.01.003","article-title":"Prospective randomized study for hydrotubation versus no hydrotubation before intrauterine insemination in unexplained infertility","volume":"20","author":"M A Aboulghar","year":"2010","journal-title":"Reprod Biomed 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Swart","year":"1995","journal-title":"Fertil Steril"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmq056","article-title":"Are patient characteristics associated with the accuracy of hysterosalpingography in diagnosing tubal pathology? 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review","volume":"17","author":"E van den Boogaard","year":"2011","journal-title":"Hum Reprod Update"},{"issue":"07","key":"ref92","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/jama.2019.10931","article-title":"Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis","volume":"322","author":"T IM Korevaar","year":"2019","journal-title":"JAMA"},{"issue":"06","key":"ref93","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0022-3476(83)80028-6","article-title":"Iodine-induced alterations of thyroid function in newborn infants after prenatal and perinatal exposure to povidone iodine","volume":"102","author":"D l'Allemand","year":"1983","journal-title":"J Pediatr"},{"issue":"05","key":"ref94","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/humrep\/deaa049","article-title":"Thyroid function in neonates conceived after hysterosalpingography with iodinated contrast","volume":"35","author":"N van Welie","year":"2020","journal-title":"Hum Reprod"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0627","article-title":"Iodine contrast prior to or during pregnancy and neonatal thyroid function: a systematic review","author":"N van Welie","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"06","key":"ref96","first-page":"OD05","article-title":"A rare case of delayed pulmonary oedema due to methemoglobinemia following laparoscopic chromopertubation with methylene blue","volume":"8","author":"C M Veerendrakumar","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejogrb.2019.03.019","article-title":"Allergy-like reactions to methylene blue following laparoscopic chromopertubation: a systematic review of the literature","volume":"238","author":"M Akazawa","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod 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to (serial) hysterosalpingography. 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